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Selected Recent Publications
1. Chen, S., Zhang, Q, Wu, X., Schultz, P.G., Ding, S., “Dedifferentiation of Lineage-Committed Cells by a Small Molecule,” J. Amer. Chem. Soc., 126(2):410-411, 2004.
2. Wu, X., Ding, S., Ding, Q., Gray, N.S., Schultz, P.G. “Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells,” J. Amer. Chem. Soc., 126:1590-1591, 2004.
3. Yin, J., Mills, J.H., Schultz, P.G. “A Catalysis-based Selection for Peroxidase Antibodies with Increased Activity,” J. Amer. Chem. Soc.,126(10):3006-7, 2004.
4. Zheng, L., Liu, J., Batalov, S., Zhou, D., Orth, A., Ding, S., Schultz, P.G. “An Approach to Genomewide Screens of Expressed Small Interfering RNAs in Mammalian Cells,” Proc. Natl. Acad. Sci. (USA), 101(1): 135-140, 2004.
5. Anderson, J.C., Wu, N., Santoro, S.W., Lakshman, V., King, D. S., Schultz, P.G. “An Expanded Genetic Code with a Functional Quadruplet Codon,” Proc. Natl. Acad. Sci. (USA), 101(20): 7566-7571,2004.
6. Wu, X., Walker, J., Zhang, J., Ding, S., Schultz, P.G. “Purmorphamine Induces Osteogenesis by Activation of the Hedgehog Signaling Pathway,” Chem. & Bio., 11(9):1229-38, 2004.
7. Wang, L, Schultz, P.G. “Expanding The Genetic Code,” Angew. Chem., 44(1):34-66, 2004.
8. Wu, N., Deiters, A., Cropp, T.A., Schultz, P.G., “A Genetically Encoded Photocaged Amino Acid”, J. Amer. Chem. Soc., 126 (44):14306-7, 2004.
9. Tian, F., Tsao, M.L., Schultz, P.G. “A Phage Display System With Unnatural Amino Acids,” J. Amer. Chem. Soc., 126(49):15962-3, 2004.
10. Venkateshrao, S., Yin, J., Jarzecki, A., Schultz, P.G., Spiro, T.G. “Porphyrin Distortion During Affinity-Maturation of a Ferrochelatase Antibody, Monitored by Resonance Raman Spectroscopy,” J. Amer. Chem. Soc., 126(50):16361-7, 2004.
11. Luesch, H., Wu, T.Y.H., Ren, P., Gray, N.S., Schultz, P.G., Supek, F., “A Genome-Wide Overexpression Screen in Yeast for Small Molecule Target Identification,” Chem. & Biol., 12(1):55-63, 2005.
12. Liu, J., Bang, A., Kintner, C., Orth, T., Chanda, S., Ding, S., Schultz, P.G. “Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genomewide functional analysis,” Proc. Natl.. Acad. Sci., 102(6):1927-32, 2005.
13. Willingham, A.T., Orth, A.P., Batalov, S., Peters, E.C., Wen, B.G., Aza-Blanc, P., Hogenesch, J.B., Schultz, P.G., “A Strategy for Determining the Function of Noncoding RNAs Identifies a Repressor of NFAT,” Science, 309(5740): 1570-3, 2005.
14. Bose, M., Groff, D., Xie, J., Brustad, E., Schultz, P.G. “The Incorporation of a Photoisomerizable Amino Acid into Proteins in E. coli.” J. Am. Chem. Soc., 128(2):388-9, 2005.
15. Warashina, M., Min, K.H., Kuwabara, T., Huynh, A., Gage, F.H., Schultz, P.G., Ding, S. “A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells.” Angew. Chem., 45(4):591-593, 2005.
16. Luesch, H., Chanda, S.K., Raya, R. M., Orth, A.P., Walker, J.R., Izpisúa Belmonte, J.C., Schultz, P.G. “A Functional Genomics Approach to the Mode of Action of the Antiproliferative Natural Product Apratoxin A.” Nature Chem Bio., 2(3):158-167, 2006.
17. Melnick, J.S., Janes, J., Kim, S., Chang, J.Y., Sipes, D.G., Gunderson, A., Jarnes, L., Matzen, J.T., Garcia, M.E., Hood, T.L., Beigi, R., Xia, G., Harig, R.A., Asatryan, H., Yan, S.F., Zhou, Y., Gu, X-J., Saadat, A., Zhou, V., King, F.J., Shaw, C.M., Su, A.I., Downs, R., Gray, N.S., Schultz, P.G., Warmuth, M., Caldwell, J.S. “An Efficient, Rapid System for Profiling the Cellular Activities of Molecular Libraries.” Proc. Natl. Acad. Sci., 103(9):3153–3158, 2006.
18. Turner, J.M., Graziano, J., Spraggon, G., Schultz, P.G. “Structural plasticity of an aminoacyl-tRNA synthetase active site.” Proc. Natl. Acad. Sci., 103(17):6483-8, 2006.
19. Summerer, D., Chen, S., Wu, N., Deiters, A., Chin, J., Schultz, P.G. “A Genetically Encoded, Fluorescent Amino Acid.” Proc. Natl. Acad. Sci. (USA), 103(26):9785–9789, 2006.
20. Cho, C.Y., Koo, S-H., Wang, Y., Callaway, S., Hedrick, S., Mak, P.A., Orth, A.P., Peters, E.C., Saez, E., Montminy, M., Schultz, P.G., Chanda, S.K., “Identification of the Tyrosine Phosphatase PTP-MEG2 as an Antagonist of Hepatic Insulin Signaling.” Cell Metab., 3(5):367-78, 2006.
21. Wang, J., Xie, J., Schultz, P.G. “A Genetically Encoded Fluorescent Amino Acid.” J. Am. Chem. Soc., 128(27):8738-9, 2006.
22. Mukherji, M., Cho, C., Supekova, L., Wang, Y., Batalov, S., Bell, R., Martin, C., Sahasrabuhde, S., Orth, A.P., Chanda, S.K., Schultz, P.G., “Functional Analysis of Human Genome for Cell Cycle Regulators.” Proc. Natl. Acad. Sci. (USA), 103 (40): 14819-14824, 2006.
23. Chen, S., Do, J., Zhang, Q., Yao, S., Yan, F., Peters, E., Scholer, H., Schultz, P.G., Ding, S. “Self-renewal of Embryonic Stem Cells by a Small Molecule.” Proc. Natl. Acad. Sci., 103(46):17266-17271, 2006.
24. Liu, C., Schultz, P.G. “Recombinant expression of selectively sulfated proteins in E. coli.” Nat. Biotechnol., 24(11):1436-40, 2006.
25. Liu, W., Brock, A., Chen, S., Chen, S., Schultz, P.G. “The Genetic Incorporation of Unnatural Amino Acids into Proteins in Mammalian Cells.” Nat. Methods, in press, 2007.
26. Zhang, Q., Major, M., Takanashi, S., Camp, N., Nishiya, N., Ginsberg, M., Schultz, P.G., Moon, R.T., Ding, S. “A Small Molecule Synergist of the Wnt/ß-catenin Signaling Pathway.” Nature Chemical Biology, in press, 2007.
27. Chen, S., Takanashi, S., Zhang, Q., Xiong, W., Peters, E.C., Ding, S., Schultz, P.G. “Reversine Induces Cellular Reprogramming of Lineage-Committed Mammalian Cells.” Proc. Natl. Acad. Sci. (USA), in press, 2007.