Publications


[ 1-99 ] [ 100-199 ] [ 200-299 ] [ 300-399 ] [ 400-499 ] [ 500- ] [ in press ]

99. Campbell, D.A., Gong, B., Kochersperger, L.M., Yonkovich, S., Gallop, M.A., Schultz, P.G. "Antibody-Catalyzed Prodrug Activation." J. Am. Chem. Soc., 116:2165-2166, 1994.
98. Chung, H., Schultz, P.G. "Probing Ras Function with Unnatural Amino Acids." Chemistry & Biology, 1:vi-vii, 1994.
97. Uno, T., Gong, B., Schultz, P.G. "Stereoselective Antibody-Catalyzed Oxime Formation." J. Am. Chem. Soc., 116:1145-1146, 1994.
96. Pei, D., Schultz, P.G. "Artificial Nucleases." Nucleases, Cold Spring Harbor Laboratory, 317-340, 1993.
95. Angeles, T.S., Smith, R.G., Darsley, M.J., Sugasawara, R., Sanchez, R.I., Kenten, J., Schultz, P.G., Martin, M.T. "Isoabzymes: Structurally and Mechanistically Similar Catalytic Antibodies from the Same Immunization." Biochemistry, 32:12128-12135, 1993.
94. Chung, H.H., Benson, D.R., Cornish, V.W., Schultz, P.G. "Probing the Role of Loop 2 in Ras Function with Unnatural Amino Acids." Proc. Natl. Acad. Sci. (USA), 90:10145-10149, 1993.
93. Judice, J.K., Gamble, T.R., Murphy, E.C., de Vos, A.M., Schultz, P.G. "Probing the Mechanism of Staphylococcal Nuclease with Unnatural Amino Acids: Kinetic and Structural Studies." Science, 261:1578-1581, 1993.
92. Cho, C.Y., Moran, E.J., Cherry, S.R., Stephans, J.C., Fodor, S.P.A., Adams, C.L., Sundaram, A., Jacobs, J.W., Schultz, P.G. "An Unnatural Biopolymer." Science, 261:1303-1305, 1993.
91. Schultz, P.G., Lerner, R.A. "Antibody Catalysis of Difficult Chemical Transformations." Acc. Chem. Res." 26(8):391-395, 1993, .
90. Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Role of Lysine 16 in Ras p21 Protein with Unnatural Amino Acids." J. Am. Chem. Soc., 115(14):6414-6415, 1993.
89. Mendel, D., Ellman, J., Schultz, P.G. "Protein Biosynthesis with Conformationally Restricted Amino Acids." J. Am. Chem. Soc., 115(10):4359-4360, 1993.
88. Sarvetnick, N., Gurushanthaiah, D., Han, N., Prudent, J., Schultz, P., Lerner, R. "Increasing the Chemical Potential of the Germ-line Antibody Repertoire." Proc. Nat. Acad. Sci. (USA), 90:4008-4011, 1993.
87. Hsieh, L.C., Yonkovich, S., Kochersperger, L., Schultz, P.G. "Controlling Chemical Reactivity with Antibodies." Science, 260:337-339, 1993.
86. Lesley, S.A., Patten, P.A., Schultz, P.G. "A Genetic Approach to the Generation of Antibodies with Enhanced Catalytic Activities." Proc. Natl. Acad. Sci. (USA), 90:1160-1165, 1993.
85. Skerker, P.S., Jacobs, J.W., Clark, D.S., Schultz, P.G. "Probing a Catalytic Antibody Active Site Using Spin-Labelled Haptens." BioMed. Chem. Lett., 2:285-288, 1993.
84. Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code." Science, 259:806-809, 1993.
83. Scanlan, T., Schultz, P.G. "Recent Advances in Catalytic Antibodies" Advances in Detailed Reaction Mechanisms" 2:1-22, 1992, .
82. Jackson, D.Y., Schultz, P.G. "Progress Toward the Generation of Antibodies Containing Catalytic Dyads." New Aspects of Organic Chemistry II, 21:469-475, 1992.
81. Ellman, J.A., Volkman, B.F., Mendel, D., Schultz, P.G., Wemmer, D.E. "Site-Specific Isotopic Labelling of Proteins for NMR Studies." J. Am. Chem. Soc., 114:7959-7961, 1992.
80. Schultz, P.G., Shokat, K.M. "Catalytic Antibodies: An Overview of Design Strategies and Their Applications." Welch Symposium Proceedings, pp. 19-42, 1991.
79. Rozsnyai, L., Benson, D.R., Fodor, S.P., Schultz, P.G. "Photolithographic Immobilization of Biopolymers on Solid Supports." Angew. Chem. Int. Engl. Ed., 31:759-761, 1992.
78. Uno, T., Schultz, P.G. "An Antibody-Catalyzed Dehydration Reaction." J. Am. Chem. Soc., 114:6573-6574, 1992.
77. Oldenburg, K., Loganathan, D., Goldstein, I., Schultz, P.G., Gallop, M.A. "Peptide Ligands For a Sugar Binding Protein Isolated from a Random Peptide Library." Proc. Nat. Acad. Sci. (USA), 89:5393-5397, 1992.
76. Mendel, D., Ellman, J.A., Chang, Z., Veenstra, D.L., Kollman, P.A., Schultz, P.G. "Probing Protein Stability With Unnatural Amino Acids." Science, 256:1798-1802, 1992.
75. Jacobsen, J., Schultz, P.G. "An Efficient Antibody-Catalyzed Aminoacylation Reaction." Science, 256:365-367, 1992.
74. Jackson, D.Y., Liang, M.N., Bartlett, P.A., Schultz, P.G. "Activation Parameters and Stereochemistry of an Antibody-Catalyzed Claisen Rearrangement." Angew. Chem. Int. Engl. Ed., 31:182-183, 1992.
73. Gong, B., Lesley, S., Schultz, P.G. "A Chromogenic Assay for Screening Large Antibody Libraries." J. Am. Chem. Soc., 114:1486-1487, 1992.
72. Ellman, J., Mendel, D., Schultz, P.G. "Site-Specific Incorporation of Novel Backbone Structures into Proteins." 255:197-20, 1992, .
71. Nakayama, G., Schultz, P.G. "Stereospecific Antibody-Catalyzed Reduction of an α-Keto Amide." J. Am. Chem. Soc., 114:780-781, 1992.
70. Shokat, K.M., Schultz, P.G. "Catalytic Antibodies." Methods in Enzymology, 203:327-351, 1991.
69. Ellman, J., Mendel D., Anthony-Cahill, S., Noren, C.J., Schultz, P.G. "Biosynthetic Method for Introducing Unnatural Amino Acids Site Specifically Into Proteins." Methods in Enzymology, 202:301-336, 1991.
68. Pei, D., Schultz, P.G. "Engineering Protein Specificity: Gene Manipulation with Semisynthetic Nucleases." J. Am. Chem. Soc., 113:9391-9392, 1991.
67. Scanlan, T.S., Prudent, J.R., Schultz, P.G. "Antibody-Catalyzed Hydrolysis of Phosphate Monoesters." J. Am. Chem. Soc., 113:9397-9398, 1991.
66. Jackson, D.Y., King D., Chmielewski, J., Singh, S., Schultz, P.G. "General Approach to the Synthesis of Short α-Helical Peptides." J. Am. Chem. Soc., 113:9398-9400, 1991.
65. Martin, M.T., Napper, A.D., Schultz, P.G., Rees, A.R. "Mechanistic Studies of a Tyrosine-Dependent Catalytic Antibody." Biochemistry, 30:9757-9761, 1991.
64. Pei, D., Ulrich, H., Schultz, P.G. "A Combinatorial Approach Toward DNA Recognition." Science, 25:1408-1411, 1991.
63. Cochran, A.G., Pham, T., Sugasawara, R., Schultz, P.G. "Antibody-Catalyzed Bimolecular Imine Formation." J. Am. Chem. Soc., 113:6670-6672, 1991.
62. Corey, D.R., Zuckermann, R., Schultz, P.G. "Hybrid Enzymes and the Sequence-Specific Cleavage of Nucleic Acids." in Frontiers in Bioorganic Chemistry vol. 2, H. Dugas: Berlin, pp. 3-31, 1991.
61. Martin, M.T., Schantz, A.R., Schultz, P.G., Rees, A.R. "Characterization of the Mechanism of Action of a Catalytic Antibody." Ciba Foundation Symposium, 159:188-201, 1991.
60. Shokat, K.M., Schultz, P.G. "The Generation of Antibody Combining Sites Containing Catalytic Residues." Ciba Foundation Symposium, 159:118-134, 1991.
59. Nakayama, G., Schultz, P.G. "Approaches to the Design of Semisynthetic Metal Dependent Catalytic Antibodies." Ciba Foundation Symposium, 159:72-91, 1991.
58. Scanlan, T., Schultz, P.G. "Recent Advances in Catalytic Antibodies." Philosophical Transactions of the Royal Society, 332:157-164, 1991.
57. Lerner, R.A., Benkovic, S.J., Schultz, P.G. "At the Crossroads of Chemistry and Immunology: Catalytic Antibodies" Science, 252:659-667, 1991.
56. Chmielewski, J., Schultz, P.G. "Monoclonal Antibodies with Sequence Specific Affinity for a Stem-Loop Structure in DNA." Tetrahedron Symposium in Print, 14(15):2563-2572, 1991.
55. Mendel, D., Ellman, J., Schultz, P.G. "Construction of a Light-Activated Protein by Site Directed Unnatural Amino Acid Mutagenesis." J. Am. Chem. Soc., 113:2758-2760, 1991.
54. Robertson, S.A., Ellman, J., Schultz, P.G. "A General and Efficient Route for Chemical Aminoacylation of Transfer RNAs" J. Am. Chem. Soc., 113:2722-2729, 1991.
53. Jackson, D.Y., Schultz, P.G. "An Antibody-Catalyzed Cis-Trans Isomerization." J. Am. Chem. Soc., 113:2319-2321, 1991.
52. Shokat, K.M., Schultz, P.G. "Redirecting the Immune Response: Ligand Mediated Immunogenicity." J. Am. Chem. Soc., 113:1861-1862, 1991.
51. Jackson, D., Prudent, J., Baldwin, E., Schultz, P.G. "A Mutagenesis Study of a Catalytic Antibody." Proc. Natl. Acad. Sc. (USA), 88:58-62, 1991.
50. Pollack, S.J., Schultz, P.G. "Semisynthetic Catalytic Antibodies." in Protein Design and the Development of New Therapeutics and Vaccines, (eds., J. Hook and G. Poste) Plenum, New York, pp. 371-394, 1990.
49. Pei, D., Corey, D.R., Schultz, P.G. "Site-Selective Cleavage of Duplex DNA by a Semisynthetic Nuclease via Triple-Helix Formation." Proc. Natl. Acad. Sci. (USA), 87: 9858-9862, 1990.
48. Shokat, K.M., Ko, M.K., Scanlan, T.S., Kochersperger, L., Yonkovich, S., Thaisrivongs, S., Schultz, P.G. "Catalytic Antibodies: A New Class of Transition State Analogues Used to Elicit Hydrolytic Antibodies." Angew. Chem. Int. Engl. Ed., 29:1296-1303, 1990.
47. Cochran, A., Schultz, P.G. "Peroxidase Activity of an Antibody-Heme Complex." J. Am. Chem. Soc., 112:9414-9415, 1990.
46. Braisted, A., Schultz, P.G. "An Antibody-Catalyzed Bimolecular Diels-Alder Reaction." J. Am. Chem. Soc., 112:7430-7431, 1990.
45. Cochran, A., Schultz, P.G. "Antibody-Catalyzed Porphyrin Metallation." Science, 249:781-783, 1990.
44. Schultz, P.G., Lerner, R.A., Benkovic, S.J. "Catalytic Antibodies." C&E News, 68:26-40, 1990.
43. Pei, D., Schultz, P.G. "Site-Specific Cleavage of Duplex DNA with a λ Repressor-Staphylococcal Nuclease Hybrid." J. Am. Chem. Soc., 112:4579-4580, 1990.
42. Shokat, K.M., Schultz, P.G. "Catalytic Antibodies." Ann. Rev. Immunology, 8:335-363, 1990.
41. Hoyer, D., Cho, H., Schultz, P.G. "A New Strategy for the Selective Cleavage of Proteins." J. Am. Chem. Soc., 112:3249-3250, 1990.
40. Noren, C.J., Anthony-Cahill, S.J., Suich, D.J., Noren, K.A., Griffith, M.C., Schultz, P.G. "In Vitro Suppression of an Amber Mutation by a Chemically Aminoacylated Transfer RNA Prepared by Runoff Transcription." Nucleic Acids Res., 18(1):83-88, 1989.
39. Robertson, S.A., Noren, C.J., Anthony-Cahill, S.J., Griffith, M.C., Schultz, P.G. "The Use of 5'-phospho-2'-deoxyribocytidylylriboadenosine as a Facile Route to Chemical Aminoacylation of tRNA." Nucleic Acids Res., 17(23):9649-9660, 1989.
38. Corey, D.R., Pei, D., Schultz, P.G. "Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease." J. Am. Chem. Soc., 111:8523-8525, 1989.
37. Anthony-Cahill, S.J., Griffith, M.C., Noren, C.J., Suich, D.J., Schultz, P.G. "Site-Specific Mutagenesis with Unnatural Amino Acids." Trends in Biochemical Sciences, 14(10):400-403, 1989.
36. Baldwin, E., Schultz, P.G. "Generation of a Catalytic Antibody by Site-Directed Mutagenesis." Science, 245:1104-1107, 1989.
35. Schultz, P.G. "Catalytic Antibodies." Angew. Chem. Int. Engl. Ed., 28(10):1283-1295, 1989.
34. Pollack, S.J., Hsiun, P., Schultz, P.G. "Stereospecific Hydrolysis of Alkyl Esters by Antibodies." J. Am. Chem. Soc., 111:5961-5962, 1989.
33. Corey, D.R., Pei, D., Schultz, P.G. "Generation of a Catalytic Sequence-Specific Hybrid DNase." Biochemistry, 28:8277-8286, 1989.
32. Noren, C.J., Anthony-Cahill, S.J., Griffith, M.C., Schultz, P.G. "A General Method for Site-Specific Incorporation of Unnatural Amino Acids into Proteins." Science, 244:182-188, 1989, .
31. Schultz, P.G. "Catalytic Antibodies." Accounts of Chem. Res., 22:287-294, 1989.
30. Shokat, K.M., Leumann, C., Sugasawara, R., Schultz, P.G. "A New Strategy for the Generation of Catalytic Antibodies." Nature, 338(6212):269-271, 1989.
29. Pollack, S.J., Schultz, P.G. "A Semisynthetic Catalytic Antibody." J. Am. Chem. Soc., 111:1929-1931, 1989.
28. Saha, A., Schultz, P.G., Rapoport, H. "1,1'-Carbonylbis(3-methylimidazolium) Triflate: An Efficient Method for Aminoacylations." J. Am. Chem. Soc., 111:4856-4859, 1989.
27. Pollack, S.J., Nakayama, G.R., Schultz, P.G. "Design of Catalytic Antibodies." Methods in Enzymology, 178:551-568, 1989.
26. Corey, D.R., Schultz, P.G. "Introduction of a Metal-dependent Regulatory Switch into an Enzyme." J. Biol. Chem., 264(7):3666-3669, 1989.
25. Zuckermann, R.N., Schultz, P.G. "Site-Selective Cleavage of Structured RNA by a Staphylococcal Nuclease-DNA Hybrid." Proc. Natl. Acad. Sci. (USA), 86:1766-1770, 1989.
24. Durfor, C.N., Bolin, R.J., Sugasawara, R.J., Massey, R.J., Jacobs, J.W., Schultz, P.G. "Antibody Catalysis in Reverse Micelles." J. Am. Chem. Soc., 110:8713-8714, 1988.
23. Pollack, S.J., Nakayama, G.R., Schultz, P.G. "Introducion of Nucleophiles and Spectroscopic Probes into Antibody Combining Sites." Science, 242:1038-1040, 1988.
22. Cochran, A.G., Sugasawara, R., Schultz, P.G. "Photosensitized Cleavage of a Thymine Dimer by an Antibody." J. Am. Chem. Soc., 110:7888-7890, 1988.
21. Zuckermann, R.N., Schultz, P.G. "A Hybrid Sequence-Selective Ribonuclease S." J. Am. Chem. Soc., 110:6592-6594, 1988.
20. Shokat, K.M., Leumann, C.J., Sugasawara, R., Schultz, P.G. "An Antibody-Mediated Redox Reaction." Angew. Chem. Int. Engl. Ed., 27:1172-1174, 1988.
19. Jackson, D.Y., Jacobs, J.W., Sugasawara, R., Reich, S.H., Bartlett, P.A., Schultz, P.G. "An Antibody-Catalyzed Claisen Rearrangement." J. Am. Chem. Soc., 110: 4841-4842, 1988.
18. Schultz, P.G. "The Interplay between Chemistry and Biology in the Design of Enzymatic Catalysts." Science, 240:426-433, 1988.
17. Zuckermann, R.N., Corey, D.R., Schultz, P.G. "Site-Selective Cleavage of RNA by a Hybrid Nuclease." J. Am. Chem. Soc., 110:1614-1615, 1988.
16. Corey, D.R., Schultz, P.G. "Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease." Science, 238:1401-1403, 1987.
15. Schultz, P.G., Jacobs, J.W. "Catalytic Antibodies: Generation and Characterization." Molecular Structure and Energetics, J. Liebman & A. Greenberg, (eds), VCH, Florida, 9:303-335, 1988.
14. Pollack, S.J., Schultz, P.G. "Antibody Catalysis by Transition State Stabilization." Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor, New York, 52:97-104, 1987.
13. Zuckermann, R.N., Corey, D.R., Schultz, P.G. "Efficient Methods for Attachment of Thiol Specific Probes to the 3'-ends of Synthetic Oligodeoxyribonucleotides." Nucleic Acids Res., 15(13):5305-5321, 1987.
12. Jacobs, J.W., Schultz, P.G. "Catalytic Antibodies." J. Am. Chem. Soc., 109: 2174-2176, 1987.
11. Pollack, S.J., Jacobs, J.W., Schultz, P.G. "Selective Chemical Catalysis by an Antibody." Science, 234:1570-1573, 1986.
10. Schultz, P.G., Au, K.G., Walsh, C.T. "Active Site Mutations of Mercuric Reductase." Biochemistry, 24: 6840-6837, 1985.
9. Schultz, P.G., Dervan, P.B. "Distamycin and penta-n-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving." J. Biomol. Struc. Dyn., 1:1133-1147, 1984.
8. Taylor, J. S., Schultz, P. G., Dervan, P. B. "DNA Affinity Cleaving. Sequence Specific Cleavage of DNA by Distamycin-EDTA-Fe(II) and EDTA-Distamycin•Fe(II)." Tetrahedron Symposium, 40:457-465, 1984.
7. Schultz, P.G., Dervan, P.B. "Design of Sequence Specific Double Strand DNA Cleaving Molecules. Bis(EDTA-distamycin•Fe(II) and EDTA-(Bisdistamycin)•Fe(II)." J. Am. Chem. Soc., 105:7748-7750, 1983.
6. Schultz, P.G., Dervan, P.B. "Sequence Specific Double Strand Cleavage of DNA with Penta-N-Methylpyrrolecarboxamide-EDTA•Fe(II)." Proc. Natl. Acad. Sci., 80:6834-6837, 1983.
5. Schultz, P.G., Taylor, J.S., Dervan, P.B. "Design and Synthesis of a Sequence Specific DNA Cleaving Molecule, Distamycin-EDTA.Fe(II)." J. Am. Chem. Soc., 104:6861-6863, 1982.
4. Schultz, P.G., Dervan, P.B. "Photochemistry of 1,1-Diazenes. Direct and Sensitized Photolyses of N-(2,2,5,5-Tetramethylpyr¬rolidyl)nitrene, d1-N-(2,5-Diethyl-2,5-dimethylpyrrolidyl)nitrene andN-(2,2,6,6-Tetramethylpiperdyl)-nitrene." J. Am. Chem. Soc., 104:6660-6668, 1982.
3. Hinsberg, III, W.D., Schultz, P.G., Dervan, P.B. "Direct Studies of 1,1- Diazenes Syntheses, Infrared and Electronic Spectra, and Kinetics of Thermal Decomposition of N-(2,2,6,6-Tetramethyl¬piper¬dyl)nitrenand N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene." J. Am. Chem. Soc., 104:766-773, 1982.
2. Schultz, P.G., Dervan, P.B. "Photochemistry of a 1,1-Diazene: N-(2,2,5,5-Tetramethyl¬pyrrolidyl )nitrene." J. Am. Chem. Soc., 103:1563-1567, 198.
1. Schultz, P.G., Dervan, P.B. "Synthesis and Direct Spectroscopic Observation of N-(2,2,5,5-Tetramethyl¬pyr¬rolidyl)nitrene. Comparison of Five- and Six-Membered Cyclic 1,1-Diazenes." J. Am. Chem. Soc., 102:878-880, 1980.