Publications


[ 1-99 ] [ 100-199 ] [ 200-299 ] [ 300-399 ] [ 400-499 ] [ 500- ] [ in press ]

499. Johnson, K., Zhu, S., Tremblay, M., Payette, J.N., Wang, J., Bouchez, L.C., Meeusen, S., Althage, A., Cho, C., Wu, X., Schultz, P.G. "A stem cell-based approach to cartilage repair." Science, 336(6082):717-2, 2012.
498. Kazane, S.A., Sok, D., Uson, M.L., Cho, E.H., Kuhn, P., Schultz, P.G., Smider, V.V. "Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR." Proc. Nat. Acad. Sci., 109(10):3731-6, 2012.
497. Dubrovska A., Elliott J., Salamone R.J., Telegeev G.D., Stakhovsky A.E., Schepotin I.B., Yan F., Wang Y., Bouchez L.C., Kularatne S.A., Watson J., Trussell C., Reddy V.A., Cho C.Y., Schultz P.G. "CXCR4 expression in prostate cancer progenitor cells." PLoS One, 2012;7(2):e31226, 2012.
496. Tianero, M.D.B., Donia, M.S., Young, T.S., Schultz, P.G., Schmidt, E.W. "Ribosomal route to small molecule diversity." J. Am. Chem. Soc., 134(1):418-25, 2012.
495. Meister, S., Plouffe, D.M., Kuhen, K., Bonamy, G.M.C., Barnes, S.W., Bopp, S.E., Borboa, R., Bright, A.T., Che, J., Cohen, S., Garging, K., Gettayacamin, M., Groessl, T., Kato, N., Lee, M.C.S., McNamara, C., Nagle, A., Nam, T.G., Roland, J., Rottman, M., Zhou, B., Fidock, D.A., Froissard, P., Glynne, R.J., Mazier, D., Sattabongkot, J., Schultz, P.G., Tuntland, T ., Walker, J.R., Zhou, Y., Diagana, T.T., Chatterjee, A., Winzeler, E.A. "Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery." Science, 334(6061):1372-7, 2011.
494. Nam, Tae-gyu, McNamara C., Bopp, S., Dharia, N., Meister, S., Plouffe, D.M., Kato, N., McCormack, S., Bursulaya, B., Ke, H., Vaidya, A.B., Schultz, P.G., Winzeler, E.A. "A chemical genomic analysis of decoquinate, a P. falciparum cytochrome B inhibit." ACS Chem. Biol., 6(11):1214-22, 2011.
493. Charbon, G., Wang, J., Brustad. E., Schultz, P.G., Horwich, A.L., Jacobs-Wagner, C., Chapman, E. "Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid." Bioorg. Med. Chem. Lett., 15:21(20)6067-70, 2011.
492. Liu, J., Johnson, K., Li, J., Piamonte, V., Steffy, B.M., Hsieh, M., Ng, N., Zhang, J., Walker, J.R., Ding, S., Muneoka, K., Wu, X., Glynne, R., Schultz, P.G. "A Regenerative Phenotype in Mice with a Point Mutation in TGFBR1." Proc. Nat. Acad. Sci., 108(35):14560-5, 2011.
491. Young, D.D., Jockush, S., Turro, N.J., Schultz, P.G. "Synthetase polyspecificity as a tool to modulate protein function." Bioorg. Med. Chem. Lett., 21(24):7502-4, 2011.
490. Gonzalez, R., Lee, J.W., Schultz, P.G. "Step-Wise Chemically-Induced Cardiomyocyte Specification of Human Embryonic Stem Cells." Angew. Chem., 50(47):11181-5, 2011.
489. Shoji, S., Dambacher, C.M., Shajani, Z., Williamson, J.R., Schultz, P.G. "Systematic chromosomal deletion and characterization of essential ribosomal proteins." J. Mol. Biol., 413(4):751-61, 2011.
488. Minnihan, E., Young, D.D., Schultz, P.G., Stubbe, J. "Incorporation of fluorotyrosines into ribonucleotide reductases using an evolved, polyspecific aminoacyl-tRNA synthetase." J. Am. Chem. Soc., 133(40):15942-5, 2011.
487. Dubrovska, A., Kim, C., Elliott, J., Shen, W. Tun-Hsun Kuo, T., Koo, S-H., Li, C., Tuntland, T., Chang, J., Groessl, T., Wu, X., Ramirez-Montagut, T., Spiegel, D.A., Cho, C.Y., Schultz, P.G. "A Chemically Induced Vaccine Strategy for Prostate Cancer." ACS Chem. Biol., 6(11):1223-1231, 2011.
486. Lee, J.W., Hirota, T., Peters, E.C., Garcia, M., Gonzalez, R., Cho, C.Y., Schultz, P.G., Kay, S.A. "A small molecule modulates circadian rhythms through PER protein phosphorylation." Angew. Chem., epub, 2011.
485. Thielges, M.C., Axup, J.Y., Wong, D., Lee, H., Chung, J.K., Schultz, P.G., Fayer, M.D. "2D IR Spectroscopy of Protein Dynamics Using Two Vibrational Labels - a Site-Specific Genetically Encoded Unnatural Amino Acid and an Active Site Ligand." J. Phys. Chem. B., 115(38):11294-11304, 2011.
484. Gauba, V., Grunewald, J., Gorney, V., Deaton, L., Kang, M., Bursulaya, B., Ou, W., Lerner, R.A., Schmedt, C., Geierstanger, B.H., Schultz, P.G., Ramirez-Montagut, T. "Loss of CD4 T-cell dependent tolerance to proteins with modified amino acids." Proc. Nat. Acad. Sci., 108(31):12821-6, 2011.
483. Hanndeouche, S., Zhang, J., Yi, T., Shen, W., Nguyen, D., Pereira, J.P., Guerini, D., Baumgarten, B. U., Roggo, S., Wen, B., Knochenmuss, R., Noel, S., Gessier, F., Kelly, L.M., Vanek, M., Laurent, S., Preuss, I., Miault, C., Christen, I., Karuna, R., Li, W., Koo, D., Suply, T., Schmedt, C., Peters, E.C., Flachetto, R., Katopkis, A., Spanka, C., Roy, M.O., Detheux, M., Chen, Y.A., Schultz, P.G., Cho, C.Y., Seuwen, K., Cyster, J.G., Sailer, W.A. "Oxysterols direct immune cell migration through EBI1." Nature, 475(7357):524-7, 2011.
482. Berezhna, S.Y., Supekova, L., Sever, M.J., Schultz, P.G., Deniz, A.A. "Dual Regulation of Hepatitis C Viral RNA by Cellular RNAi Requires Partitioning of Ago2 to Lipid Droplets and P-bodies." PLoS ONE, epub, 2011.
481. Young, T.S., Young. D.D., Ahmad, I., Louis, J.M., Benkovic, S.J., Schultz, P.G. "The Evolution of Cyclic Peptide Protease Inhibitors." Proc. Nat. Acad. Sci., 108(27):11052-11056, 2011.
480. Ai, H., Shen, W., Sagi, A., Chen, P.R., Schultz, P.G. "Probing protein-protein interactions with a genetically encoded photocrosslinking amino acid." ChemBioChem, epub, 2011.
479. Cho, H.S., Daniel, T., Buechler, Y.J., Litzinger, D.C., Maio, Z., Putnam, A-M. H., Kraynov, V., Sim, B-C., Bussell, S., Javahishvilli, T., Kaphle, S., Viramontes, G., Ong, M., Chu, S., GC, B., Lieu, R., Knudsen, N., Castiglioni, P., Norman, T., Axelrod, D.W., Hoffman, A.R., Schultz, P.G., DiMarchi, R., Kimmel, B.E. "Optimized clinical performance of growth hormone with an expanded genetic code." Proc. Nat. Acad. Sci, 108(22):9060-5, 2011.
478. Staerk, J., Lyssiotis, C.A., Medeiro, L.A., Bollong, M., Foreman, R.K., Zhu, S., Garcia, M., Gao, Q., Bouchez, L.C., Lairson, L.L., Charette, B.D., Supekova, L., Janes, J., Brinker, A., Cho, C.Y., Jaenisch, R., Schultz, P.G. "Pan-Src Family Kinase Inhibitors Replace Sox2 During the Direct Reprogramming of Somatic Cells." Angew Chem, 50(25):5734-6, 2011.
477. Tao, H., Jin, Q., Koo, D-I., Liao, X., Englund, N.P., Wang, Y., Ramamurthy, A., Schultz, P.G., Dorsch, M., Kelleher, J., Wu, X. "Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug Resistant Mutant of Smoothened." Chem. Biol., 18(4):432-7, 2011.
476. Nam, T.G., Lee, J., Walker, J.R., Brinker, A., Cho, C.Y., Schultz, P.G. "Identification and Characterization of Small Molecule Inducers of Fetal Hemoglobin." ChemMedChem, 6(5):777-80, 2011.
475. Bouchez, L.C., Boitano, A.E., de Lichtervelde, L., Romeo, R., Cooke, M.P., Schultz, P.G. "Small Molecule Regulators of Human Stem Cell Self-Renewal." ChemBioChem, 12(6):854-7, 2011.
474. Young, D.D., Young, T.S., Jahnz, M., Ahmad, I., Spraggon, G., Schultz, P.G. "An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity" Biochem., 50(11):1894-900, 2011.
473. Gonzalez, R., Lee, J.W., Schultz, P.G. "Dorsomorphin Promotes Human Embryonic Stem Self-Renewal." Angew. Chem. Int. Ed. Engl., 50(15):3439-41, 2011.
472. Hutchins, B.M., Kazane, S.A., Staflin, K., Forsyth, J.S., Felding-Habermann, B., Smider, V.V., Schultz, P.G. "Selective Formation of Covalent Protein Heterodimers with a Nonnatural Amino Acid." Chem Biol., 18(3):299-30, 2011.
471. Hutchins, B.M., Kazane, S.A., Staflin, K., Forsyth, J., Felding-Habermann, B., Schultz, P.G., Smider, V.V. "Site-specific coupling and sterically controlled formation of multimeric antibody Fab fragments using unnatural amino acids." J. Mol. Biol., 406(4):595-603, 2011.
470. Lyssiotis, C.A., Lairson, L.L., Boitano, A.E., Wurdak, H., Zhu, S., Schultz, P.G. "Chemical Control of Stem Cell Fate and Developmental Potential." Angew. Chem., 50(1):200-42, 2011.
469. Hirota, T., Lee, J.W., Lewis, W.G., Zhang, E.E., Breton, G., Liu, X., Garcia, M., Peters, E.C., Etchegaray, J-P., Traver, D., Schultz, P.G., Kay, S.A. "High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase." PLoS Biol., 8(12):e1000559, 2010.
468. Dubrovska, A., Elliott, J., Salamone, R.J., Aimone, L.J., Walker, J.R., Kim, S., Watson, J., Cho, C.Y., Reddy, V.A., Schultz, P.G. "Combinatorial therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma." Clin. Cancer Res., 16(23):5692-702, 2010.
467. Groff, D., Wang, F., Jockusch, S., Turro, N.J., Schultz, P.G. "A New Strategy to Photoactivate GFP." Angew. Chem., 49(42):7677-9, 2010.
466. Wurdak, H., Zhu, S., Min, K.H., Aimone, L., Lairson, L.L., Watson, J., Chopiuk, G., Demas, J., Charette, B., Halder, R., Weerapana, E., Cravatt, B.F., Cline, H.T., Peters, E.C., Zhang, J., Walker, J.R., Wu, C., Chang, J., Tuntland, T., Cho, C.Y., Schultz, P.G. "A small molecule accelerates neuronal differentiation in the adult rat." Proc. Nat. Acad. Sci., 107(38):16542-7, 2010.
465. Hu, X.V., Lyssiotis, C.A., Tao, H., Baker, R.K., Rodrigues, T.M.A., Miraglia, L., Orth, A.P., Lyons, G.E., Schultz, P.G., Wu, X. "Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen." Proc. Nat. Acad. Sci., 107(34):15087-92, 2010.
464. Boitano, A.E., Wang, J., Romeo, R., Bouchez, L.C., Parker, A., Sutton, S., Walker, J.R., Tellew, J., Denision, M., Cooke, M.P., Schultz, P.G. "Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells." Science, 329(5997):1345-8, 2010.
463. Zhu, S., Wurdak, H., Schultz, P.G. "Directed Embryonic Stem Cell Differentiation with Small Molecules." Future Med Chem., 2(6):965-973, 2010.
462. Teo, H., Ghosh, S., Leusch, H., Ghosh, A., Wong, E.T., Malik, N., Orth, A., de Jesus, P., Perry, A.S., Oliver, J.D., Tran, N.L., Speiser, L.J., Wong, M., Saez, E., Schultz, P.G., Chanda, S.K., Verma, I.M., Tergaonkar, V. "Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression." Nat. Cell Biol., 12(8):758-67, 2010.
461. Ai, H., Lee, J.W., Schultz, P.G. "A method to site-specifically introduce methyllysine into proteins in E. coli." Chem. Commun., 46(30):5506-8, 2010.
460. Hur, W., Sun, Z., Mason, D.E., Luesch, H., Peters, E.C., Zhang, D.D., Schultz, P.G., Gray, N.S. "A Small Molecule Inducer of the Antioxidant Response Element." Chem. Biol., 17:537-547, 2010.
459. Groff, D., Chen, P.R., Schultz, P.G. "A Genetically Encoded ε-N-methyl Lysine in Mammalian Cells." ChemBioChem, 11(8):1066-8, 2010.
458. Liu, C.C., Schultz, P.G. "Adding new chemistries to the genetic code." Ann. Rev Biochem, 79:413-44, 2010.
457. Supekova, L., Supek, F., Greer, J.E., Schultz, P.G. "A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression." Proc. Nat. Acad. Sci., 107(11):5047-52, 2010.
456. Wang, F., Robbins, S., Guo, J., Shen, W., Schultz, P.G. "Genetic Incorporation of Unnatural Amino Acid into Proteins in Mycobacterium tuberculosis." PLoS ONE, 5(2):e9354, 2010.
455. Young, T.S., Schultz P.G. "Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon." J. Biol. Chem., 285(15):11039-44, 2010.
454. Gonzalez, R., Jennings, L., Knuth, M., Orth, A., Klock, H., Ou, W., Feuerhelm, J., Hull, M., Koesema, E., Wang, Y., Zhang, J., Wu, C., Cho, C.Y., Su, A.I., Batalov, S., Chen, H., Johnson, K., Laffitte, B., Nguyen, D., Schultz, P.G., Harris, J.L., Lesley, S.A. "Screening the Mammalian Extracellular Proteome for Regulators of Human Embryonic Stem Cell Pluripotency." Proc. Nat. Acad. Sci., 107(8):3552-7, 2010.
453. Ai, H., Shen, W., Brustad, E.M., Schultz, P.G. "Genetically Encoded Alkenes in Yeast." Angew. Chem., 49(5):935-7, 2010.
452. Young, T.S., Ahmad, I., Yin, J.A., Schultz, P.G. "An enhanced system for unnatural amino acid incorporation in E. coli." J. Mol. Biol., 395(2):361-374, 2010.
451. Wurdak, H., Romero, A., Zhu, S., Lorger, M., Watson, J., Chiang, C., Zhang, J., Natu, V.S., Tu, B.P., Walker, J., Harsh, G.R., Felding-Habermann, B., Orth, A.P., Miraglia, L.J., Rines, D.R., Skirboll, S.L., Schultz, P.G. "An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation." Cell Stem Cell, 6(1):37-47, 2010.
450. Liu, C.C., Cellitti, S., Geierstanger, B., Schultz, P.G. "Efficient expression of tyrosine-sulfated proteins in E. coli using an expanded genetic code." Nat. Protoc., 4(12):1784-9, 2009.
449. Fleissner, M.R., Brustad, E.M., Kálai, T., Altenbach, C., Cascio, D., Peters, F.B., Hideg, K., Schultz, P.G., Hubbell, W.L. "Site-directed Spin Labeling of a genetically Encoded Unnatural Amino Acid." Proc. Nat. Acad. Sci., 106(51):21637-42, 2009.
448. Liu, C.C., Choe, H., Farzan, M., Smider, V.V., Schultz, P.G. "Mutagenesis and Evolution of Sulfated Antibodies using an Expanded Genetic Code." Biochemistry, 48(37):8891-8, 2009.
447. Guo, J., Melançon III, C.E., Lee, H.S., Groff, D., Schultz, P.G. "Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids." Angew. Chem., 48(48):9148-51, 2009.
446. Lemke, E.A., Gambin, Y., Vandelinder, V., Brustard, E.M., Liu, H-W., Schultz, P.G., Groisman, A., Deniz, A.A. "Microfluidic Device for Single-Molecule Fluorescence Experiments with Enhanced Photostability." J. Am. Chem. Soc., 131(38):13610-2, 2009.
445. Jones, C.A., Nishiya, N., London, N.R., Zhu, W., Sorensen, L.K., Chan, A., Lim, C.J., Chen, H., Zhang, Q., Schultz, P.G., Hayallah, A.M., Thomas, K.R., Famulok, M., Zhang, K., Ginsberg, M.H., Li, D.Y. "Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity." Nat. Cell Biol., 11(11):1325-31, 2009.
444. Jones, D.H., Cellitti, S.E., Hao, X., Zhang, Q., Jahnz, M., Summerer, D., Schultz, P.G., Uno, T., Geierstanger, B.H. "Site-specific labeling of proteins with NMR-active unnatural amino acids." J. Biomol. NMR, 46(1):89-100, 2009.
443. Zhu, S., Wurdak, H., Wang, Y., Galkin, A., Tao, H., Li, J., Lyssiotis, C.A., Yan, F., Tu, B.P., Miraglia, L.A., Walker, J., Sun, F., Orth, A.P., Harris, J., Schultz, P.G., Wu, X. "A genomic screen identifies TYRO3 as a MITF regulator." Proc. Nat. Acad. Sci., 106(40):17025-30, 2009.
442. Mills, J., Lee, H.S., Liu, C.C., Wang, J., Schultz, P.G. "A Genetically Encoded, Direct Sensor of Antibody-Antigen Interactions." ChemBioChem, 10(13):2162-4, 2009.
441. Lee, H.S., Dimla, R.D., Schultz, P.G. "Protein-DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acid." Bioorg. Med. Chem. Let., 19(17):5222-4, 2009.
440. Lee, H.S., Guo, J., Lemke, E., Dimla, R., Schultz, P.G. "The Genetic Incorporation of a Small, Environmentally Sensitive, Fluorescent Probe into Proteins in Saccharomyces Cerevisiae." J. Am. Chem. Soc., 131(36):12921-3, 2009.
439. Wu, X., Schultz, P.G. "Synthesis at the Interface of Chemistry and Biology." J. Am. Chem. Soc., 131(35):12497-515, 2009.
438. Liu, C.C., Mack, A.V., Brustad, E.M., Mills, J.H., Groff, D., Smider, V.V., Schultz, P.G. "The Evolution of Proteins with Genetically Encoded 'Chemical Warheads.'" J. Am. Chem. Soc., 131(28):9616-7, 2009.
437. Lyssiotis, C.A. Foreman, R.K., Staerk, J., Garcia, M., Mathur, D., Meyerrose, S. Markoulaki, D.E., Hanna, J., Lairson, L.L., Charette, B.D., Bouchez, L.C., Bollong, M., Kunick, C., Brinker, A., Cho, C., Schultz, P.G., Jaenisch, R. "Reprogramming of murine fibroblasts to iPS cells with chemical complementation of Klf4." Proc. Nat. Acad. Sci., 106(22):8912-7, 2009.
436. Zhu, S., Wurdak, H., Wang, J., Lyssiotis, C.A., Peters, E.C., Cho, C., Wu, X., Schultz, P.G. "A small molecule primes embryonic stem cells for differentiation." CellStemCell, 4:416-426, 2009.
435. Chen, P.R., Groff, D., Guo, J., Ou, W., Geierstanger, B., Schultz, P.G. "A Facile System for Encoding Unnatural Amino Acids in Mammalian Cells." Angew. Chem., 48(22):4052-4055, 2009.
434. Melancon, C.E., Schultz, P.G. "One Plasmid Selection System for the Rapid Evolution of Aminoacyl-tRNA Synthetases." Bioorg. Med. Chem. Lett., 19(14):3845-7, 2009.
433. Groff, D., Thielges, M.C., Cellitti, S., Schultz, P.G., Romesberg, F.E. "Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase." Angew. Chem., 48(19):3478-81, 2009.
432. Young, T.S., Ahmad, I., Brock, A., Schultz, P.G. "Expanding the Genetic Repertoire of the Methylotrophic Yeast, Pichia pastoris." Biochemistry, 48(12):2643-2653, 2009.
431. Peters, F.B., Brock, A., Wang, J., Schultz, P.G. "Photocleavage of the Protein Backbone by Genetically Encoded 2-Nitrophenylalanine." Chem. Biol., 16(2):148-52, 2009.
430. Grünewald, J., Hunt, G.S., Dong, L., Niessen, F., Wen, B.G., Tsao, M-L., Perera, R., Kang, M., Laffitte, B.A., Azarian, S., Ruf, W., Nasoff, M., Lerner, R.A., Schultz, P.G., Smider, V.V. "Mechanistic Studies of the Immunochemical Termination of Tolerance with Unnatural Amino Acids." Proc. Nat. Acad.Sci., 106(11):4337-42, 2009.
429. Wikoff, W.R., Anfora, A.T., Liu, J., Schultz, P.G., Lesley, S.A., Peters, E.C., Siuzdak, G. "Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites." Proc. Nat. Acad. Sci., 106(10):3698-3703, 2009.
428. Lee, H.S., Spraggon, G., Schultz, P.G., Wang, F. "Genetic Incorporation of a Metal-ion Chelating Amino Acid into Proteins as a Biophysical Probe." J. Am. Chem. Soc., 131(7):2481-2483, 2009.
427. Wang, W., Walker, J.R., Wang, X., Tremblay, M.S., Lee, J.W., Wu, X., Schultz, P.G. "Small molecule inducers of pancreatic β-cell expansion." Proc. Nat. Acad. Sci., 106(5):1427-32, 2009.
426. Hirota,T., Lewis, W.G., Liu, A.C., Lee, J.W., Schultz, P.G., Kay, S.A. "A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β." Proc. Nat. Acad. Sci., 105(52):20746-51, 2008.
425. Brustad, E.M., Lemke, E., Schultz, P.G., Deniz, A.A. "A General and Efficient Method for the Site-Specific Dual Labeling of Proteins for Single Molecule FRET." J. Am. Chem. Soc., 130(52):17664-5, 2008.
424. Dubrovska, A., Kim, S., Salamone, R.J., Walker, J., Maira, S-M., García-Echeverría, C., Schultz, P.G., Reddy, V.A. "The role of PTEN/Akt/PI3K signaling on the maintenance and viability of prostate cancer stem-like cell populations." Proc. Nat. Acad. Sci., 106(1):268-273, 2009.
423. Liu, C.C., Mack, A.V., Tsao, M-L., Mills, J.H., Lee, H., Choe, H., Farzan, M., Schultz, P.G., Smider, V.V. "Protein Evolution with an Expanded Genetic Code." Proc. Natl. Acad. Sci., 105(46):17688-93, 2008.
422. Brustad, E., Bushey, M.L., Lee, J.W., Groff, D., Liu, W., Schultz, P.G. "A Genetically Encoded Boronate Amino Acid." Angew. Chem., 47(43):8220-3, 2008.
421. Brustad, E., Bushey, M.L., Brock, A., Chittuluru, J., Schultz, P.G. "A Promiscuous Aminoacyl-tRNA Synthetase that Incorporates Cysteine, Methionine, and Alanine Homologues into Proteins." Bioorg. Med. Chem. Let., 18(22):6004-6, 2008.
420. Lee, H., Schultz, P.G. "Biosynthesis of Site-specific DNA Cleaving Proteins." J. Am. Chem. Soc., 130(40):13194-5, 2008.
419. Grünewald, J., Tsao, M.-L., Perera, R., Dong, L., Niessen, F., Kubitz, D.M., Smider, V.V., Ruf, W., Nasoff, M., Lerner, R.A., Schultz, P.G. "Immunochemical Termination of Self-Tolerance." Proc. Natl. Acad. Sci., 105(32):11276-80, 2008.
418. Guo, J., Wang, J., Lee, J.-S., Schultz, P.G. "Site-Specific Incorporation of Methyl- and Acetyl-Lysine Analogues into Recombinant Proteins." Angew. Chem., 47(34):6399-401, 2008.
417. Plouffe, D., Brinker, A., McNamara, C., Henson, K., Kato, N., Kuhen, K., Nagle, A., Adrián, F., Matzen, J.T., Anderson, P., Nam, T.G., Gray, N.S., Chatterjee, A., Janes, J., Yan, S.F., Trager, R., Caldwell, J.S., Schultz, P.G., Zhou, Y., Winzeler, E.A. "In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen." Proc. Natl. Acad. Sci., 105(26):9059-64, 2008.
416. Cellitti, S.E., Jones, D.H., Lagpacan, L., Hao, X., Zhang, Q., Hu, H., Brittain, S.M., Brinker, A., Caldwell, J., Brock, A., Ryu, Y., Uno, T., Schultz, P.G., Geierstanger, B.H. "In vivo incorporation of unnatural amino acids to probe structure, dynamics and ligand binding in a large protein by Nuclear Magnetic Resonance spectroscopy." J. Am. Chem. Soc., 130(29):9268-81, 2008.
415. Kato, N., Sakata, T., Breton, G., Le Roch, K.G., Nagle, A., Andersen, C., Bursulaya, B., Henson, K., Johnson, J., Kumar, K.A., Marr, F., Mason, D.,McNamara, C., Plouffe, D., Ramachandran, V., Spooner, M., Tuntland, T., Zhou, Y., Peters, E.C., Chatterjee, A., Schultz, P.G., Ward, G.E., Gray, N., Harper, J., Winzeler, E.A. "Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility." Nat. Chem. Biol., 4(6): 347-356, 2008.
414. Lee, J., Hong, J., Nam, T.-G., Peters, E.C., Orth, A.P., Geierstanger, B.H., Goldfinger, L.E., Ginsberg, M.H., Cho, C.Y., Schultz, P.G. "A Small Molecule Inhibitor of α4 Integrin-Dependent Cell Migration." Bioorg. Med. Chem., 17(3):977-980, 2007.
413. Debler, E.W., Kaufmann, G.F., Meijler, M.M., Heine, A., Mee, J.M., Mukhopadhyay, S., Pljevaljcic, G., Di Bilio, A.J., Deniz, A.A., Schultz, P.G., Millar, D.P., Janda, K.D., Wilson, I.A., Gray, H.B., Lerner, R.A. "Deeply Inverted Electron-Hole Recombination Triggers Intensely Blue Luminescence in an Antibody-Stilbene Complex." Science, 319(5867):1232-5, 2008.
412. Graziano, J.J., Liu, W., Perera, R., Geierstanger, B.H., Lesley, S.A., Schultz, P.G. "Selecting folded proteins from a library of secondary structural elements." J. Am. Chem. Soc., 130(1):176-85, 2008, .
411. Guo, J., Wang, J., Anderson, J.C., Schultz, P.G. "Addition of an Alpha Hydroxy Acid to the Genetic Code of Bacteria." Angew. Chem., 47(4):722-725, 2007.
410. Tippmann, E.M., Liu, W., Summerer, D., Geierstanger, B., Mack, A.V., Schultz P.G. "A Genetically Encoded Diazirine Photocrosslinker in Escherichia coli." ChemBioChem, 8(18):2210-2214, 2007.
409. Seyedsayamdost, M.R., Xie, J., Chan, C.T., Schultz, P.G., Stubbe, J. "Site-specific Insertion of 3-Aminotyrosine into Subunit α2 of E. coli Ribonucleotide Reductase: Direct Evidence for Involvement of Y730 and Y731 in Radical Propagation." J. Am. Chem. Soc., 129(48):15060-15071, 2007.
408. Lemke, E.A., Summerer, D., Geierstanger, B.H., Brittain, S.M., Schultz, P.G. "Control of protein phosphorylation with a genetically encoded photocaged amino acid." Nat. Chem. Biol., 3(12):769-772, 2007.
407. Supekova, L., Supek, F., Lee, J., Chen, S., Gray, N., Pezacki, J., Schlapbach, A., Schultz, P.G., "Identification of human kinases involved in HCV replication by siRNA library screening." J. Biol. Chem., 283(1):29-36, 2008.
406. Xie, J., Liu, W., Schultz, P.G. "A Genetically Encoded Bidentate, Metal-binding Amino Acid." Angew. Chem., 46(48):9239-9242, 2007.
405. Lee, J., Wu, X., Pasca di Magliano, M., Peters, E.C., Wang, Y., Hong, J., Hebrok, M., Ding, S., Cho, C.Y., Schultz, P.G. "A Small Molecule Antagonist of the Hedgehog Signaling Pathway." ChemBioChem., 8(16):1916-1919, 2007.
404. Lyssiotis, C.A., Walker, J.R., Wu, C., Kondo, T., Schultz, P.G., Wu, X. "Inhibition of Histone Deacetylase Activity Induces Developmental Plasticity in Oligodendrocyte Precursor Cells." Proc. Natl. Acad. Sci., 104(38):14982-7, 2007.
403. Liu, C.C., Brustad, E., Liu, W., Schultz, P.G. "Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin." J. Amer. Chem. Soc., 129(35):10648-9, 2007.
402. Matsuda, S., Fillo, J.D., Henry, A.A., Rai, P., Wilkens, S.J., Dwyer, T.J., Geierstanger, B.H., Wemmer, D.E., Schultz, P.G., Spraggon, G., Romesberg, F.E. "Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs." J. Amer. Chem. Soc., 129(34):10466-10473, 2007.
401. Wang, J., Schiller, S., Schultz, P.G. "A Biosynthetic Route to Dehydroalanine Containing Proteins." Angew. Chem., 46(36):6849-6851, 2007.
400. Trisler, K., Looger, L.L., Sharma, V., Baker, M., Benson, D.E., Trauger, S., Schultz, P.G., Smider, V.V. "A Metalloantibody That Irreversibly Binds a Protein Antigen." J. Biol. Chem., 282(36):26344-53, 2007.