Publications


[ 1-99 ] [ 100-199 ] [ 200-299 ] [ 300-399 ] [ 400-499 ] [ 500- ] [ in press ]

199. Cho, C.Y., Liu, C.W., Wemmer, D.E., Schultz, P.G. "Cyclic and Linear Oligocarbamate Ligands for Human Thrombin." Bioorganic & Medicinal Chemistry, 7:1171-1179, 1999.
198. Liu, Y., Barrett, J.E., Schultz, P.G., Santi, D.V. "Tyrosine 146 of Thymidylate Synthase Assists Proton Abstraction from the 5-Position of 2'-Deoxyuridine 5'-Monophosphate." Biochemistry, 38:848-852, 1999.
197. Rosania, G.R., Merlie, J.Jr, Gray, N., Chang, Y.T., Schultz, P.G., Heald, R. "A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: Biochemical identification using Xenopus egg extracts." Proc. Natl. Acad. Sci. (USA), 96:4797-4802, 1999.
196. Loweth, C.J., Caldwell, W.B., Peng, X., Alivisatos, A.P., Schultz, P.G. "DNA-Based Assembly of Gold Nanocrystals." Angew. Chem. Int. Engl. Ed., 38(12):1808-1812, 1999.
195. I. Takeuchi, H. Chang, C. Gao, P.G. Schultz, X.-D. Xiang, R.P. Sharma, M.J. Downes, T. Venkatesan "Combinatorial Synthesis and Evaluation of Epitaxial Ferroelectric Device Libraries." Applied Physics Letters, 73(31):894, 1998.
194. Isaacs, E.D., Marcus, M.A., Aeppli, G., Xiang, X.-D., Sun, X., Schultz, P.G., Kao, M., Cargill, G.S. III, Haushalter, R. "Synchrotron X-ray Microbeam Diagnostics of Combinatorial Synthesis." Applied Physics Letters, 73:1820-1822, 1998.
193. Romesberg, F.E., Santarsiero, B.D., Spiller, B., Yin J., Barnes, D., Schultz, P.G., Stevens, R.S. "Structural and Kinetic Evidence for Strain in Biological Catalysis." Biochemistry, 37(41):14404-14409, 1998.
192. Pollitt, S.K., Schultz, P.G. "A Photochemical Switch for Controlling Protein-Protein Interactions." Angew. Chem. Int. Engl. Ed., 37(15):2104-2107, 1998.
191. Pedersen, H., Hölder, S., Sutherlin, D.P., Schwitter, U., King, D.S., Schultz, P.G. "A Method for Directed Evolution and Functional Cloning of Enzymes." Proc. Natl. Acad. Sci. (USA), 95:10523-10528, 1998.
190. Gray, N.S. Wodicka, L., Thunnissen, A.M. W.H., Norman, T.C., Kwon, S., Hernan Espinoza, F., Morgan, D.O., Barnes, G., LeClerc, S., Meijer, L., Kim, S.H., Lockhart, D. J., Schultz, P.G. "Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors." Science, 281:533-538, 1998.
189. Thorson, J.S., Cornish, V.W., Barrett, J.E., Cload, S.T., Yano,T., Schultz, P.G. "A Biosynthetic Approach for the Incorporation of Unnatural Amino Acids into Proteins." Methods in Molecular Biology, 77:43-73, 1998, .
188. Cho, C.Y., Youngquist, R.S., Paikoff, S.J., Beresini, M.H., Hebert, A.R., Berleau, L.T., Liu, C.W., Wemmer, D.E., Keough, T., Schultz, P.G. "Synthesis and Screening of Linear and Cyclic Oligocarbamate Libraries. Discovery of High Affinity Ligands for GP11b/IIIa." J. Am. Chem. Soc., 120(31):7706-7718, 1998.
187. Driggers, E.M., Liu, C.W., Wemmer, D.E., Schultz, P.G. "Structure of the Michaelis Complex of an Efficient Antibody Acyl Transferase Determined by Transferred Nuclear Overhauser Enhancement Spectroscopy." J. Am. Chem. Soc., 120(29):7395-7396, 1998.
186. Ting, A.Y., Shin, I., Lucero, C., Schultz, P.G. "Energetic Analysis of an Engineered Cation-π Interaction in Staphylococcal Nuclease." J. Am. Chem. Soc., 120(28):7135-7136, 1998.
185. Romesberg, F.E., Flanagan, M.E., Uno, T., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction." J. Am. Chem. Soc., 120(21):5160-5167, 1998.
184. Ma, L., Hsieh-Wilson, L.C., Schultz, P.G. "Antibody Catalysis of Peptidyl-prolyl cis-trans Isomerization in the Folding of RNase T1." Proc. Natl. Acad. Sci. (USA), 95:7251-7256, 1998.
183. Chang, H., Gao, C., Takeuchi, I., Yoo, Y., Wang, J., Schultz, P.G., Xiang, X.D., Sharma, R.P., Downes, M., Venkatesan, T. "Combinatorial Synthesis and High Throughput Evaluation of Ferroelectric/Dielectric Thin-Film Libraries for Microwave Applications." Appl. Phys. Lett., 72(17):2185-2187, 1998.
182. Driggers, E.M., Cho, H.S., Liu, C.W., Katzka, C.P., Braisted, A.C., Ulrich, H.D., Wemmer, D.E., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Pericyclic Rearrangement." J. Am. Chem. Soc., 120(9):1945-1958, 1998.
181. Romesberg, F.E., Spiller, B., Schultz, P.G., Stevens, R.C. "Immunological Origins of Binding and Catalysis in a Diels-Alderase Antibody." Science, 279:1929-1933, 1998.
180. Schultz, P.G., Xiang, X.D. "Combinatorial Approaches to Materials Science." Curr. Opin. Solid State and Mat. Sci., 3:153-158, 1998.
179. Wang, J., Yoo, Y., Gao, C., Takeuchi, I., Sun, X., Chang, H., Xiang, X.-D., Schultz, P.G. "Identification of a Blue Photoluminescent Composite Material from a Combinatorial Library." Science, 279:1712-1714, 1998.
178. Blackwood, M.E., Jr., Rush, T.S. III, Romesberg, F., Schultz, P.G., Spiro, T.G. "Alternative Modes of Substrate Distortion in Enzyme and Antibody Catalyzed Ferrochelation Reactions." Biochemistry, 37(3):779-782, 1998.
177. Thorson, J.S., Shin, I., Chapman, E., Stenberg, G., Mannervik, B., Schultz, P.G. "Analysis of the Role of the Active Site Tyrosine in Human Glutathione Transferase A1-1 by Unnatural Amino Acid Mutagenesis." J. Am. Chem. Soc., 120(2):451-452, 1998.
176. Barrett, J.E., Maltby, D.A., Santi, D.V., Schultz, P.G. "Trapping of the C5 Methylene Intermediate in Thymidylate Synthase." J. Am. Chem. Soc., 120(2):449-450, 1998.
175. Yu, J., Choi, S.Y., Moon, K-D., Chung, H-H., Youn, H.J., Jeong, S., Park, H., Schultz, P.G. "A Glycosidase Antibody Elicited Against a Chair-like Transition State Analog Using in vitro Immunization." Proc. Nat. Acad. Sci. (USA), 95:2880-2884, 1998.
174. Ulrich, H.D., Moore, F.L., Schultz, P.G. "Germline diversity within the mouse Igk-V9 gene family." Immunogenetics" 47:91-95, 1997, .
173. Ulrich, H.D., Schultz, P.G. "Analysis of Hapten Binding and Catalytic Determinants in a Family of Catalytic Antibodies." J. Mol. Biol., 275:95-111, 1998.
172. Shin, I., Ting, A.Y., Schultz, P.G. "Analysis of Backbone Hydrogen Bonding in a β-turn of Staphylococcal Nuclease." J. Am. Chem. Soc., 119(51):12667-12668, 1997.
171. Sun, X.-D., Wang, K-A., Yoo, Y., Wallace-Freedman, W.G., Gao, C., Xiang, X-D., Schultz, P.G. "Solution-Phase Synthesis of Luminescent Materials Libraries." Adv. Materials, 9(13):1046-1049, 1997.
170. Hall, D.G., Schultz, P.G. "Synthesis of Diverse Ethoxyformacetal Oligomers. Toward Libraries of Metal-Coordinating Unnatural Biopolymers." Tetrahedron Lett., 38(45):7825-7828, 1997.
169. Yu, J., Choi, S.Y., Lee, S., Yoon, H.J., Jeong, S., Mun, H., Park, H., Schultz, P.G. "Antibody-Catalyzed Glycosyl Transfer Reactions From In Vitro Immunization." Chem. Commun., 20:1957-1958, 1997.
168. Liu, D.R., Magliery, T.J., Schultz, P.G. "Characterization of an ‘Orthogonal’ Suppressor tRNA Derived from E. coli tRNA2Gln." Chem. & Biology, 4:685-691, 1997.
167. Xiang, X.-D., Schultz, P.G. "The Combinatorial Synthesis and Evaluation of Functional Materials." Physica C, 282:428-430, 1997.
166. Koh, J.T., Cornish, V.W., Schultz, P.G. "An Experimental Approach to Evaluating the Role of Backbone Interactions in Proteins Using Unnatural Amino Acid Mutagenesis." Biochemistry, 36(38):11314-11322, 1997.
165. Ulrich, H.D., Mundorff, E., Santarsiero, B.D., Driggers, E.M., Stevens, R.C., Schultz, P.G. "The Interplay Between Binding Energy and Catalysis in the Evolution of a Catalytic Antibody." Nature, 389:271-275, 1997.
164. Liu, D.R., Magliery, T.J., Pastrnak, M., Schultz, P.G. "Engineering a tRNA and Aminoacyl-tRNA Synthetase for the Site-Specific Incorporation of Unnatural Amino Acids into Proteins in Vivo." Proc. Nat. Acad. Sci.(USA)" 94:10092-10097, 1997, .
163. Park, Y., Luo, J., Schultz, P.G., Kirsch, J.F. "Noncoded Amino Acid Replacement Probes of the Aspartate Aminotransferase Mechanism." Biochemistry, 36(34):10517-10525, 1997.
162. Lu, Y., Wei, T., Duewer, F., Lu, Y., Ming, N.B., Schultz, P.G., Xiang, X.D. "Nondestructive Imaging of Dielectric-Constant Profiles and Ferroelectric Domains with a Scanning-Tip Microwave Near-field Microscope." Science, 276:2004-2006, 1997.
161. Chapman, E., Thorson, J.S., Schultz, P.G. "Mutational Analysis of Backbone Hydrogen Bonds in Staphylococcal Nuclease." J. Am. Chem. Soc., 119(30):7151-7152, 1997.
160. Sun, X.D., Gao, C., Wang, J., Xiang, X.-D., Schultz, P.G. "Identification and Optimization of Advanced Phosphors Using Combinatorial Libraries." Appl. Phys. Lett." 70:1-4, 1997, .
159. Wedemayer, G.J., Patten, P.A., Wang, L.H., Schultz, P.G., Stevens, R.C. "Structural Insights into the Evolution of an Antibody Combining Site." Science, 276:1665-1669, 1997.
158. Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C. "Crystal Structures of the Free and Liganded Form of an Esterolytic Catalytic Antibody." J. Mol. Biol., 268:390-400, 1997, .
157. Gray, N.S., Kwon, S., Schultz, P.G. "Combinatorial Synthesis of 2,9-Substituted Purines." Tet. Lett., 38(7):1161-1164, 1997.
156. Johnsson, K., Froland, W.A., Schultz, P.G. "Overexpression, Purification and Characterization of the Catalase-Peroxidase KatG from Mycobacterium tuberculosis." J. Biol. Chem., 272(5):2834-2840, 1997.
155. Peng, X., Wilson, T.E., Alivisatos, A.P., Schultz, P.G. "Synthesis and Isolation of a Homodimer of Cadmium Selenide Nanocrystals." Angew. Chem. Int. Engl. Ed., 36(112):145-147, 1997.
154. Kanamori, T., Nishikawa, S.-I., Shin, I., Schultz, P.G., Endo, T. "Probing the Environment Along the Protein Import Pathways in Yeast Mitochondria by Site-Specific Photocrosslinking." Proc. Natl. Acad. Sci. (USA), 94:485-490, 1997.
153. Cload, S.T., Liu, D.R., Froland, W.A., Schultz, P.G. "Development of Improved tRNAs for In Vitro Biosynthesis of Proteins Containing Unnatural Amino Acids." Chem. & Biology, 3:1033-1038, 1996.
152. Stevens, R.C., Hsieh-Wilson, L.C., Santarsiero, B.D., Wedemayer, G.J., Spiller, B., Wang, L.H., Barnes, D., Ulrich, H.D., Patten, P.A., Romesberg, F.E., Schultz, P.G. "Structural Studies of Catalytic Antibodies." Israel J. of Chem., 36:121-132, 1996.
151. Yoon, S.S., Oei, Y., Sweet, E., Schultz, P.G. "An Antibody-Catalyzed [2,3]-Elimination Reaction." J. Am. Chem. Soc., 118(46):11686-11687, 1996.
150. Driggers, E.M., Schultz, P.G. "Catalytic Antibodies." Adv. Protein Chem, 49:261-287, 1996.
149. Bi, Y., Schultz, P.G. "Building Blocks for Peptide and Carbamate Libraries." Bioorg. Med. Chem. Lett., 6(19):2299-2300, 1996.
148. Paikoff, S.J., Wilson, T.E., Cho, C.Y., Schultz, P.G. "The Solid Phase Synthesis of N-Alkylcarbamate Oligomers." Tet. Lett., 37(32):5653-5656, 1996.
147. Kim, J.M., Wilson, T.E., Norman, T.C., Schultz, P.G. "Synthesis of a Cyclic Urea as a Nonnatural Biopolymer Scaffold." Tet. Lett., 37(30):5309-5312, 1996.
146. Kim, J.M., Bi, Y., Paikoff, S.J., Schultz, P.G. "The Solid Phase Synthesis of Oligoureas." Tet. Lett., 37(30):5305-5308, 1996.
145. Prudent, J.R., Schultz, P.G. "RNA Catalysis and Transition State Stabilization." Nucleic Acids and Mol. Biology; (Edt., F. Eckstein and D.M.J. Lilley: Berlin), 10:383-395, 1996.
144. Alivisatos, A.P., Johnsson, K.P., Peng, X., Wilson, T.E., Loweth, C.J., Bruchez, Jr. M.P., Schultz, P.G. "Organization of ‘Nanocrystal Molecules’ Using DNA." Nature, 382:609-611, 1996.
143. Cornish, V.W., Hahn, K.M., Schultz, P.G. "Site-Specific Protein Modification Using a Ketone Handle." J. Am. Chem. Soc., 118(34):8150-8151, 1996.
142. Wei, T., Xiang, X.-D., Wallace-Freedman, W.G., Schultz, P.G. "Scanning Tip Microwave Near Field Microscope." Appl. Phys. Lett., 68(24):3506-3508, 1996.
141. Norman, T.C., Gray, N.S., Koh, J.T., Schultz, P.G. "A Structure-Based Library Approach to Kinase Inhibitors." J. Am. Chem. Soc., 118(29):7430-7431, 1996.
140. Conn, M.M., Prudent, J.R., Schultz, P.G. "Porphyrin Metalation Catalyzed by a Small RNA Molecule." J. Am. Chem. Soc., 118(25):7012-7013, 1996.
139. Flanagan, M.E., Jacobsen, J.R., Sweet, E., Schultz, P.G. "Antibody-Catalyzed Retro-Aldol Reaction." J. Am. Chem. Soc., 118(23):6078-6079, 1996.
138. Fan, E., Oei, Y., Sweet, E., Uno, T., Schultz, P.G. "Antibodies with Thiol-s-Transferase Activity." J. Am. Chem. Soc., 118:5474-5475, 1996.
137. Hsieh-Wilson, L.C., Schultz, P.G., Stevens, R.C. "Insights into Antibody Catalysis: Structure of an Oxygenation Catalyst at 1.9-Å Resolution." Proc. Natl. Acad. Sci. (USA), 93:5363-5367, 1996.
136. Ulrich, H.D., Driggers, E.M.G., Schultz, P.G. "Antibody Catalysis of Pericyclic Reactions." Acta Chemica Scandinavica, 50:328-332, 1996.
135. Uno, T., Ku, J., Prudent, J.R., Huang, A., Schultz, P.G. "An Antibody-Catalyzed Isomerizaton Reaction." J. Am. Chem. Soc., 118(16):3811-3817, 1996.
134. Sera, T., Schultz, P.G. "In Vivo Selection of Basic Region-Leucine Zipper Proteins with Altered DNA Binding Specificities." Proc. Natl. Acad. Sci. (USA), 93:2920-2925, 1996.
133. Hsieh-Wilson, L.C., Xiang, X.-D., Schultz, P.G. "Lessons from the Immune System: From Catalysis to Materials Science." Accts. Chem. Res., 29(3):164-170, 1996.
132. Liu, D.R., Cload, S.T., Pastor, R.M., Schultz, P.G. "Analysis of Active Site Residues in Escherichia coli Chorismate Mutase by Site-Directed Mutagenesis." J. Am. Chem. Soc., 118(7):1789-1790, 1996.
131. Cload, S.T., Liu, D.R., Pastor, R.M., Schultz, P.G. "Mutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilis." J. Am. Chem. Soc., 118(7):1787-1788, 1996.
130. Patten, P.A., Gray, N.S., Yang, P.L., Marks, C.B., Wedemayer, G.J., Boniface, J.J., Stevens, R.G., Schultz, P.G. "The Immunological Evolution of Catalysis." Science, 271:1086-1091, 1996.
129. Ulrich, H.D., Patten, P.A., Yang, P.L., Romesberg, F.E., Schultz, P.G. "Expression Studies of Catalytic Antibodies." Proc. Natl. Acad. Sci. (USA), 92:11907-11911, 1995.
128. Jacobsen, J.R., Schultz, P.G. "The Scope of Antibody Catalysis." Curr. Opin. Struc. Bio., 5:818-824, 1995.
127. Cook, S.N., Jack, W.E., Xiong, X., Danley, L.E., Ellman, J.A., Schultz, P.G., Noren, C.J. "Photochemically Initiated Protein Splicing." Angew. Chem. Int. Engl. Ed., 34(15):1629-1630, 1995.
126. Briceño, G., Chang, H., Sun, X., Schultz, P.G., Xiang, X.D. "A Class of Cobalt Oxide Magnetoresistance Materials Discovered With Combinatorial Synthesis." Science, 270:273-275, 1995.
125. Prudent, J.R., Staunton, J., Schultz, P.G. "Probing the Structural Determinants of a Catalytic RNA with Isomerase Activity" J. Am. Chem. Soc." 117:10145-10146, 1995, .
124. Schultz, P.G., Lerner, R.A. "From Molecular Diversity to Catalysis: Lessons from the Immune System." Science, 269:1835-1842, 1995.
123. Thorson, J.S., Chapman, E., Schultz, P.G. "Analysis of Hydrogen Bonding Strengths in Proteins Using Unnatural Amino Acids." J. Am. Chem. Soc., 117:9361-9362, 1995.
122. Ku, J., Schultz, P.G. "Alternate Protein Frameworks for Molecular Recognition." Proc. Natl. Acad. Sci. (USA), 92:6552-6556, 1995.
121. Xiang, X.-D., Sun, X., Briceño, G., Lou, Y., Wang, K.-A., Chang, H., Wallace-Freedman, W.G., Chen, S.-W., Schultz, P.G. "A Combinatorial Approach to Materials Discovery." Science, 268:1738-1740, 1995.
120. Jacobsen, J.R., Cochran, A.G., Stephans, J.C., King, D.S., Schultz, P.G. "Mechanistic Studies of Antibody-Catalyzed Pyrmidine Dimer Photocleavage." J. Am. Chem. Soc., 117:5453-5461, 1995.
119. Mendel, D., Cornish, V.W., Schultz, P.G. "Site-Directed Mutagenesis with an Expanded Genetic Code." Annu. Rev. Biophys. Biomol. Struct., 24:435-62, 1995.
118. Nowak, M.W., Kearney, P.C., Sampson, J.R., Saks, M.E., Labarca, C.G., Silverman, S.K., Zhong, W., Thorson, J., Abelson, J.N., Davidson, N., Schultz, P.G., Dougherty, D.A., Lester, H.A. "Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells." Science, 268:439-442, 1995.
117. Johnsson, K., King, D.S., Schultz, P.G. "Studies on the Mechanism of Action of Isoniazid and Ethionamide in the Chemotherapy of Tuberculosis." J. Am. Chem. Soc., 117:5009-5010, 1995.
116. Moran, E.J., Wilson, T.E., Cho, C.Y., Cherry, S.R., Schultz, P.G. "Novel Biopolymers for Drug Discovery." Biopolymers, 37:213-219, 1995.
115. Müller, W.T., Klein, D.L., Lee, T., Clarke, J., McEuen, P.L., Schultz, P.G. "A Strategy for the Chemical Synthesis of Nanostructures." Science, 268:272-273, 1995.
114. Cornish, V.W., Mendel, D., Schultz, P.G. "Probing Protein Structure and Function with an Expanded Genetic Code." Angew. Chem. Int. Engl. Ed., 34:621-633, 1995.
113. Thorson, J.S., Chapman, E., Murphy, E.C., Schultz, P.G. "Linear Free Energy Analysis of Hydrogen Bonding in Proteins." J. Am. Chem. Soc., 117:1157-1158, 1995.
112. Ku, J., Schultz, P.G. "Phage Display of Catalytically Active Staphlococcal Nuclease." Bioorg & Med. Chem., 2(12):1413-1415, 1994.
111. Cornish, V.W., Kaplan, M.I., Veenstra, D.L., Kollman, P.A., Schultz, P.G. "Stabilizing and Destabilizing Effects of Placing α-Branched Amino Acids in Protein a-Helices." Biochemistry, 33:12022-12031, 1994.
110. Cornish, V.W., Schultz, P.G. "A New Tool for Studying Protein Structure and Function." Current Opinion in Structural Biology, 4:601-607, 1994.
109. Johnsson, K., Schultz, P.G. "Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis." J. Am. Chem. Soc., 116:7425-7426, 1994.
108. Jacobsen, J.R., Schultz, P.G. "Antibody Catalysis of Peptide Bond Formation." Proc. Natl. Acad. Sci. (USA), 91:5888-5892, 1994.
107. Prudent, J.R., Uno, T., Schultz, P.G. "Expanding the Scope of RNA Catalysis." Science, 264:1924-1927, 1994.
106. Van Vranken, D.L., Panomitros, D., Schultz, P.G. "Catalysis of Carbamate Hydrolysis by an Antibody." Tetrahedron Letters, 35:3873-3876, 1994.
105. Huang, L., Sera, T., Schultz, P.G. "A Permutational Approach Toward Protein-DNA Recognition." Proc. Natl. Acad. Sci. (USA), 91:3969-3973, 1994.
104. Cornish, V.W., Benson, D.R., Altenbach, C.A., Hideg, K., Hubbell, W.L., Schultz, P.G. "Site Specific Incorporation of Biophysical Probes into Proteins." Proc. Natl. Acad. Sci. (USA), 91:2910-2914, 1994.
103. Shokat, K.M., Uno, T., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction." J. Am. Chem. Soc, 116:2261-2270, 1994.
102. Yu, J., Hsieh, L.C., Kochersperger, L., Yonkovich, S., Stephans, J.C., Gallop, M.A. Schultz, P.G. "Progress Toward An Antibody Glycosidase." Angew. Chem. Int. Engl. Ed., 33(3):339-341, 1994.
101. Braisted, A.C., Schultz, P.G. "An Antibody-Catalyzed Oxy Cope Rearrangement." J. Am. Chem. Soc., 116:2211-2212, 1994.
100. Hsieh, L.C., Stephans, J.C., Schultz, P.G. "An Efficient Antibody-Catalyzed Oxygenation Reaction." J. Am. Chem. Soc., 116:2167-2168, 1994.