1

Schultz, P.G., Dervan, P.B. “Synthesis and Direct Spectroscopic Observation of N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene. Comparison of Five- and Six-Membered Cyclic 1,1-Diazenes.”  J. Am. Chem. Soc., 102:878-880, 1980.

2

Schultz, P.G., Dervan, P.B. “Photochemistry of a 1,1-Diazene: N-(2,2,5,5-Tetramethylpyrrolidyl )nitrene.”  J. Am. Chem. Soc., 103:1563-1567, 1981.

3

Hinsberg, III, W.D., Schultz, P.G., Dervan, P.B. “Direct Studies of 1,1- Diazenes Syntheses, Infrared and Electronic Spectra, and Kinetics of Thermal Decomposition of N-(2,2,6,6-Tetramethylpiperdyl)nitrene and N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene.”  J. Am. Chem. Soc., 104:766-773, 1982.

4

Schultz, P.G., Dervan, P.B. “Photochemistry of 1,1-Diazenes. Direct and Sensitized Photolyses of N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene, d1-N-(2,5-Diethyl-2,5-dimethylpyrrolidyl)nitrene and N-(2,2,6,6-Tetramethylpiperdyl)-nitrene.”  J. Am. Chem. Soc., 104:6660-6668, 1982.

5

Schultz, P.G., Taylor, J.S., Dervan, P.B. “Design and Synthesis of a Sequence Specific DNA Cleaving Molecule, Distamycin-EDTA.Fe(II).”  J. Am. Chem. Soc., 104:6861-6863, 1982.

6

Schultz, P.G., Dervan, P.B. “Sequence Specific Double Strand Cleavage of DNA with Penta-N-Methylpyrrolecarboxamide-EDTA•Fe(II).”  Proc. Natl. Acad. Sci., 80:6834-6837, 1983.

7

Schultz, P.G., Dervan, P.B. “Design of Sequence Specific Double Strand DNA Cleaving Molecules. Bis(EDTA-distamycin•Fe(II) and EDTA-(Bisdistamycin)•Fe(II).”  J. Am. Chem. Soc., 105:7748-7750, 1983.

8

Taylor, J. S., Schultz, P. G., Dervan, P. B. “DNA Affinity Cleaving. Sequence Specific Cleavage of DNA by Distamycin-EDTA-Fe(II) and EDTA-Distamycin•Fe(II).”  Tetrahedron Symposium, 40:457-465, 1984.

9

Schultz, P.G., Dervan, P.B. “Distamycin and penta-n-methylpyrrolecarboxamide binding sites on native DNA.  A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving.”  J. Biomol. Struc. Dyn., 1:1133-1147, 1984.

10

Schultz, P.G., Au, K.G., Walsh, C.T. “Active Site Mutations of Mercuric Reductase.”  Biochemistry, 24: 6840-6837, 1985.

11

Pollack, S.J., Jacobs, J.W., Schultz, P.G. “Selective Chemical Catalysis by an Antibody.”  Science, 234:1570-1573, 1986.

12

Jacobs, J.W., Schultz, P.G. “Catalytic Antibodies.”  J. Am. Chem. Soc., 109: 2174-2176, 1987.

13

Zuckermann, R.N., Corey, D.R., Schultz, P.G. "Efficient Methods for Attachment of Thiol Specific Probes to the 3'-ends of Synthetic Oligodeoxyribonucleotides.”  Nucleic Acids Res., 15(13):5305-5321, 1987.

14

Pollack, S.J., Schultz, P.G. "Antibody Catalysis by Transition State Stabilization."  Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor, New York, 52:97-104, 1987.

15

Jacobs, J.W., Schultz, P.G. "Catalytic Antibodies: Generation and Characterization.”  Molecular Structure and Energetics, J. Liebman & A. Greenberg, (eds), VCH, Florida, 9:303-335, 1988.

16

Corey, D.R., Schultz, P.G. "Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease"  Science, 238:1401-1403, 1987.

17

Zuckermann, R.N., Corey, D.R., Schultz, P.G. "Site-Selective Cleavage of RNA by a Hybrid Nuclease.”  J. Am. Chem. Soc., 110:1614-1615, 1988.

18

Schultz, P.G. "The Interplay between Chemistry and Biology in the Design of Enzymatic Catalysts.”  Science, 240:426-433, 1988.

19

Jackson, D.Y., Jacobs, J.W., Sugasawara, R., Reich, S.H., Bartlett, P.A., Schultz, P.G. "An Antibody-Catalyzed Claisen Rearrangement.”  J. Am. Chem. Soc., 110: 4841-4842, 1988.

20

Shokat, K.M., Leumann, C.J., Sugasawara, R., Schultz, P.G. "An Antibody-Mediated Redox Reaction.”  Angew. Chem. Int. Engl. Ed., 27:1172-1174, 1988.

21

Zuckermann, R.N., Schultz, P.G. "A Hybrid Sequence-Selective Ribonuclease S.”  J. Am. Chem. Soc., 110:6592-6594, 1988.

22

Cochran, A.G., Sugasawara, R., Schultz, P.G. "Photosensitized Cleavage of a Thymine Dimer by an Antibody.”  J. Am. Chem. Soc., 110:7888-7890, 1988.

23

Pollack, S.J., Nakayama, G.R., Schultz, P.G. "Introducion of Nucleophiles and Spectroscopic Probes into Antibody Combining Sites.”  Science, 242:1038-1040, 1988.

24

Durfor, C.N., Bolin, R.J., Sugasawara, R.J., Massey, R.J., Jacobs, J.W., Schultz, P.G. "Antibody Catalysis in Reverse Micelles.”  J. Am. Chem. Soc., 110:8713-8714, 1988.

25

Zuckermann, R.N., Schultz, P.G. "Site-Selective Cleavage of Structured RNA by a Staphylococcal Nuclease-DNA Hybrid.”  Proc. Natl. Acad. Sci. (USA), 86:1766-1770, 1989.

26

Corey, D.R., Schultz, P.G. "Introduction of a Metal-dependent Regulatory Switch into an Enzyme.”  J. Biol. Chem., 264(7):3666-3669, 1989.

27

Pollack, S.J., Nakayama, G.R., Schultz, P.G. "Design of Catalytic Antibodies.”  Methods in Enzymology, 178:551-568, 1989.

28

Saha, A., Schultz, P.G., Rapoport, H. "1,1'-Carbonylbis(3-methylimidazolium) Triflate: An Efficient Method for Aminoacylations.”  J. Am. Chem. Soc., 111:4856-4859, 1989.

29

Pollack, S.J., Schultz, P.G. "A Semisynthetic Catalytic Antibody.”  J. Am. Chem. Soc., 111:1929-1931, 1989.

30

Shokat, K.M., Leumann, C., Sugasawara, R., Schultz, P.G. "A New Strategy for the Generation of Catalytic Antibodies.”  Nature, 338(6212):269-271, 1989.

31

Schultz, P.G. "Catalytic Antibodies.”  Accounts of Chem. Res., 22:287-294, 1989.

32

Noren, C.J., Anthony-Cahill, S.J., Griffith, M.C., Schultz, P.G. "A General Method for Site-Specific Incorporation of Unnatural Amino Acids into Proteins.”  Science, 244:182-188, 1989.

33

Corey, D.R., Pei, D., Schultz, P.G. "Generation of a Catalytic Sequence-Specific Hybrid DNase.” Biochemistry, 28:8277-8286, 1989.

34

Pollack, S.J., Hsiun, P., Schultz, P.G. "Stereospecific Hydrolysis of Alkyl Esters by Antibodies.”  J. Am. Chem. Soc., 111:5961-5962, 1989.

35

Schultz, P.G. "Catalytic Antibodies.”  Angew. Chem. Int. Engl. Ed., 28(10):1283-1295, 1989.

36

Baldwin, E., Schultz, P.G. "Generation of a Catalytic Antibody by Site-Directed Mutagenesis.”  Science, 245:1104-1107, 1989.

37

Anthony-Cahill, S.J., Griffith, M.C., Noren, C.J., Suich, D.J., Schultz, P.G. "Site-Specific Mutagenesis with Unnatural Amino Acids.”  Trends in Biochemical Sciences, 14(10):400-403, 1989.

38

Corey, D.R., Pei, D., Schultz, P.G. "Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease.”  J. Am. Chem. Soc., 111:8523-8525, 1989.

39

Robertson, S.A., Noren, C.J., Anthony-Cahill, S.J., Griffith, M.C., Schultz, P.G. "The Use of 5'-phospho-2'-deoxyribocytidylylriboadenosine as a Facile Route to Chemical Aminoacylation of tRNA.”  Nucleic Acids Res., 17(23):9649-9660, 1989.

40

Noren, C.J., Anthony-Cahill, S.J., Suich, D.J., Noren, K.A., Griffith, M.C., Schultz, P.G. "In Vitro Suppression of an Amber Mutation by a Chemically Aminoacylated Transfer RNA Prepared by Runoff Transcription.”  Nucleic Acids Res., 18(1):83-88, 1989.

41

Schultz, P.G., Hoyer, D., Cho, H. "A New Strategy for the Selective Cleavage of Proteins.”  J. Am. Chem. Soc., 112:3249-3250, 1990.

42

Shokat, K.M., Schultz, P.G. "Catalytic Antibodies.”  Ann. Rev. Immunology, 8:335-363, 1990.

43

Pei, D., Schultz, P.G. "Site-Specific Cleavage of Duplex DNA with a λ Repressor-Staphylococcal Nuclease Hybrid.”  J. Am. Chem. Soc., 112:4579-4580, 1990.

44

Schultz, P.G., Lerner, R.A., Benkovic, S.J. "Catalytic Antibodies.”  C&E News, 68:26-40, 1990.

45

Cochran, A., Schultz, P.G. "Antibody-Catalyzed Porphyrin Metallation.”  Science, 249:781-783, 1990.

46

Braisted, A., Schultz, P.G. "An Antibody-Catalyzed Bimolecular Diels-Alder Reaction.”  J. Am. Chem. Soc., 112: 7430-7431, 1990.

47

Cochran, A., Schultz, P.G. "Peroxidase Activity of an Antibody-Heme Complex.”  J. Am. Chem. Soc., 112: 9414-9415, 1990.

48

Shokat, K.M., Ko, M.K., Scanlan, T.S., Kochersperger, L., Yonkovich, S., Thaisrivongs, S., Schultz, P.G. "Catalytic Antibodies: A New Class of Transition State Analogues Used to Elicit Hydrolytic Antibodies.”  Angew. Chem. Int. Engl. Ed., 29:1296-1303, 1990.

49

Pei, D., Corey, D.R., Schultz, P.G. "Site-Selective Cleavage of Duplex DNA by a Semisynthetic Nuclease via Triple-Helix Formation.”  Proc. Natl. Acad. Sci. (USA), 87: 9858-9862, 1990.

50

Pollack, S.J., Schultz, P.G. "Semisynthetic Catalytic Antibodies.” in Protein Design and the Development of New Therapeutics and Vaccines, (eds., J. Hook and G. Poste) Plenum, New York, pp. 371-394, 1990.

51

Jackson, D., Prudent, J., Baldwin, E., Schultz, P.G. "A Mutagenesis Study of a Catalytic Antibody.”  Proc. Natl. Acad. Sc. (USA), 88:58-62, 1991.

52

Shokat, K.M., Schultz, P.G. "Redirecting the Immune Response: Ligand Mediated Immunogenicity.”  J. Am. Chem. Soc., 113:1861-1862, 1991.

53

Jackson, D.Y., Schultz, P.G. "An Antibody-Catalyzed Cis-Trans Isomerization.”  J. Am. Chem. Soc., 113:2319-2321, 1991.

54

Robertson, S.A., Ellman, J., Schultz, P.G. "A General and Efficient Route for Chemical Aminoacylation of Transfer RNAs"  J. Am. Chem. Soc., 113:2722-2729, 1991.

55

Mendel, D., Ellman, J., Schultz, P.G. "Construction of a Light-Activated Protein by Site Directed Unnatural Amino Acid Mutagenesis.” J. Am. Chem. Soc., 113:2758-2760, 1991.

56

Chmielewski, J., Schultz, P.G. "Monoclonal Antibodies with Sequence Specific Affinity for a Stem-Loop Structure in DNA.”  Tetrahedron Symposium in Print, 14(15):2563-2572, 1991.

57

Lerner, R.A., Benkovic, S.J., Schultz, P.G. "At the Crossroads of Chemistry and Immunology: Catalytic Antibodies"  Science, 252:659-667, 1991.

58

Scanlan, T., Schultz, P.G., "Recent Advances in Catalytic Antibodies.”  Philosophical Transactions of the Royal Society, 332:157-164, 1991.

59

Nakayama, G., Schultz, P.G. "Approaches to the Design of Semisynthetic Metal Dependent Catalytic Antibodies.”  Ciba Foundation Symposium, 159:72-91, 1991.

60

Shokat, K.M., Schultz, P.G. "The Generation of Antibody Combining Sites Containing Catalytic Residues.”  Ciba Foundation Symposium, 159:118-134, 1991.

61

Martin, M.T., Schantz, A.R., Schultz, P.G., Rees, A.R. "Characterization of the Mechanism of Action of a Catalytic Antibody.”  Ciba Foundation Symposium, 159:188-201, 1991.

62

Corey, D.R., Zuckermann, R., Schultz, P.G. "Hybrid Enzymes and the Sequence-Specific Cleavage of Nucleic Acids.” in Frontiers in Bioorganic Chemistry vol. 2, H. Dugas: Berlin, pp. 3-31, 1991.

63

Cochran, A.G., Pham, T., Sugasawara, R., Schultz, P.G. "Antibody-Catalyzed Bimolecular Imine Formation."  J. Am. Chem. Soc., 113:6670-6672, 1991.

64

Pei, D., Ulrich, H., Schultz, P.G. "A Combinatorial Approach Toward DNA Recognition."  Science, 25:1408-1411, 1991.

65

Martin, M.T., Napper, A.D., Schultz, P.G., Rees, A.R. "Mechanistic Studies of a Tyrosine-Dependent Catalytic Antibody."  Biochemistry, 30:9757-9761, 1991.

66

Jackson, D.Y., King D., Chmielewski, J., Singh, S., Schultz, P.G. "General Approach to the Synthesis of Short a-Helical Peptides."  J. Am. Chem. Soc., 113:9398-9400, 1991.

67

Scanlan, T.S., Prudent, J.R., Schultz, P.G. "Antibody-Catalyzed Hydrolysis of Phosphate Monoesters."  J. Am. Chem. Soc., 113:9397-9398, 1991.

68

Pei, D., Schultz, P.G. "Engineering Protein Specificity: Gene Manipulation with Semisynthetic Nucleases."  J. Am. Chem. Soc., 113:9391-9392, 1991.

69

Ellman, J., Mendel D., Anthony-Cahill, S., Noren, C.J., Schultz, P.G. "Biosynthetic Method for Introducing Unnatural Amino Acids Site Specifically Into Proteins.”  Methods in Enzymology, 202:301-336, 1991.

70

Shokat, K.M., Schultz, P.G. "Catalytic Antibodies.”  Methods in Enzymology, 203:327-351, 1991.

71

Nakayama, G., Schultz, P.G. "Stereospecific Antibody-Catalyzed Reduction of an α-Keto Amide."  J. Am. Chem. Soc., 114:780-781, 1992.

72

Ellman, J., Mendel, D., Schultz, P.G. "Site-Specific Incorporation of Novel Backbone Structures into Proteins."  255:197-20, 1992.

73

Gong, B., Lesley, S., Schultz, P.G. "A Chromogenic Assay for Screening Large Antibody Libraries."  J. Am. Chem. Soc., 114:1486-1487, 1992.

74

Jackson, D.Y., Liang, M.N., Bartlett, P.A., Schultz, P.G. "Activation Parameters and Stereochemistry of an Antibody-Catalyzed Claisen Rearrangement."  Angew. Chem. Int. Engl. Ed., 31:182-183, 1992.

75

Jacobsen, J., Schultz, P.G. "An Efficient Antibody-Catalyzed Aminoacylation Reaction."  Science, 256:365-367, 1992.

76

Mendel, D., Ellman, J.A., Chang, Z., Veenstra, D.L., Kollman, P.A., Schultz, P.G. "Probing Protein Stability With Unnatural Amino Acids."  Science, 256:1798-1802, 1992.

77

Oldenburg, K., Loganathan, D., Goldstein, I., Schultz, P.G., Gallop, M.A. "Peptide Ligands For a Sugar Binding Protein Isolated from a Random Peptide Library."  Proc. Nat. Acad. Sci. (USA), 89:5393-5397, 1992.

78

Uno, T., Schultz, P.G. "An Antibody-Catalyzed Dehydration Reaction."  J. Am. Chem. Soc., 114:6573-6574, 1992.

79

Rozsnyai, L., Benson, D.R., Fodor, S.P., Schultz, P.G. "Photolithographic Immobilization of Biopolymers on Solid Supports."  Angew. Chem. Int. Engl. Ed., 31:759-761, 1992.

80

Schultz, P.G., Shokat, K.M. "Catalytic Antibodies: An Overview of Design Strategies and Their Applications."  Welch Symposium Proceedings, pp. 19-42, 1991.

81

Ellman, J.A., Volkman, B.F., Mendel, D., Schultz, P.G., Wemmer, D.E. "Site-Specific Isotopic Labelling of Proteins for NMR Studies."  J. Am. Chem. Soc., 114:7959-7961, 1992.

82

Jackson, D.Y., Schultz, P.G. "Progress Toward the Generation of Antibodies Containing Catalytic Dyads."  New Aspects of Organic Chemistry II, 21:469-475, 1992.

83

Scanlan, T., Schultz, P.G. "Recent Advances in Catalytic Antibodies" Advances in Detailed Reaction Mechanisms; 2:1-22, 1992.

84

Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code."  Science, 259:806-809, 1993.

85

Skerker, P.S., Jacobs, J.W., Clark, D.S., Schultz, P.G. "Probing a Catalytic Antibody Active Site Using Spin-Labelled Haptens."  BioMed. Chem. Lett., 2:285-288, 1993.

86

Lesley, S.A., Patten, P.A., Schultz, P.G. "A Genetic Approach to the Generation of Antibodies with Enhanced Catalytic Activities."  Proc. Natl. Acad. Sci. (USA), 90:1160-1165, 1993.

87

Hsieh, L.C., Yonkovich, S., Kochersperger, L., Schultz, P.G. "Controlling Chemical Reactivity with Antibodies."  Science, 260:337-339, 1993.

88

Sarvetnick, N., Gurushanthaiah, D., Han, N., Prudent, J., Schultz, P., Lerner, R. "Increasing the Chemical Potential of the Germ-line Antibody Repertoire."  Proc. Nat. Acad. Sci. (USA), 90:4008-4011, 1993.

89

Mendel, D., Ellman, J., Schultz, P.G. "Protein Biosynthesis with Conformationally Restricted Amino Acids."  J. Am. Chem. Soc., 115(10):4359-4360, 1993.

90

Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Role of Lysine 16 in Ras p21 Protein with Unnatural Amino Acids."  J. Am. Chem. Soc., 115(14):6414-6415, 1993.

91

Schultz, P.G., Lerner, R.A. "Antibody Catalysis of Difficult Chemical Transformations." Acc. Chem. Res., 26(8):391-395, 1993.

92

Cho, C.Y., Moran, E.J., Cherry, S.R., Stephans, J.C., Fodor, S.P.A., Adams, C.L., Sundaram, A., Jacobs, J.W., Schultz, P.G. "An Unnatural Biopolymer."  Science, 261:1303-1305, 1993.

93

Judice, J.K., Gamble, T.R., Murphy, E.C., de Vos, A.M., Schultz, P.G. "Probing the Mechanism of Staphylococcal Nuclease with Unnatural Amino Acids: Kinetic and Structural Studies."  Science, 261:1578-1581, 1993.

94

Chung, H.H., Benson, D.R., Cornish, V.W., Schultz, P.G. "Probing the Role of Loop 2 in Ras Function with Unnatural Amino Acids."  Proc. Natl. Acad. Sci. (USA), 90:10145-10149, 1993.

95

Angeles, T.S., Smith, R.G., Darsley, M.J., Sugasawara, R., Sanchez, R.I., Kenten, J., Schultz, P.G., Martin, M.T. "Isoabzymes: Structurally and Mechanistically Similar Catalytic Antibodies from the Same Immunization."  Biochemistry, 32:12128-12135, 1993.

96

Pei, D., Schultz, P.G. "Artificial Nucleases."  Nucleases, Cold Spring Harbor Laboratory, 317-340, 1993.

97

Uno, T., Gong, B., Schultz, P.G. "Stereoselective Antibody-Catalyzed Oxime Formation."  J. Am. Chem. Soc., 116:1145-1146, 1994.

98

Chung, H., Schultz, P.G. "Probing Ras Function with Unnatural Amino Acids."  Chemistry & Biology, 1:vi-vii, 1994.

99

Campbell, D.A., Gong, B., Kochersperger, L.M., Yonkovich, S., Gallop, M.A., Schultz, P.G. "Antibody-Catalyzed Prodrug Activation."  J. Am. Chem. Soc., 116:2165-2166, 1994.

100

Hsieh, L.C., Stephans, J.C., Schultz, P.G. "An Efficient Antibody-Catalyzed Oxygenation Reaction."  J. Am. Chem. Soc., 116:2167-2168, 1994.

101

Braisted, A.C., Schultz, P.G. "An Antibody-Catalyzed Oxy Cope Rearrangement."  J. Am. Chem. Soc., 116:2211-2212, 1994.

102

Yu, J., Hsieh, L.C., Kochersperger, L., Yonkovich, S., Stephans, J.C., Gallop, M.A. Schultz, P.G. "Progress Toward An Antibody Glycosidase."  Angew. Chem. Int. Engl. Ed., 33(3):339-341, 1994.

103

Shokat, K.M., Uno, T., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction."  J. Am. Chem. Soc, 116:2261-2270, 1994.

104

Cornish, V.W., Benson, D.R., Altenbach, C.A., Hideg, K., Hubbell, W.L., Schultz, P.G. "Site Specific Incorporation of Biophysical Probes into Proteins."  Proc. Natl. Acad. Sci. (USA), 91:2910-2914, 1994.

105

Huang, L., Sera, T., Schultz, P.G. "A Permutational Approach Toward Protein-DNA Recognition."  Proc. Natl. Acad. Sci. (USA), 91:3969-3973, 1994.

106

Van Vranken, D.L., Panomitros, D., Schultz, P.G. "Catalysis of Carbamate Hydrolysis by an Antibody."  Tetrahedron Letters, 35:3873-3876, 1994.

107

Prudent, J.R., Uno, T., Schultz, P.G. "Expanding the Scope of RNA Catalysis."  Science, 264:1924-1927, 1994.

108

Jacobsen, J.R., Schultz, P.G. "Antibody Catalysis of Peptide Bond Formation."  Proc. Natl. Acad. Sci. (USA), 91:5888-5892, 1994.

109

Johnsson, K., Schultz, P.G. "Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis."  J. Am. Chem. Soc., 116:7425-7426, 1994.

110

Cornish, V.W., Schultz, P.G. "A New Tool for Studying Protein Structure and Function."  Current Opinion in Structural Biology, 4:601-607, 1994.

111

Cornish, V.W., Kaplan, M.I., Veenstra, D.L., Kollman, P.A., Schultz, P.G. "Stabilizing and Destabilizing Effects of Placing α-Branched Amino Acids in Protein a-Helices."  Biochemistry, 33:12022-12031, 1994.

112

Ku, J., Schultz, P.G. "Phage Display of Catalytically Active Staphlococcal Nuclease."  Bioorg & Med. Chem., 2(12):1413-1415, 1994.

113

Thorson, J.S., Chapman, E., Murphy, E.C., Schultz, P.G. "Linear Free Energy Analysis of Hydrogen Bonding in Proteins."  J. Am. Chem. Soc., 117:1157-1158, 1995.

114

Cornish, V.W., Mendel, D., Schultz, P.G. "Probing Protein Structure and Function with an Expanded Genetic Code."  Angew. Chem. Int. Engl. Ed., 34:621-633, 1995.

115

Müller, W.T., Klein, D.L., Lee, T., Clarke, J., McEuen, P.L., Schultz, P.G. "A Strategy for the Chemical Synthesis of Nanostructures."  Science, 268:272-273, 1995.

116

Moran, E.J., Wilson, T.E., Cho, C.Y., Cherry, S.R., Schultz, P.G. "Novel Biopolymers for Drug Discovery."  Biopolymers, 37:213-219, 1995.

117

Johnsson, K., King, D.S., Schultz, P.G. "Studies on the Mechanism of Action of Isoniazid and Ethionamide in the Chemotherapy of Tuberculosis."  J. Am. Chem. Soc., 117:5009-5010, 1995.

118

Nowak, M.W., Kearney, P.C., Sampson, J.R., Saks, M.E., Labarca, C.G., Silverman, S.K., Zhong, W., Thorson, J., Abelson, J.N., Davidson, N., Schultz, P.G., Dougherty, D.A., Lester, H.A. "Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells."  Science, 268:439-442, 1995.

119

Mendel, D., Cornish, V.W., Schultz, P.G. "Site-Directed Mutagenesis with an Expanded Genetic Code."  Annu. Rev. Biophys. Biomol. Struct., 24:435-62, 1995.

120

Jacobsen, J.R., Cochran, A.G., Stephans, J.C., King, D.S., Schultz, P.G. "Mechanistic Studies of Antibody-Catalyzed Pyrmidine Dimer Photocleavage."  J. Am. Chem. Soc., 117:5453-5461, 1995.

121

Xiang, X.-D., Sun, X., Briceño, G., Lou, Y., Wang, K.-A., Chang, H., Wallace-Freedman, W.G., Chen, S.-W., Schultz, P.G. "A Combinatorial Approach to Materials Discovery."  Science, 268:1738-1740, 1995.

122

Ku, J., Schultz, P.G. "Alternate Protein Frameworks for Molecular Recognition."  Proc. Natl. Acad. Sci. (USA), 92:6552-6556, 1995.

123

Thorson, J.S., Chapman, E., Schultz, P.G. "Analysis of Hydrogen Bonding Strengths in Proteins Using Unnatural Amino Acids."  J. Am. Chem. Soc., 117:9361-9362, 1995.

124

Schultz, P.G., Lerner, R.A. "From Molecular Diversity to Catalysis: Lessons from the Immune System."  Science, 269:1835-1842, 1995.

125

Prudent, J.R., Staunton, J., Schultz, P.G. "Probing the Structural Determinants of a Catalytic RNA with Isomerase Activity" J. Am. Chem. Soc., 117:10145-10146, 1995.

126

Briceño, G., Chang, H., Sun, X., Schultz, P.G., Xiang, X.D. "A Class of Cobalt Oxide Magnetoresistance Materials Discovered With Combinatorial Synthesis."  Science, 270:273-275, 1995.

127

Cook, S.N., Jack, W.E., Xiong, X., Danley, L.E., Ellman, J.A., Schultz, P.G., Noren, C.J. "Photochemically Initiated Protein Splicing."  Angew. Chem. Int. Engl. Ed., 34(15):1629-1630, 1995.

128

Jacobsen, J.R., Schultz, P.G. "The Scope of Antibody Catalysis."  Curr. Opin. Struc. Bio., 5:818-824, 1995.

129

Ulrich, H.D., Patten, P.A., Yang, P.L., Romesberg, F.E., Schultz, P.G. "Expression Studies of Catalytic Antibodies."  Proc. Natl. Acad. Sci. (USA), 92:11907-11911, 1995.

130

Patten, P.A., Gray, N.S., Yang, P.L., Marks, C.B., Wedemayer, G.J., Boniface, J.J., Stevens, R.G., Schultz, P.G. "The Immunological Evolution of Catalysis."  Science, 271:1086-1091, 1996.

131

Cload, S.T., Liu, D.R., Pastor, R.M., Schultz, P.G. "Mutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilis."  J. Am. Chem. Soc., 118(7):1787-1788, 1996.

132

Liu, D.R., Cload, S.T., Pastor, R.M., Schultz, P.G. "Analysis of Active Site Residues in Escherichia coli Chorismate Mutase by Site-Directed Mutagenesis."  J. Am. Chem. Soc., 118(7):1789-1790, 1996.

133

Hsieh-Wilson, L.C., Xiang, X.-D., Schultz, P.G. "Lessons from the Immune System: From Catalysis to Materials Science."  Accts. Chem. Res., 29(3):164-170, 1996.

134

Sera, T., Schultz, P.G. "In Vivo Selection of Basic Region-Leucine Zipper Proteins with Altered DNA Binding Specificities."  Proc. Natl. Acad. Sci. (USA), 93:2920-2925, 1996.

135

Uno, T., Ku, J., Prudent, J.R., Huang, A., Schultz, P.G. "An Antibody-Catalyzed Isomerizaton Reaction."  J. Am. Chem. Soc., 118(16):3811-3817, 1996.

136

Ulrich, H.D., Driggers, E.M.G., Schultz, P.G. "Antibody Catalysis of Pericyclic Reactions."  Acta Chemica Scandinavica, 50:328-332, 1996.

137

Hsieh-Wilson, L.C., Schultz, P.G., Stevens, R.C. "Insights into Antibody Catalysis: Structure of an Oxygenation Catalyst at 1.9-Å Resolution."  Proc. Natl. Acad. Sci. (USA), 93:5363-5367, 1996.

138

Fan, E., Oei, Y., Sweet, E., Uno, T., Schultz, P.G. "Antibodies with Thiol-s-Transferase Activity."  J. Am. Chem. Soc., 118: 5474-5475, 1996.

139

Flanagan, M.E., Jacobsen, J.R., Sweet, E., Schultz, P.G. "Antibody-Catalyzed Retro-Aldol Reaction."  J. Am. Chem. Soc., 118(23):6078-6079, 1996.

140

Conn, M.M., Prudent, J.R., Schultz, P.G. "Porphyrin Metalation Catalyzed by a Small RNA Molecule."  J. Am. Chem. Soc., 118(25):7012-7013, 1996.

141

Norman, T.C., Gray, N.S., Koh, J.T., Schultz, P.G. "A Structure-Based Library Approach to Kinase Inhibitors."  J. Am. Chem. Soc., 118(29):7430-7431, 1996.

142

Wei, T., Xiang, X.-D., Wallace-Freedman, W.G., Schultz, P.G. "Scanning Tip Microwave Near Field Microscope."  Appl. Phys. Lett., 68(24):3506-3508, 1996.

143

Cornish, V.W., Hahn, K.M., Schultz, P.G. "Site-Specific Protein Modification Using a Ketone Handle."  J. Am. Chem. Soc., 118(34):8150-8151, 1996.

144

Alivisatos, A.P., Johnsson, K.P., Peng, X., Wilson, T.E., Loweth, C.J., Bruchez, Jr. M.P., Schultz, P.G. "Organization of ‘Nanocrystal Molecules’ Using DNA."  Nature, 382:609-611, 1996.

145

Prudent, J.R., Schultz, P.G. "RNA Catalysis and Transition State Stabilization."  Nucleic Acids and Mol. Biology; (Edt., F. Eckstein and D.M.J. Lilley: Berlin), 10:383-395, 1996.

146

Kim, J.M., Bi, Y., Paikoff, S.J., Schultz, P.G. "The Solid Phase Synthesis of Oligoureas."  Tet. Lett., 37(30):5305-5308, 1996.

147

Kim, J.M., Wilson, T.E., Norman, T.C., Schultz, P.G. "Synthesis of a Cyclic Urea as a Nonnatural Biopolymer Scaffold."  Tet. Lett., 37(30):5309-5312, 1996.

148

Paikoff, S.J., Wilson, T.E., Cho, C.Y., Schultz, P.G. "The Solid Phase Synthesis of N-Alkylcarbamate Oligomers."  Tet. Lett., 37(32):5653-5656, 1996.

149

Bi, Y., Schultz, P.G. "Building Blocks for Peptide and Carbamate Libraries."  Bioorg. Med. Chem. Lett., 6(19):2299-2300, 1996.

150

Driggers, E.M., Schultz, P.G. "Catalytic Antibodies."  Adv. Protein Chem, 49:261-287, 1996.

151

Yoon, S.S., Oei, Y., Sweet, E., Schultz, P.G. "An Antibody-Catalyzed [2,3]-Elimination Reaction."  J. Am. Chem. Soc., 118(46):11686-11687, 1996.

152

Stevens, R.C., Hsieh-Wilson, L.C., Santarsiero, B.D., Wedemayer, G.J., Spiller, B., Wang, L.H., Barnes, D., Ulrich, H.D., Patten, P.A., Romesberg, F.E., Schultz, P.G. "Structural Studies of Catalytic Antibodies."  Israel J. of Chem., 36:121-132, 1996.

153

Cload, S.T., Liu, D.R., Froland, W.A., Schultz, P.G. "Development of Improved tRNAs for In Vitro Biosynthesis of Proteins Containing Unnatural Amino Acids."  Chem. & Biology, 3:1033-1038, 1996.

154

Kanamori, T., Nishikawa, S.-I., Shin, I., Schultz, P.G., Endo, T. "Probing the Environment Along the Protein Import Pathways in Yeast Mitochondria by Site-Specific Photocrosslinking."  Proc. Natl. Acad. Sci. (USA), 94:485-490, 1997.

155

Peng, X., Wilson, T.E., Alivisatos, A.P., Schultz, P.G. "Synthesis and Isolation of a Homodimer of Cadmium Selenide Nanocrystals."  Angew. Chem. Int. Engl. Ed., 36(112):145-147, 1997.

156

Johnsson, K., Froland, W.A., Schultz, P.G. "Overexpression, Purification and Characterization of the Catalase-Peroxidase KatG from Mycobacterium tuberculosis."  J. Biol. Chem., 272(5):2834-2840, 1997.

157

Gray, N.S., Kwon, S., Schultz, P.G. "Combinatorial Synthesis of 2,9-Substituted Purines."  Tet. Lett., 38(7):1161-1164, 1997.

158

Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C. "Crystal Structures of the Free and Liganded Form of an Esterolytic Catalytic Antibody."  J. Mol. Biol., 268:390-400, 1997.

159

Wedemayer, G.J., Patten, P.A., Wang, L.H., Schultz, P.G., Stevens, R.C. "Structural Insights into the Evolution of an Antibody Combining Site."  Science, 276:1665-1669, 1997.

160

Sun, X.D., Gao, C., Wang, J., Xiang, X.-D., Schultz, P.G. "Identification and Optimization of Advanced Phosphors Using Combinatorial Libraries." Appl. Phys. Lett., 70:1-4, 1997.

161

Chapman, E., Thorson, J.S., Schultz, P.G. "Mutational Analysis of Backbone Hydrogen Bonds in Staphylococcal Nuclease."  J. Am. Chem. Soc., 119(30):7151-7152, 1997.

162

Lu, Y., Wei, T., Duewer, F., Lu, Y., Ming, N.B., Schultz, P.G., Xiang, X.D. "Nondestructive Imaging of Dielectric-Constant Profiles and Ferroelectric Domains with a Scanning-Tip Microwave Near-field Microscope."  Science, 276:2004-2006, 1997.

163

Park, Y., Luo, J., Schultz, P.G., Kirsch, J.F. "Noncoded Amino Acid Replacement Probes of the Aspartate Aminotransferase Mechanism."  Biochemistry, 36(34):10517-10525, 1997.

164

Liu, D.R., Magliery, T.J., Pastrnak, M., Schultz, P.G. "Engineering a tRNA and Aminoacyl-tRNA Synthetase for the Site-Specific Incorporation of Unnatural Amino Acids into Proteins in Vivo." Proc. Nat. Acad. Sci.(USA), 94:10092-10097, 1997.

165

Ulrich, H.D., Mundorff, E., Santarsiero, B.D., Driggers, E.M., Stevens, R.C., Schultz, P.G. "The Interplay Between Binding Energy and Catalysis in the Evolution of a Catalytic Antibody."  Nature, 389:271-275, 1997.

166

Koh, J.T., Cornish, V.W., Schultz, P.G. "An Experimental Approach to Evaluating the Role of Backbone Interactions in Proteins Using Unnatural Amino Acid Mutagenesis."  Biochemistry, 36(38):11314-11322, 1997.

167

Xiang, X.-D., Schultz, P.G. "The Combinatorial Synthesis and Evaluation of Functional Materials."  Physica C, 282:428-430, 1997.

168

Liu, D.R., Magliery, T.J., Schultz, P.G. "Characterization of an ‘Orthogonal’ Suppressor tRNA Derived from E. coli tRNA2Gln."  Chem. & Biology, 4:685-691, 1997.

169

Yu, J., Choi, S.Y., Lee, S., Yoon, H.J., Jeong, S., Mun, H., Park, H., Schultz, P.G. "Antibody-Catalyzed Glycosyl Transfer Reactions From In Vitro Immunization."  Chem. Commun., 20:1957-1958, 1997.

170

Hall, D.G., Schultz, P.G. "Synthesis of Diverse Ethoxyformacetal Oligomers. Toward Libraries of Metal-Coordinating Unnatural Biopolymers."  Tetrahedron Lett., 38(45):7825-7828, 1997.

171

Sun, X.-D., Wang, K-A., Yoo, Y., Wallace-Freedman, W.G., Gao, C., Xiang, X-D., Schultz, P.G. "Solution-Phase Synthesis of Luminescent Materials Libraries."  Adv. Materials, 9(13):1046-1049, 1997.

172

Shin, I., Ting, A.Y., Schultz, P.G. "Analysis of Backbone Hydrogen Bonding in a β-turn of Staphylococcal Nuclease."  J. Am. Chem. Soc., 119(51):12667-12668, 1997.

173

Ulrich, H.D., Schultz, P.G. "Analysis of Hapten Binding and Catalytic Determinants in a Family of Catalytic Antibodies."  J. Mol. Biol., 275:95-111, 1998.

174

Ulrich, H.D., Moore, F.L., Schultz, P.G. "Germline diversity within the mouse Igk-V9 gene family." Immunogenetics, 47:91-95, 1997.

175

Yu, J., Choi, S.Y., Moon, K-D., Chung, H-H., Youn, H.J., Jeong, S., Park, H., Schultz, P.G. "A Glycosidase Antibody Elicited Against a Chair-like Transition State Analog Using in vitro Immunization."  Proc. Nat. Acad. Sci. (USA), 95:2880-2884, 1998.

176

Barrett, J.E., Maltby, D.A., Santi, D.V., Schultz, P.G. "Trapping of the C5 Methylene Intermediate in Thymidylate Synthase."  J. Am. Chem. Soc., 120(2):449-450, 1998.

177

Thorson, J.S., Shin, I., Chapman, E., Stenberg, G., Mannervik, B., Schultz, P.G. "Analysis of the Role of the Active Site Tyrosine in Human Glutathione Transferase A1-1 by Unnatural Amino Acid Mutagenesis."  J. Am. Chem. Soc., 120(2):451-452, 1998.

178

Blackwood, M.E., Jr., Rush, T.S. III, Romesberg, F., Schultz, P.G., Spiro, T.G. "Alternative Modes of Substrate Distortion in Enzyme and Antibody Catalyzed Ferrochelation Reactions."  Biochemistry, 37(3):779-782, 1998.

179

Wang, J., Yoo, Y., Gao, C., Takeuchi, I., Sun, X., Chang, H., Xiang, X.-D., Schultz, P.G. "Identification of a Blue Photoluminescent Composite Material from a Combinatorial Library."  Science, 279:1712-1714, 1998.

180

Schultz, P.G., Xiang, X.D. "Combinatorial Approaches to Materials Science."  Curr. Opin. Solid State and Mat. Sci., 3:153-158, 1998.

181

Romesberg, F.E., Spiller, B., Schultz, P.G., Stevens, R.C. "Immunological Origins of Binding and Catalysis in a Diels-Alderase Antibody."  Science, 279:1929-1933, 1998.

182

Driggers, E.M., Cho, H.S., Liu, C.W., Katzka, C.P., Braisted, A.C., Ulrich, H.D., Wemmer, D.E., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Pericyclic Rearrangement."  J. Am. Chem. Soc., 120(9):1945-1958, 1998.

183

Chang, H., Gao, C., Takeuchi, I., Yoo, Y., Wang, J., Schultz, P.G., Xiang, X.D., Sharma, R.P., Downes, M., Venkatesan, T. "Combinatorial Synthesis and High Throughput Evaluation of Ferroelectric/Dielectric Thin-Film Libraries for Microwave Applications."  Appl. Phys. Lett., 72(17):2185-2187, 1998.

184

Ma, L., Hsieh-Wilson, L.C., Schultz, P.G. "Antibody Catalysis of Peptidyl-prolyl cis-trans Isomerization in the Folding of RNase T1."  Proc. Natl. Acad. Sci. (USA), 95:7251-7256, 1998.

185

Romesberg, F.E., Flanagan, M.E., Uno, T., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction."  J. Am. Chem. Soc., 120(21):5160-5167, 1998.

186

Ting, A.Y., Shin, I., Lucero, C., Schultz, P.G. "Energetic Analysis of an Engineered Cation-π Interaction in Staphylococcal Nuclease."  J. Am. Chem. Soc., 120(28):7135-7136, 1998.

187

Driggers, E.M., Liu, C.W., Wemmer, D.E., Schultz, P.G. "Structure of the Michaelis Complex of an Efficient Antibody Acyl Transferase Determined by Transferred Nuclear Overhauser Enhancement Spectroscopy."  J. Am. Chem. Soc., 120(29):7395-7396, 1998.

188

Cho, C.Y., Youngquist, R.S., Paikoff, S.J., Beresini, M.H., Hebert, A.R., Berleau, L.T., Liu, C.W., Wemmer, D.E., Keough, T., Schultz, P.G. "Synthesis and Screening of Linear and Cyclic Oligocarbamate Libraries. Discovery of High Affinity Ligands for GP11b/IIIa."  J. Am. Chem. Soc., 120(31):7706-7718, 1998.

189

Thorson, J.S., Cornish, V.W., Barrett, J.E., Cload, S.T., Yano,T., Schultz, P.G. "A Biosynthetic Approach for the Incorporation of Unnatural Amino Acids into Proteins."  Methods in Molecular Biology, 77:43-73, 1998.

190

Gray, N.S. Wodicka, L., Thunnissen, A.M. W.H., Norman, T.C., Kwon, S., Hernan Espinoza, F., Morgan, D.O., Barnes, G., LeClerc, S., Meijer, L., Kim, S.H., Lockhart, D. J., Schultz, P.G. "Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors."  Science, 281:533-538, 1998.

191

Pedersen, H., Hölder, S., Sutherlin, D.P., Schwitter, U., King, D.S., Schultz, P.G. "A Method for Directed Evolution and Functional Cloning of Enzymes."  Proc. Natl. Acad. Sci. (USA), 95:10523-10528, 1998.

192

Pollitt, S.K., Schultz, P.G. "A Photochemical Switch for Controlling Protein-Protein Interactions."  Angew. Chem. Int. Engl. Ed., 37(15):2104-2107, 1998.

193

Romesberg, F.E., Santarsiero, B.D., Spiller, B., Yin J., Barnes, D., Schultz, P.G., Stevens, R.S. "Structural and Kinetic Evidence for Strain in Biological Catalysis."  Biochemistry, 37(41):14404-14409, 1998.

194

Isaacs, E.D., Marcus, M.A., Aeppli, G., Xiang, X.-D., Sun, X., Schultz, P.G., Kao, M., Cargill, G.S. III, Haushalter, R. "Synchrotron X-ray Microbeam Diagnostics of Combinatorial Synthesis."  Applied Physics Letters, 73:1820-1822, 1998.

195

I. Takeuchi, H. Chang, C. Gao, P.G. Schultz, X.-D. Xiang, R.P. Sharma, M.J. Downes, T. Venkatesan "Combinatorial Synthesis and Evaluation of Epitaxial Ferroelectric Device Libraries.”  Applied Physics Letters, 73(31):894, 1998.

196

Loweth, C.J., Caldwell, W.B., Peng, X., Alivisatos, A.P., Schultz, P.G. "DNA-Based Assembly of Gold Nanocrystals."  Angew. Chem. Int. Engl. Ed., 38(12):1808-1812, 1999.

197

Rosania, G.R., Merlie, J.Jr, Gray, N., Chang, Y.T., Schultz, P.G., Heald, R. "A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: Biochemical identification using Xenopus egg extracts."  Proc. Natl. Acad. Sci. (USA), 96:4797-4802, 1999.

198

Liu, Y., Barrett, J.E., Schultz, P.G., Santi, D.V. "Tyrosine 146 of Thymidylate Synthase Assists Proton Abstraction from the 5-Position of 2'-Deoxyuridine 5'-Monophosphate."  Biochemistry, 38:848-852, 1999.

199

Cho, C.Y., Liu, C.W., Wemmer, D.E., Schultz, P.G. "Cyclic and Linear Oligocarbamate Ligands for Human Thrombin."  Bioorganic & Medicinal Chemistry, 7:1171-1179, 1999.

200

Ha, T., Ting, A.Y., Liang, J., Caldwell, W.B., Deniz, A.A., Chemla, D.S., Schultz, P.G., Weiss, S. "Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism."  Proc. Natl. Acad. Sci. (USA), 96:893-898, 1999.

201

Liu, D.R., Schultz, P.G. "Generating New Molecular Function: A Lesson From Nature."  Angew. Chem. Int. Engl. Ed., 38:36-54, 1999.

202

Chang, Y.T., Gray, N.S., Rosania, G.R., Sutherlin, D.P., Kwon, S., Norman, T.C., Sarohia, R., Leost, M., Meijer, L., Schultz, P.G. "Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors."  Chemistry & Biology, 6:361-375, 1999.

203

Liu, D.R., Schultz, P.G. "Progress toward the evolution of an organism with an expanded genetic code."  Proc. Natl. Acad. Sci. (USA), 96:4780-4785, 1999.

204

Kanamori, T., Nishikawa, S.I., Nakai, M., Shin, I., Schultz, P.G., Endo, T. "Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane."  Proc. Natl. Acad. Sci. (USA), 96:3634-3639, 1999.

205

Romesberg, F.E., Schultz, P.G. "A Mutational Study of a Diels-Alderase Catalytic Antibody."  Bioorg. Med. Chem. Lett., 9:1741-1744, 1999.

206

Yao, S., Anex, D.S., Caldwell, W.B., Arnold, D.W., Smith, K.B, Schultz, P.G. "SDS capillary gel electrophoresis of proteins in microfabricated channels."  Proc. Natl. Acad. Sci. (USA), 96:5372-5377, 1999.

207

Deniz, A.A., Dahan, M., Grunwell, J.R., Ha, T., Faulhaber, A.E., Chemla, D.S., Weiss, S., Schultz, P.G. “Single Pair Fluorescence Resonance Energy Transfer on Freely Diffusing Molecules: Observation of Förster Distance Dependence and Subpopulations.”  Proc. Natl. Acad. Sci. (USA), 96:3670-3675, 1999.

208

Dahan, M., Deniz, A.A., Ha, T., Chemla, D.S., Schultz, P.G., Weiss, S. “Ratiometric Measurement and Identification of Single Diffusing Molecules.”  Chemical Physics, 247:85-106, 1999.

209

Barrett, J.E., Lucero, C.M., Schultz, P.G. “A Model for Hydride Transfer in Thymidylate Synthase Based on Unnatural Amino Acid Mutagenesis."  J. Am. Chem. Soc., 121(34):7965-7966, 1999.

210

Chang, Y.-T., Schultz, P.G. "Versatile Fluorescence Labeling Method Using Activated Esters on Solid Support.”  Bioorg. Med. Chem. Lett., 9:2479-2482, 1999.

211

Ma, L., Sweet, E.H., Schultz, P.G. “Selective Antibody-Catalyzed Solvolysis of endo-2-Norbornyl Mesylate.”  J. Am. Chem. Soc., 121:10227-10228, 1999.

212

Martin, A., Schultz, P.G. “Opportunities at the Interface of Chemistry and Biology.”  TiBS, 24:M24-M28, 1999.

213

Yang, P.L., Schultz, P.G. “Mutational Analysis of the Affinity Maturation of Antibody 48G7.”  J. Mol. Bio., 294:1191-1201, 1999.

214

Ha, T.J., Ting, A.Y., Liang, J., Deniz, A.A., Chemla, D.S., Schultz, P.G., Weiss, S. “Temporal Fluctuations of Fluorescence Resonance Energy Transfer Between Two Dyes Conjugated to a Single Protein.”  Chemical Physics, 247(1):107-118, 1999.

215

McMinn, D.L., Ogawa, A.K., Wu, Y., Liu, J., Schultz, P.G., Romesberg, F.E. “Efforts Toward Expansion of the Genetic Alphabet: DNA Polymerase Recognition of a Highly Stable, Self-Pairing Hydrophobic Base.”  J. Am. Chem. Soc., 121(49):11585-11586, 1999.

216

Mundorff, E.C., Hanson, M.A., Varvak, A., Ulrich H., Schultz, P.G., Steven, R.C. “Conformational Effects in Biological Catalysis: An Antibody-Catalyzed Oxy-cope Rearrangement.”  Biochemistry, 39(4):627-632, 2000.

217

Rosania, G.R., Chang, Y.T., Perez, O., Sutherlin, D., Dong, H., Lockhart, D. J., Schultz, P.G. “Myoseverin: A Microtubule-Binding Molecule with Novel Cellular Effects.”  Nat. Biotech., 18:304-308, 2000.  

218

Ly, D.H., Lockhart, D.J., Lerner, R.A., Schultz, P.G. “Mitotic Misregulation and Human Aging.”  Science, 287:2486-2492, 2000.

219

Armstrong, J.I., Portley, A.R., Chang, Y.T., Nierengarten, D.M., Cook, B.N., Bowman, K.G., Bishop, A., Gray, N.S., Shokat, K.M., Schultz, P.G., Bertozzi, C.R. “Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library.”  Angew. Chem. Int. Ed., 39(7):1303-1306, 2000.  

220

Deniz, A.A., Laurence, T.A., Beligere, G.S., Dahan, M., Martin, A.B., Chemla, D.S., Dawson, P.E., Schultz, P.G., Weiss, S. “Single-molecule Protein Folding: Diffusion Fluorescence Resonance Energy Transfer Studies of the Denaturation of Chymotrysin Inhibitor 2.”  Proc. Natl. Acad. Sci. (USA), 97(10):5179-5184, 2000.  

221

Knockaert, M., Gray, N., Damiens, E., Chang, Y.T., Grellier, P., Grant, K., Fergusson, D., Mottram, J., Soete, M., Dubremetz, J.F., Le Roch, K., Doerig, C., Schultz, P.G., Meijer, L. “Intracellular Targets of Cyclin-dependent Kinase Inhibitors: Identification By Affinity Chromatography Using Immobilised Inhibitors.”  Chemistry & Biology, 7:411-422, 2000.  

222

Ogawa, A.K., Wu, Y., McMinn, D. L., Liu, J., Schultz, P.G., Romesberg, F.E. “Efforts Toward the Expansion of the Genetic Alphabet: Information Storage and Replication with Unnatural Hydrophobic Base Pairs.”  J. Am. Chem. Soc., 122:3274-3287, 2000.

223

Guo Z., Zhou, D., Schultz, P.G. “Designing Small Molecule Switches for Protein-Protein Interactions.”  Science, 288:2042-2045, 2000. 

224

Wang, L., Magliery, T.J., Liu, D.R., Schultz, P.G. “A New Functional Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for the in vivo Incorporation of Unnatural Amino Acids into Proteins.”  J. Am. Chem. Soc., 122:5010-5011, 2000.

225

Berger, M., Ogawa, A.K., McMinn, D.L., Wu, Y., Schultz, P.G., Romesberg, F.E. “Stable and Selective Hybridization of Oligonucleotides with Unnatural Hydrophobic Bases.”  Angew. Chem. Int. Ed., 39(16):2940-2942, 2000.  

226

Wu, Y., Ogawa, A.K., Berger, M., McMinn, D.L., Schultz, P.G., Romesberg, F.E. “Efforts Toward Expansion of the Genetic Alphabet: Optimization of Interbase Hydrophobic Interactions.”  J. Am. Chem. Soc., 122(32):7621-7632, 2000.

227

Berger, M., Wu, Y., Ogawa, A.K., McMinn, D.L., Schultz, P.G., Romesberg, F.E. “Universal Bases for Hybridizaton, Replication and Chain Termination.”  Nucleic Acids Res., 28(15):2911-2914, 2000.   

228

Ogawa, A.K., Wu, Y., Berger, M., Schultz, P.G., Romesberg, F.E. “Rational Design of an Unnatural Base Pair with Increased Kinetic Selectivity.”  J. Am. Chem. Soc., 122:8803-8804, 2000.

229

Bishop, A.C., Ubersax, J.A., Petsch, D.T., Matheos, D.P., Gray, N.S., Blethrow, J., Shimizu, E., Tsien, J.Z., Schultz, P.G., Rose, M.D., Wood, J.L., Morgan, D.O., Shokat, K.M. “A Chemical Switch for Inhibitor-sensitive Alleles of any Protein Kinase.”  Nature, 407:395-401, 2000. 

230

Meggers, E., Holland, P.L., Tolman, W.B., Romesberg, F.E., Schultz, P.G. “A Novel Copper-Mediated DNA Base Pair.”  J. Am. Chem. Soc., 122:10714-10715, 2000.

231

Pastrnak, M., Magliery, T.J., Schultz, P.G. “A New Orthogonal Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for Evolving an Organism with an Expanded Genetic Code.”  Helvetica Chimica Acta, 83:2277-2286, 2000.

232

Rampon, C., Jiang, C.H., Dong, H., Tang, Y. Lockhart, D.J., Schultz, P.G., Tsien, J.Z., Hu, Y. “The Effects of Environmental Enrichment on Gene Expression in the Brain.”  Proc. Nat. Acad. Sci. (USA), 97(23):12880-12884, 2000.    

233

Simeonov, A., Matsushita, M., Juban, E.A., Thompson, E.H.Z., Hoffman, T.Z., Beuscher IV, A.E., Taylor, M.J., Wirsching, P., Rettig, W., McCusker, J.K., Stevens, R.C., Millar, D.P., Schultz, P.G., Lerner, R.A., Janda, K.D. “Blue-Fluorescent Antibodies.” Science, 290:307-313, 2000.   

234

Harmse, L., van Zyl, R., Gray, N., Schultz, P.G., Leclerc, S., Meijer, L., Doerig, C., Havlik, I. “Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.”  Biochem. Pharmacol., 62:341-348, 2001.   

235

Deniz, A.A., Laurence, T.A., Dahan, M., Chemla, D.S., Schultz, P.G., Weiss, S. “Ratiometric Single-Molecule Studies of Freely Diffusing Biomolecules.” Annual Reviews of Physical Chemistry, 52:233-253, 2001.  

236

Simbulan-Rosenthal, C.M., Ly, D.H., Rosenthal, D.S., Konopka, G., Luo, R., Wang, Z.-Q., Schultz, P.G., Smulson, M.E. “Misregulation of Gene Expression in Primary Fibroblasts Lacking poly(ADP-ribose) Polymerase.”  Proc. Nat. Acad. Sci. (USA), 97(21):11274-11279, 2001. 

237

Jiang, C.H., Tsien, J.Z., Schultz, P.G., Hu, Y. “The Effects of Aging on Gene Expression in the Hypothalamus and Cortex of Mice.” Proc. Nat. Acad. Sci., (USA), 98(4):1930-1934, 2001.  

238

Lu, T., Ting, A., Mainland, J., Jan, L.Y., Schultz, P.G., Yang, J. “Probing Ion Permeation and Gating in a K+ Channel with Backbone Mutations in the Selectivity Filter.”  Nature Neuroscience, 4(3):239-246, 2001.   

239

Magliery, T.J., Anderson, J.C., Schultz, P.G. “Expanding the Genetic Code: Selection of Efficient Suppressors of Four-Base Codons and Identification of “Shifty.” Four-Base Codons with a Library Approach in Escherichia coli.”  J. Mol. Biol., 307:755-769, 2001.  

240

Wang, L., Brock, A., Herberich, B., Schultz, P.G. “Expanding the Genetic Code of Escherichia coli.”  Science, 292:498-500, 2001.

241

Verdugo, D.E., Cancilla, M.T., Ge, X., Gray, N.S., Chang, Y.T., Schultz, P.G., Negishi, Masahiko, Leary, J.A., Bertozzi, C.R. “Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen.”  J. Med. Chem., 44:2683-2686, 2001.    

242

Hogenesch, J.B., Ching, K.A., Batalov, S., Su, A.I., Walker, J.R., Zhou, Y., Kay, S.A., Schultz, P.G. Cooke, M.P. “A Comparision of the Celera and Ensembl Predicted Gene Sets Reveals Little Overlap in Novel Genes.”  Cell, 106:1-3, 2001.   

243

Watanabe, C., Wolffram, S., Ader, P., Rimbach, G., Packer, L., Maguire, J., Schultz, P.G., Gohil, K. “The In vivo Neuromodulatory Effects of the Herbal Medicine Ginkgo Biloba.”  Proc. Nat. Acad. Sci., (USA) 98(12):6577-6580, 2001.

244

Winssinger, N., Harris, J.L., Backes, B.J., Schultz, P.G. “From Split-Pool Libraries to Spatially Addressable Microarrays and its Application to Functional Proteomic Profiling.”  Angew.  Chem., Int. Engl. Ed. 40(17):3152-3155, 2001.

245

Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G. “A Comparative Analysis of the Immunological Evolution of Antibody 28B4.”  Biochemistry, 40(36):10764-10773, 2001.    

246

Spence, M.M., Rubin,S.M., Dimitrov, I.E., Ruiz, E.J., Wemmer, D.E., Pines, A., Yao, S.Q.,  Tian, F., Schultz, P.G. “Functionalized Xenon as a Biosensor.”  Proc. Nat. Acad. Sci., (USA) 98(19):10654-10657, 2001.

247

Wang, L., Schultz, P.G. “A General Approach for the Generation of Orthogonal tRNAs.”  Chemistry and Biology, 8:883-890, 2001. 

248

Pastrnak, M., Schultz, P.G. “Phage Selection for Site-Specific Incorporation of Unnatural Amino Acids into Proteins in vivo.”  Bioorganic and Med. Chem., 9:2373-2379, 2001.  

249

Su, A.I., Welsh, J.B., Sapinosa, L.M., Kern, S.G., Dimitrov., P., Lapp, H., Schultz, P.G., Powell, S.M., Moskaluk, C.A., Frierson, H.F. Jr., Hampton, G.M. “Molecular Classification of Human Carcinomas by Use of Gene Expression Signatures.”  Cancer Research, 61:7388-7393, 2001.   

250

Grunwell, J.R., Glass, J.L., Lacoste, T.D., Ashok, A.D., Chemla, D.S., Schultz, P.G. “Monitoring the Conformational Fluctuations of DNA Hairpins Using Single-Pair Fluorescence Resonance Energy Transfer.”  J. Am. Chem. Soc., 123:4295-4303, 2001.

251

Tae, E.L., Wu, Y., Xia, G., Schultz, P.G., Romesberg, F.E. “Efforts toward Expansion of the Genetic Alphabet: Replication of DNA with Three Base Pairs.”  J. Am. Chem. Soc., 123:7439-7440, 2001.  

252

Ding, S., Ding, Q., Gray, N.S., Schultz, P.G. “Expanding the Diversity of Purine Libraries.”  Tetrahedron Letters, 42:8751-8755, 2001.

253

Wu, T.Y.H., Ding, S., Gray, N.S., Schultz, P.G. “Solid-Phase Synthesis of 2,3,5-Trisubstituted Indoles.”  Organic Letters, 3(24):3827-3830, 2001.  

254

Lin, Q., Jiang, F., Schultz, P.G., Gray, N.S. “Design of Allele-Specific Protein Methyltransferase Inhibitors.”  J. Am. Chem. Soc., 123(47):11608-11613, 2001.  

255

Atwell, S., Meggers, E., Spraggon, G., Schultz, P.G. “Structure of a Copper-Mediated Base Pair  in DNA.”  J. Am. Chem. Soc., 123(49):12364-12367, 2001.  

256

Mody, M., Cao, Y., Cui, Z., Tay, K.Y., Shyong, A., Shimizu, E., Pham, K., Schultz, P.G., Welsh, D., Tsien, J.Z. “Genome-Wide Gene Expression Profiles of the Developing Mouse Hippocampus.”  Proc. Nat. Acad. Sci., (USA), 98(15): 8862-8867, 2001.  

257

Ting, A.Y., Witte, K., Shah, K., Kraybill, B., Shokat, K., Schultz, P.G. “Phage-Display Evolution of Tyrosine Kinases with Altered Nucleotide Specificity.”  Biopolymers, 60:220-228, 2001. 

258

Ding, S., Gray, N. S., Ding, Q., Schultz, P.G. “A Concise and Traceless Linker Strategy toward Combinatorial Libraries of 2,6,9-Substituted Purines.”  J. Org. Chem., 66:8273-8276, 2001.   

259

Chang, Y.T., Wignall, S.M., Rosania, G.R., Gray N.S., Hanson, S.R., Su, A.I., Merlie, J., Moon, H.S., Sangankar, S.B., Perez, O., Heald, R., Schultz, P.G. “Synthesis and Biological Evaluation of Myoseverin Derivatives: Microtubule Assembly Inhibitors.”  J. Med. Chem., 4(26):4497-4500, 2001.   

260

Liu, D., Schultz, P.G. “Generating New Molecular Function: A Lesson from Nature.” Essays in Contemporary Chemistry: From Molecular Structure Towards Biology, (Quinkert, G., Kisakürek, M.V., eds.),Wiley-VCH, pp.341-380, 2001.

261

Block-Alper, L., Webster, P., Zhou, X., Supekova, L., Wong, W.H., Schultz, P.G., Meyer, D.I. “INO2, a Positive Regulator of Lipid Biosynthesis, Is Essential for the Formation of Inducible Membranes in Yeast.”  Mol. Biol. Cell, 13:40-51, 2002.  

262

Wang, L., Schultz, P.G. “Expanding the Genetic Code.”  Chem. Comm., 1:1-11, 2002. 

263

Anderson, J.C., Magliery, T.J., Schultz, P.G. “Exploring the Limits of Codon and Anticodon Size.”  Chemistry & Biology, 9:237-244, 2002.

264

Watanabe, C., Supekova, L., and Schultz, P.G. “The Transcriptional Effects to the Potent  Enediyne Anti-Cancer Agent Calicheamicin λ1I.”  Chemistry & Biology, 9:245-251, 2002.   

265

Ding, S., Gray, N.S., Wu, X., Ding, Q., Schultz, P.G. “A Combinatorial Scaffold approach towards Kinase-Directed Heterocycle Libraries.”  J. Am. Chem. Soc., 124(8):1594-1596, 2002.    

266

Wang, L., Brock, A., Schultz, P.G. “Adding L-3-(2-Naphthyl)alanine to the Genetic Code of E. Coli.”  J. Am. Chem. Soc., 124(9):1836-1837, 2002.  

267

Ding, S., Gray, N.S. Ding, Q., Wu, X., Schultz, P.G. “Resin-Capture and Release Strategy toward Combinatorial Libraries of 2,6,9-Substituted Purines.”  J. Comb. Chem., 4(2):183-186, 2002.   

268

Su, A.I., Cooke, M., Ching, K., Hakak, Y., Walker, J., Wiltshire, T., Orth, A.P., Vega, R., Sapinoso, L., Moqrich, A., Patapoutian, A., Hampton, G., Schultz, P.G., Hogenesch J.B. “Large-scale Analysis of the Human and Mouse Tanscriptomes.”  Pro. Nat. Acad. Sci. (USA), 99(7):4465-4470, 2002.   

269

Panda, S., Antoch, M.P., Miller, B.H., Su, A.I., Schook, A.B., Straume, M., Schultz, P.G., Kay, S.A., Takahashi, J.S., Hogenesch, J.B. “Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock.”  Cell, 109:307-320, 2002.  

270

Xia, G., Chen, L., Sera, T., Fa, M., Schultz, P.G., Romesberg, F.E. “Directed evolution of novel polymerase activities: Mutation of a DNA polymerase into an efficient RNA polymerase.”  Pro. Nat. Acad. Sci. (USA), 99(10):6597-6602, 2002.  

271

Santarsiero, B.D., Yegian, D.T., Lee, C.C., Spraggon, G., Gu, J., Scheibe, D., Uber, D.C., Cornell, E.W., Nordmeyer, R.A., Kolbe, W.F., Jin, J., Jones, A.L., Jaklevic, J.M., Schultz, P.G., and Stevens, R.C. “An Approach to Rapid Protein Crystallization Using Nanodroplets.”  J. Applied Crystallography, 35:278-281, 2002.

272

Damoiseaux, R., Schultz, P.G., Johnsson, K. “Towards the Generation of Artificial O6-Alkylguanine-DNA Alkyltransferases: in vitro Selection of Antibodies with Reactive Cysteine Residues.”  Chem Bio Chem 6:573-575, 2002.   

273

Santoro, S.W., Schultz, P.G. “Directed evolution of the site specificity of Cre recombinase.”  Proc. Natl. Acad. Sci. (USA), 99(7):4185-4190, 2002.   

274

Gildersleeve, J., Janes, J., Ulrich, H., Yang, P., Barbars, G., Schultz, P.G. “Development of a Genetic Selection for Catalytic Antibodies.”  Bioorg. Med. Chem. Lett., 12:1691-1694, 2002.    

275

Perez, O.D., Chang, Y.T., Rosania, G, Sutherlin, D, Schultz, P.G. “Inhibition and Reversal of Myogenic Differentiation by Purine-Based Microtubule Assembly Inhibitors.”  Chem. Biol. 9:475-483, 2002.  

276

Chang, Y.T., Choi, J., Ding, S., Prieschl, E.E., Baumruker, T., Lee, J.M., Chung, S.K., Schultz, P.G. “The Synthesis and Biological Characterization of a Ceramide Library.”  J. Am. Chem. Soc., 124(9):1856-1857, 2002. 

277

Supekova, L., Pezacki, J.P., Su, A., Loweth, C., Reidl, R., Geierstanger, B., Massari, E., Murre, C., Schultz, P.G., Wemmer, D. “Genomic Effects of Polyamide/DNA Interactions on mRNA Expression.”  Chem. & Biol., 9:821-827, 2002.

278

Chin, J.W., Martin, A.B., King, D.S., Wang, L., Schultz, P.G. “Addition of a Photocrosslinking Amino Acid to the Genetic Code of Escherichia coli.”  Proc. Natl. Acad. Sci. (USA), 10:11020-11024, 2002.  

279

Schultz, P.G., Lerner, R.A. “Completing the Circle.”  Nature Concepts, 418:485, 2002.     

280

Li, S., Liao, J., Cutler, G., Hoey, T., Hogenesch, J.B., Cooke, M.P., Schultz, P.G., Ling, X.B. “Comparative Analysis of Human Genome Assemblies Reveals Genome-Level Differences.”  Genomics, 80(2):138-139, 2002.  

281

Zhang, Z., Wang, L., Brock, A., Schultz, P.G. “The Selective Incorporation of Alkenes into Proteins in Escherichia coli.”  Angew. Chem., 41(15):2840-2842, 2002.  

282

Chang, Y.T., Choi, G., Bae, Y.S., Burdett, M., Moon H.S., Lee, J.W., Gray, N.S., Schultz, P.G., Meijer, L., Chung, S.K., Choi, K.Y., Suh, P.G., Ryu, S.H. “Purine-Based Inhibitors of Inositol-1,4,5-trisphosphate-3-kinase." ChemBioChem, 9:897-901, 2002.  

283

Su, A., Guidotti, L.G., Pezacki, J.P., Chisari, F.V., Schultz, P.G. “Gene Expression During the Priming Phase of Liver Regeneration after Partial Hepatectomy in Mice.”  Proc. Natl. Acad. Sci. (USA), 99(17):11181-11186, 2002.

284

Winssinger, N., Ficarro, S., Schultz, P.G., Harris, J.L. “Profiling protein function with small molecule microarrays.”  Proc. Natl. Acad. Sci. (USA), 99(17)11139-11144, 2002.  

285

Santoro, S.W., Wang, L., Herberich, B., King, D.S., Schultz, P.G. “An Efficient System for the  Evolution of Aminoacyl-tRNA Synthetase Specificity.”  Nat. Biotech., 20:1044-1048, 2002.    

286

Chin, J., Santoro, S.W., A.B., King, D.S., Wang, L., Schultz, P.G. “Addition of p-azido-L-phenylalanine to the Genetic Code of Escherichia coli.”  J. Am. Chem. Soc., 124(31):9026-9027, 2002.  

287

Yu, C., Henry, A.A., Schultz, P.G., Romesberg, F.E. “Polymerase Recognition of Unnatural Base Pairs.”  Angew.  Chem., 41(20):3841-3844, 2002.  

288

Knockaert, M., Lenormand, P., Gray, N., Schultz, P.G., Pouyssegur, J., Meijer, L. “p42/p44 MAPs are intracellular targets of the CDK inhibitor purvalanol.”  Oncogene, 21:6413-6424, 2002. 

289

Su, A.I., Pezacki, J.P., Wodicka, L., Brideau, A.D., Supekova, L., Thimme, R., Wieland, S., Bukh, J., Purcell, R.H., Schultz, P.G., Chisari, F.V. “Genomic Analysis of the Host Response to Hepatitis C Virus Infection.”  Proc. Natl. Acad. Sci. (USA), 99(24):15669-15674, 2002. 

290

Chin, J.W., Schultz, P.G. “In vivo Photocrosslinking with Unnatural Amino Acid Mutagenesis.”  ChemBioChem, 11:1135-1137, 2002.

291

Wu, X., Ding, S., Ding, Q., Gray, N.S., Schultz, P.G. “A Small Molecule with Osteogenesis-Inducing Activity in Multipotent Mesenchymal Progenitor Cells.”  J. Amer. Chem. Soc., 124(49):14520-14521, 2002.  

292

Wu, T.Y.H., Schultz, P.G. “A Versatile Linkage Strategy for Solid-Phase Synthesis of N,N-Dimethyltryptamines and Beta-Carbolines.”  Organic Letters, 4(23):4033-4036, 2002.  

293

Zimmermann, N., Meggers, E., Schultz, P.G. “A Novel Silver (I)-Mediated DNA Base Pair.”  J. Amer. Chem. Soc., 124(46); 13684-13685, 2002.   

294

Lesley, S., Kuhn, P., Godzik, A., Schultz, P.G., Wilson, I.A., Stevens, R. “Structural genomics of the Thermotoga maritime proteome implemented in a high-throughput structure determination pipeline.”  Proc. Natl. Acad. Sci. (USA), 99(18):11664-11669, 2002.

295

Schultz, P.G., Yin, J., Lerner, R.A. “The Chemistry of the Antibody Molecule.”  Angew. Chem., 41(23):4427-4437, 2002.

296

Chapman, E., Ding, S., Schultz, P.G., Wong, C. “A Potent and Highly Selective Sulfontransferase Inhibitor.”  J. Amer. Chem. Soc., 124(49):14524-14525, 2002.  

297

Wang, L., Zhang, Z., Brock, A., Schultz, P.G. “Addition of the Keto Functional Group to the Genetic Code of Escherichia coli.”  Proc. Natl. Acad. Sci. (USA), 100(1):56-61, 2003.  

298

Lin, Q., Barbas, C.F., Schultz, P.G. “Small-Molecule Switches for Zinc Finger Transcription.”  J. Amer. Chem. Soc., 125(3):612-613, 2003.

299

Mehl, R., Anderson, J.C., Santoro, S., Wang, L., Martin, A., King, D.S., Horn, D.M., Schultz, P.G. “Generation of a Bacterium with a 21 Amino Acid Genetic Code.”  J. Am. Chem. Soc., 125:935-939, 2003.

300

Wang, L., Xie, J., Deniz, A.A., Schultz, P.G. “Unnatural Amino Acid Mutagenesis of Green Fluorescent Protein.”  J. Org. Chem., 68(1):174-176, 2003.  

301

Wieland, S.F., Vega, R.G., Muller, R., Evans, C., Hilbush, B., Guidotti, L.G., Sutcliffe, J.G., Schultz, P.G., Chisari, F.V. “Searching for Interferon-Induced Genes that Inhibit Hepatitis B Virus Replication in Transgenic Mouse Hepatocytes.”  J. Virol., 77(2):1227-1236, 2003.

302

Santoro, S.W., Schultz, P.G. “Directed Evolution of the Substrate Specificities of a Site-Specific  Recombinase and an Aminoacyl-tRNA Synthetase Using Fluorescence Activated Cell Sorting.”   in Methods in Molecular Biology, Directed Enzyme Evolution: Screening and Selections  Methods, (eds., F. H. Arnold and G. Georgiou ) Humana Press Inc., Totowa, NJ, vol. 230, pp, 291-312, 2003.   

303

Licht, S.S., Sonnleitner, A., Weiss, S., Schultz, P.G. “A Rugged Energy Landscape Mechanism for Trapping of Transmembrane Receptors During Endocytosis.”  Biochemistry, 42(10):2916-2925, 2003. 

304

Liu, H., Wang, L., Brock, A., Wong, C-H., Schultz, P.G. “A Method for the Generation of Glycoprotein Mimetics.”  J. Amer. Chem. Soc., 125(7):1702-1703, 2003.

305

Salomon, A.R., Ficarro, S.B., Brill, L.M., Brinker, A., Phung, Q.T., Ericson, C., Sauer, K., Brock, A., Horn, D.M., Schultz, P.G., Peters, E.C. “Profiling of Tyrosine Phosphorylation Pathways in Human Cells Using Mass Spectrometry.”  Proc. Natl. Acad. Sci. (USA), 100(2):443-448, 2003.    

306

Yin, J., Andryski, S., Beuscher, A., Stevens, R.C., Schultz, P.G. “Structural Evidence for Substrate Strain in Antibody Catalysis.”  Proc. Natl. Acad. Sci. (USA), 100(3)856:861, 2003.

307

Zhang, Z., Smith, B., Wang, L., Brock, A., Cho, C., Schultz, P.G. “A New Strategy for the Site-Specific Modification of Proteins in vivo.”  Biochem. 42(22):6735-6746, 2003.    

308

Magliery, T.J., Pastrnak, M., Anderson, J.C., Santoro, S.W., Herberich, B., Meggers, E., Wang, L., Schultz, P.G. “In vitro Tools and in vivo Engineering: Incorporation of Unnatural Amino Acids into Proteins”  in Translation Mechanisms; Lapointe, Jacques; Brakier-Gingras, Léa, Eds,; Landes Bioscience/Eurekah.com: Georgetown, TX and Kluwer Academic/Plenum: New York, NY, 2003; pp. 95-114.  

309

Ding, S., Wu, T.Y.H., Brinker, A., Peters, E.C., Hur, W., Gray, N.S., Schultz, P.G. “Synthetic Small Molecules that Control Stem Cell Fate.”  Proc. Natl. Acad. Sci. (USA), 100(13):7632-7637, 2003.  

310

Yin, J., Beuscher, A., Andryski, S., Stevens, R.C., Schultz, P.G. “Structural Plasticity and the Evolution of Antibody Affinity and Specificity.”  J. Mol. Biol., 330:651-656, 2003.  

311

Matsuda, S., Henry, A.A., Schultz, P.G., Romesberg, F.E. “The Effect of Minor Groove  Hydrogen-Bond Acceptors and Donors on the Stability and Replication of Four Unnatural Base  Pairs.”  J. Amer. Chem. Soc., 125(20); 6134-6139., 2003.

312

Chin, J.W., Cropp, T.A., Chu, S., Meggers, E., Schultz, P.G. “Progress Toward an Expanded Eukaryotic Genetic Code.”  Chem. Biol., 10:511–519, 2003. 

313

Chin, J.W., Cropp, T.A., Anderson, J.C., Mukherji, M., Zhang, Z., Schultz, P.G. “An Expanded Eukaryotic Genetic Code.”  Science, 301:964-967, 2003.   

314

Liao, J., Schultz, P.G. “Three Sweet Receptor Genes Are Clustered in Human Chromosome 1.”  Mamm. Genome, 14(5):291-301, 2003.

315

Anderson, J.C., Schultz, P.G. “Adaptation of an Orthogonal Archaeal Leucyl-tRNA and  Synthetase Pair for Four-base, Amber, and Opal Suppression.”  Biochem., 42(32); 9598-9608, 2003.

316

Wu, T.Y.H., Schultz, P.G., Ding, S. "One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines." Org Lett., 5(20):3587-90, 2003.

317

Deiters, A., Cropp, T.A., Mukherji, M., Chin, J.W., Anderson, C., Schultz, P.G. “Adding Amino Acids with Novel Reactivity to the Genetic Code of Saccharomyces Cerevisiae.”  J. Amer. Chem. Soc., 125(39):11782 – 11783, 2003.  

318

Santoro, S., Anderson, J.C., Lakshman, V., Schultz, P.G. “An Archaebacteria-derived Glutamyl- tRNA Synthetase and tRNA Pair for Unnatural Amino Acid Mutagenesis of Proteins in Escherichia Coli.”  Nuc. Acids Res., 31(23):6700-6709, 2003.  

319

Chanda, S. K., White, S., Orth, A., Reisdorph, R., Miraglia, L., Thomas, R., DeJesus, P., Mason, D. E., Huang, Q., Vega, R., Yu, D., Nelson, C., Smith, B. M., Terry, R., Linford, A.S., Yu, Y., Chirn, G., Song, C., Labow, M.A., Cohen, D., King, F., Peters, E., Schultz, P.G., Vogt, P.K., Hogenesch, J., and Caldwell, J.S. “Genome-scale Functional Profiling of the Mammalian AP-1 Signaling Pathway.”  Proc. Natl. Acad. Sci. (USA), 100(21):12153-12158, 2003. 

320

Baldwin, E.P., Martin, S.S., Abel, J., Gelato, K.A., Kim, H., Schultz, P.G., Santoro, S.W. “A Specificity Switch in Selected Cre Recombinase Variants is Mediated by Macromolecular Plasticity and Water.”  Chem & Biol., 10(11):1085-1094, 2003.

321

Alfonta, L, Zhang, Z., Uryu, S., Loo, J.A., Schultz, P.G. “Site-Specific Incorporation of a Redox  Active Amino Acid into Proteins.”  J. Am. Chem. Soc., 125:14662-14663, 2003.  

322

Gildersleeve, J., Varvak, A., Atwell, S., Evans, D. Schultz, P.G. “Development of a High-Throughput Screen for Protein Catalysts: Application to the Directed Evolution of Antibody Aldolases.”  Angew. Chem., 42(48):5971-5973, 2003.  

323

Wu, T.Y.H., Hassig, C., Wu, Y., Ding, S., Schultz, P.G. “Design, Synthesis, and Activity of HDAC Inhibitors with an N-formyl Hydroxylamine Head Group.”  Bio. Med. Chem. Letters, 14(2):449-453, 2003.  

324

Mirotsou, M., Watanabe, C., Schultz, P.G., Pratt, R.E., Dzau, V.J. “Elucidating the Molecular Mechanism of Cardiac Remodeling Using a Comparative Genomic Approach.”  Physio. Genomics, 15: 115-126, 2003.  

325

Esaki, M., Kanamori, T., Nishikawa, S., Shin, I., Schultz, P.G., Endo, T. “Tom40 Protein Import Channel Binds to Non-Native Proteins and Prevents their Aggregation”  Nature Struct. Biol., 10(12):998-994, 2003.

326

Li, S., Cutler, G., Liu, J.J., Hoey, T., Chen, L., Schultz, P.G., Liao, J., Ling, X.B. “A comparative analysis of HGSC and Celera human genome assemblies and gene sets.”  Bioinformatics, 19(13):1597-1605, 2003.

327

Zimmermann, N., Meggers, E., Schultz, P.G. “A Second-Generation Copper (II)-Mediated Metallo-DNA-Base Pair.”  Bioorg. Chem., 32(1):13-25, 2004.  

328

Zhang, Z., Gildersleeve, J., Yang Y.Y., Xu, R., Loo, J.A., Uryu, S., Wong, C.H., Schultz, P.G. “A New Strategy for the Synthesis of Glycoproteins.”  Science, 303(16):371- 373, 2004.   

329

Chen, S., Zhang, Q, Wu, X., Schultz, P.G., Ding, S. “Dedifferentiation of Lineage-Committed Cells by a Small Molecule.”  J. Amer. Chem. Soc., 126(2):410-411, 2004.  

330

Wu, X., Ding, S., Ding, Q., Gray, N.S., Schultz, P.G. “Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells.”  J. Amer. Chem. Soc., 126:1590-1591, 2004.  

331

Yin, J., Mills, J.H., Schultz, P.G. “A Catalysis-based Selection for Peroxidase Antibodies with Increased Activity.”  J. Amer. Chem. Soc., 126(10):3006-7, 2004.

332

Huang, Q, Raya, A., Dejesus, P., Chao, S.H., Quon, K.C., Caldwell, J.S., Chanda, S.K., Izpisua-Belmonte, J.C., Schultz, P.G. “Identification of p53 Regulators by Genome-wide  Functional Analysis.”  Proc. Natl. Acad. Sci. (USA), 101(10):3456-3461, 2004.

333

Williams, B., Watanabe, C.M.H., Schultz, P.G., Rimbach, G., Krucker, T. “Age-related effects of Ginko biloba extract on synaptic plasticity and excitability.”  Neurobiology of Aging, 25 (7): 955-962, 2004.  

334

Wignall, S.M., Gray, N.S., Chang, Y.T. Juarez, L., Jacob, R., Burlingame, A., Schultz, P.G., Heald, R. “Identification of a novel protein regulating microtubule stability through a chemical approach.”  Chem. & Biol.,11(1):135-46, 2004.

335

Torres, F.E., Kuhn, P., De Bruyker, D., Bell, A.G., Wolkin, M.V., Peeters, E., Williamson, J.R., Anderson, G.B., Schmitz, G.P., Recht, M.I., Schweizer, S., Scott, L.G., Ho, J.H., Elrod, S.A., Schultz, P.G., Lerner, R.A., Bruce, R.H. “Enthalpy Arrays.”  Proc. Natl. Acad. Sci. USA, 101(26):9517-9622, 2004.  

336

Ding, S., Schultz, P.G. “A Role for Chemistry in Stem Cell Biology.”  Nat. Biotech., 22(7):833-840, 2004.  

337

Zhang, Z., Alfonta, L., Tian, F., Bursulaya, B., Uryu, S., King, D.S., Schultz, P.G. “Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells.”  Proc. Natl. Acad. Sci.(USA), 101(24):8882-8887, 2004.  

338

Zheng, L., Liu, J., Batalov, S., Zhou, D., Orth, A., Ding, S., Schultz, P.G. “An Approach to Genomewide Screens of Expressed Small Interfering RNAs in Mammalian Cells.”  Proc. Natl. Acad. Sci. (USA), 101(1): 135-140, 2004.   

339

Anderson, J.C., Wu, N., Santoro, S.W., Lakshman, V., King, D.S., Schultz, P.G. “An Expanded Genetic Code with a Functional Quadruplet Codon.”  Proc. Natl. Acad. Sci. (USA), 101(20): 7566-7571, 2004.  

340

Wu, T., Wagner, K.W., Bursulaya, B., Schultz, P.G., Deveraux, Q.L. “Development and Characterization of Non-Peptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interactions.”  Chem & Biol., 10(8):759-67, 2004.

341

Wu, X., Walker, J., Zhang, J., Ding, S., Schultz, P.G. “Purmorphamine Induces Osteogenesis by  Activation of the Hedgehog Signaling Pathway.”  Chem. & Bio., 11(9):1229-38, 2004.

342

Xie, J., Wang, L., Wu, N., Brock, A., Spraggon, G., Schultz, P.G. “The Site-specific Incorporation of p-Iodo-L-phenylalanine into Proteins for Structure Determination.”  Nat. Biotech. 22(10):1297-301, 2004. 

343

Cropp, T.A., Schultz, P.G. “An Expanding Genetic Code.”  Trends in Genetics, 20(12): 625-630, 2004.  

344

Schlieker, C., Weibezahn, J., Patzelt, H., Tessarz, P., Strub, C., Zeth, K., Erbse, A., Schneider-Mergener, J., Chin, J.W., Schultz, P.G., Bukau, B., Mogk, A. “Substrate Recognition by the AAA+ Chaperone ClpB.”  Nat. Struct. Mol. Biol., 11(7):607-15, 2004.

345

Wu, N., Deiters, A., Cropp, T.A., Schultz, P.G. “A Genetically Encoded Photocaged Amino Acid.”  J. Am. Chem. Soc., 126 (44):14306-7, 2004. 

346

Wang, L, Schultz, P.G. “Expanding the Genetic Code.”  Angew. Chem., 44(1):34-66, 2004. 

347

Tian, F., Tsao, M.L., Schultz, P.G. “A Phage Display System With Unnatural Amino Acids.”  J. Am. Chem. Soc., 126(49):15962-3, 2004. 

348

Deiters, A., Cropp, T.A., Summerer, D., Mukherji, M., Schultz, P.G. “Site-Specific PEGylation of Proteins Containing Unnatural Amino Acids.”  Bioorg. & Med. Chem. Lett., 14(23):5743-5, 2004.

349

Venkateshrao, S., Yin, J., Jarzecki, A., Schultz, P.G., Spiro, T.G. “Porphyrin Distortion During  Affinity-Maturation of a Ferrochelatase Antibody, Monitored by Resonance Raman  Spectroscopy.”  J. Amer. Chem. Soc., 126(50):16361-7, 2004. 

350

Xu, R., Hanson, S.R., Zhang, Z., Yang, Y., Schultz, P.G., Wong, C. “Site-Specific Incorporation of the Mucin-type N-Acetylgalactosamine-α-O-Threonine into Protein in Escherichia coli.”  J. Am. Chem. Soc., 126(48):15654-5, 2004.

351

Yin, J., Schultz, P.G. "Immunological evolution of antibody catalysis." In "Catalytic Antibodies" (Keinan, E. ed), Wiley-VCH, Weinheim, pp. 1-29 (2004).

352

Deiters, A., Geierstanger, B.H., Schultz, P.G. “Site-Specific In Vivo Labeling of Proteins for NMR Studies.”  ChemBioChem, 6(1):55-8, 2005.

353

Luesch, H., Wu, T.Y.H., Ren, P., Gray, N.S., Schultz, P.G., Supek, F. “A Genome-Wide Overexpression Screen in Yeast for Small Molecule Target Identification.”  Chem. & Biol., 12(1):55-63, 2005. 

354

Liu, J., Bang, A., Kintner, C., Orth, T., Chanda, S., Ding, S., Schultz, P.G. “Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genomewide functional analysis.”  Proc. Natl. Acad. Sci., 102(6):1927-32, 2005.

355

Liu, J., Wu, X., Mitchell, B., Kintner, C., Ding, S., Schultz, P.G. “A Small-Molecule Agonist of  the Wnt Signaling Pathway.”  Angew. Chem., 44(13):1987-1990, 2005.

356

Deiters, A., Schultz, P.G. “In Vivo Incorporation of an Alkyne into Proteins in Escherichia coli.”  Bioorg. Med. Chem. Lett., 15(5):1521-4, 2005. 

357

Ding, S., Schultz, P.G. “Small molecules and Future Regenerative Medicine.”  Current Topics in Medicinal Chemistry, 5(4): 383-394, 2005.

358

Zhang, Y., Wang, L., Schultz, P.G., Wilson, I.A. “Crystal Structures of apo Wild-Type M. jannaschii TyrRS and a Mutant Synthetase Specific for O-Methyl-L-Tyrosine.”  Protein Science, 14(5):1340-9, 2005.

359

Xie, J., Schultz, P.G. “An Expanding Genetic Code.”  Methods, 36(3):227-38, 2005. 

360

Willingham, A.T., Orth, A.P., Batalov, S., Peters, E.C., Wen, B.G., Aza-Blanc, P., Hogenesch, J.B., Schultz, P.G. “A Strategy for Determining the Function of Noncoding RNAs Identifies a Repressor of NFAT.”  Science, 309(5740): 1570-3, 2005. 

361

Turner, J.M., Graziano, J., Spraggon, G., Schultz, P.G. “Structural Characterization of a p-Acetylphenylalanyl Aminoacyl-tRNA Synthetase.”  J. Am. Chem. Soc., 127(43): 14976-14977, 2005.

362

Xie, J., Schultz, P.G. “Adding Amino Acids to the Genetic Repertoire.”  Curr. Opin Chem Biol., 9:548-554, 2005.

363

Tsao, M., Tian, F., Schultz, P.G. “Selective Staudinger Modification of Proteins Containing p-Azidophenylalanine.”  ChemBioChem. 6(12): 2147-2149, 2005.

364

Warashina, M., Min, K.H., Kuwabara, T., Huynh, A., Gage, F.H., Schultz, P.G., Ding, S. “A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells.”  Angew. Chem., 45(4):591-593, 2005.

365

Bose, M., Groff, D., Xie, J., Brustad, E., Schultz, P.G. “The Incorporation of a Photoisomerizable Amino Acid into Proteins in E. coli.” J. Am. Chem. Soc., 128(2):388-9, 2006.

366

Lowery, T.J., Garcia, S., Chavez, L., Ruiz, E.J., Wu, T., Brotin, T., Dutasta, J.P., King, D.S., Schultz, P.G., Pines, A., Wemmer, D.E. "Optimization of xenon biosensors for detection of protein interactions." Chembiochem, 7(1):65-73, 2006.

367

Sagan, S.M., Rouleau, Y., Leggiadro, C., Supekova, L., Schultz, P.G., Su, A.I., Pezacki, J.P. “The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.” Biochem. Cell Biol., 84:67-79, 2006.

368

Luesch, H., Chanda, S.K., Raya, R. M., Orth, A.P., Walker, J.R., Izpisúa Belmonte, J.C., Schultz, P.G., “A Functional Genomics Approach to the Mode of Action of the Antiproliferative Natural Product Apratoxin A,” Nat. Chem. Bio., 2(3):158-167, 2006.

369

Melnick, J.S., Janes, J., Kim, S., Chang, J.Y., Sipes, D.G., Gunderson, A., Jarnes, L., Matzen, J.T., Garcia, M.E., Hood, T.L., Beigi, R., Xia, G., Harig, R.A., Asatryan, H., Yan, S.F., Zhou, Y., Gu, X-J., Saadat, A., Zhou, V., King, F.J., Shaw, C.M., Su, A.I., Downs, R., Gray, N.S., Schultz, P.G., Warmuth, M., Caldwell, J.S. “An Efficient Rapid System for Profiling the Cellular Activities of Molecular Libraries.” Proc. Natl. Acad. Sci., 103(9):3153–3158, 2006.

370

Ryu, Y., Schultz, P.G. “Efficient incorporation of unnatural amino acids into proteins in Escherichia coli.”  Nature Methods, 3(4):263-5, 2006.

371

Deiters, A., Groff, D., Ryu, Y., Xie, J., Schultz, P.G. “A Genetically Encoded Photocaged Tyrosine.”  Angew. Chemie, 45(17):2728-2731, 2006. 

372

Turner, J.M., Graziano, J., Spraggon, G., Schultz, P.G. “Structural plasticity of an aminoacyl-tRNA synthetase active site.”  Proc. Natl. Acad. Sci., 103(17):6483-8, 2006. 

373

Berezhna, S.Y., Supekova, L., Supek, F., Schultz, P.G., Deniz, A.A. “siRNA in human cells selectively localizes to target RNA sites.”  Proc. Natl. Acad. Sci., 103(20):7682–7687, 2006.

374

Tsao, M.L., Summerer, D., Ryu, Y., Schultz, P.G. “The genetic incorporation of a distance probe into proteins in Escherichia coli.”  J. Am. Chem. Soc., 128(14):4572-3, 2006. 

375

Summerer, D., Chen, S., Wu, N., Deiters, A., Chin, J., Schultz, P.G. “A Genetically Encoded Fluorescent Amino Acid.”  Proc. Natl. Acad. Sci. (USA), 103(26):9785–9789, 2006.

376

Cho, C.Y., Koo, S-H., Wang, Y., Callaway, S., Hedrick, S., Mak, P.A., Orth, A.P., Peters, E.C., Saez, E., Montminy, M., Schultz, P.G., Chanda, S.K., “Identification of the Tyrosine Phosphatase PTP-MEG2 as an Antagonist of Hepatic Insulin Signaling.” Cell Metab., 3(5):367-78, 2006.

377

Wang, L., Xie, J., Schultz, P.G. “Expanding the Genetic Code.”  Ann. Rev. Biophys. Biomol. Struct., 9(35):225-249, 2006.

378

Wang, J., Xie, J., Schultz, P.G. “A Genetically Encoded Fluorescent Amino Acid.” J. Am. Chem. Soc., 128(27):8738-9, 2006.

379

Collins, C., Hong, J., Sapinoso, L., Zhou, Y., Liu, Z., Micklash, K., Schultz, P.G., Hampton, G.M.  “A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.”  Proc. Natl. Acad. Sci., 103(10):3775-80, 2006.

380

Zeng, H., Xie, J., Schultz, P.G. “Genetic introduction of a diketone-containing amino acid into proteins.”  Bioorg Med Chem Lett., 16: 5356–5359, 2006.  

381

Xie, J., Schultz, P.G. “A chemical toolkit for proteins – an expanded genetic code.” Nat. Rev. Mol. Cell Biol., 7(10):775-82, 2006. 

382

Schultz, K.C., Supekova, L., Ryu, Y., Xie, J., Perera, R., Schultz, P.G. “A Genetically Encoded Infrared Probe.” J. Am. Chem. Soc., 128(43):13984-5, 2006. 

383

Mukherji, M., Cho, C., Supekova, L., Wang, Y., Batalov, S., Bell, R., Martin, C., Sahasrabuhde,  S., Orth, A.P., Chanda, S.K., Schultz, P.G. “Genome-wide Functional Analysis of Human Cell-cycle Regulators..” Proc. Natl. Acad. Sci. (USA), 103 (40): 14819-14824, 2006.  

384

Chen, S., Do, J., Zhang, Q., Yao, S., Yan, F., Peters, E., Scholer, H., Schultz, P.G., Ding, S. “Self-renewal of Embryonic Stem Cells by a Small Molecule.” Proc. Natl. Acad. Sci., 103(46):17266-17271, 2006.  

385

Liu, C., Schultz, P.G. “Recombinant expression of selectively sulfated proteins in E. coli.”  Nat. Biotechnol., 24(11):1436-40, 2006. 

386

Tian, F., Debler, E.W., Millar, D.P., Deniz, A.A., Wilson, I.A., Schultz, P.G. “Multilcolor Fluorescent Antibodies.”  Angew. Chem., 45(46):7763-7765, 2006.

387

Saraf-Levy, T., Santoro, S.W., Volpin, H., Kushnirsky, T., Eyal, Y., Schultz, P.G., Gidoni, D., Carmi, N. “Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex.” Bioorg. Med. Chem., 14(9):3081-9, 2006.

388

Mukherji, M., Brill, L.M., Ficarro, S.B., Hampton, G.M., Schultz, P.G. “A Phosphoproteomic Analysis of the ErbB2 Receptor Tyrosine Kinase Signaling Pathways.” Biochemistry, 45(51):15529-15540, 2006.

389

Galkin, A., Melnick, J., Kim, S., Hood, T., Li, N., Li, L., Xia, G., Steensma, R., Chopiuk, G., Jiang, J., Wan, Y., Ding, P. Zun, F., Schultz, P.G., Gray, N.S., Warmuth, M. “Identification of NVP-TAE684: A potent, selective and efficacious inhibitor of NPM-ALK.” Proc. Natl. Acad. Sci. (USA), 104(1) 270-275, 2007.

390

Macpherson, L.J., Dubin, A.E., Evans, M.J., Marr, F., Schultz, P.G., Cravatt, B.F., Patapoutian, A.  “Noxious compounds activate TRPA1 ion channel via covalent modification of cysteines.” Nature, 445(7127):541-5, 2007.

391

Liu, W., Brock, A., Chen, S., Chen, S., Schultz, P.G. “The Genetic Incorporation of Unnatural Amino Acids into Proteins in Mammalian Cells.”  Nat. Methods, 4: 239-244, 2007.

392

Liu, Y., Kern, J.T., Johnson, J., Schultz, P.G., Luesch, H. “A genomic screen for activators of the antioxidant response element.”  Proc. Natl. Acad. Sci, 104(12): 5205-5210, 2007. 

393

Hong, J., Lee, J., Min, K-H., Walker, J.R., Gray, N.S., Cho, C.Y., Schultz, P.G. “Identification and characterization of small molecule inducers of epidermal keratinocyte differentiation.” ACS Chem. Biol., 2(3): 171-175, 2007.

394

Gumireddy, K., Sun, F., Klein-Szanto, A.,J., Gibbins, J.M., Saunders, A., Schultz, P.G., Huang, Q. “In vivo Selection for Metastasis Promoting Genes in the Mouse.”  Proc. Natl. Acad. Sci., 104(16):6696-701, 2007.

395

Zhang, Q., Major, M., Takanashi, S., Camp, N., Nishiya, N., Ginsberg, M., Schultz, P.G., Moon, R.T., Ding, S.  “A Small Molecule Synergist of the Wnt/β-catenin Signaling Pathway.” Proc. Natl. Acad. Sci, 104(18): 7444-7448, 2007.

396

Tippmann, E., Schultz, P.G.  “A Genetically Encoded Metallocene Containing Amino Acid.” Tetrahedron, 63: 6182–6184, 2007.

397

Chen, S., Schultz, P.G., Brock, A. "An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae." J. Mol. Biol., 371: 112–122, 2007.

398

Chen, S., Takanashi, S., Zhang, Q., Xiong, W., Zhu, S., Peters, E.C., Ding, S., Schultz, P.G. “Reversine Increases the Plasticity of Lineage-Committed Mammalian Cells.”  Proc. Natl. Acad. Sci. (USA), 104(25):10482-7, 2007.

399

Liu, W., Alfonta, L., Mack, A.V., Schultz, P.G. "Structural Basis for the Recognition of p-Benzoyl-L-phenylalanine by Evolved Aminoacyl-tRNA Synthetases." Angew. Chem., 46(32):6073-6075, 2007.

400

Xie, J., Supekova, L., Schultz, P.G. “A Genetically Encoded Metabolically Stable Analogue of Phosphotyrosine in E. coli.”  ACS Chem. Biol.,2(7):474-8, 2007.

401

Dierks, C., Grbic, J., Zirlik, K., Beigi, R., Englund, N.P., Guo, G-R., Veelken, H., Engelhardt, M., Mertelsmann, R., Kelleher, J.F., Schultz, P.G., Warmuth, M. "Essential role of stroma-induced hedgehog signaling in B-cell malignancies." Nat. Methods,13(8):944-951, 2007.

402

Trisler, K., Looger, L.L., Sharma, V., Baker, M., Benson, D.E., Trauger, S., Schultz, P.G., Smider, V.V. "A Metalloantibody That Irreversibly Binds a Protein Antigen." J. Biol. Chem., 282(36):26344-53, 2007.

403

Wang, J., Schiller, S., Schultz, P.G. "A Biosynthetic Route to Dehydroalanine Containing Proteins." Angew. Chem., 46(36):6849-6851, 2007.

404

Matsuda, S., Fillo, J.D., Henry, A.A., Rai, P., Wilkens, S.J., Dwyer, T.J., Geierstanger, B.H., Wemmer, D.E., Schultz, P.G., Spraggon, G., Romesberg, F.E. "Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs." J. Amer. Chem. Soc., 129(34):10466-10473, 2007.

405

Liu, C.C., Brustad, E., Liu, W., Schultz, P.G. "Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin." J. Amer. Chem. Soc., 129(35):10648-9, 2007.

406

Lyssiotis, C.A., Walker, J.R., Wu, C., Kondo, T., Schultz, P.G., Wu, X. "Inhibition of Histone Deacetylase Activity Induces Developmental Plasticity in Oligodendrocyte Precursor Cells." Proc. Natl. Acad. Sci., 104(38):14982-7,2007.

407

Lee, J., Wu, X., Pasca di Magliano, M., Peters, E.C., Wang, Y., Hong, J., Hebrok, M., Ding, S., Cho, C.Y., Schultz, P.G. "A Small Molecule Antagonist of the Hedgehog Signaling Pathway." ChemBioChem., 8(16):1916-1919, 2007.

408

Xie, J., Liu, W., Schultz, P.G. “A Genetically Encoded Bidentate, Metal-binding Amino Acid.”  Angew. Chem., 46(48):9239-9242, 2007.

409

Supekova, L., Supek, F., Lee, J., Chen, S., Gray, N., Pezacki, J., Schlapbach, A., Schultz, P.G., “Identification of human kinases involved in HCV replication by siRNA library screening.” J. Biol. Chem., 283(1):29-36, 2008.

410

Lemke, E.A., Summerer, D., Geierstanger, B.H., Brittain, S.M., Schultz, P.G. "Control of protein phosphorylation with a genetically encoded photocaged amino acid." Nat. Chem. Biol., 3(12):769-772, 2007.

411

Seyedsayamdost, M.R., Xie, J., Chan, C.T., Schultz, P.G., Stubbe, J. "Site-specific Insertion of 3-Aminotyrosine into Subunit α2 of E. coli Ribonucleotide Reductase: Direct Evidence for Involvement of Y730 and Y731 in Radical Propagation." J. Am. Chem. Soc., 129(48):15060-15071, 2007.

412

Tippmann, E.M., Liu, W., Summerer, D., Geierstanger, B., Mack, A.V., Schultz P.G. "A Genetically Encoded Diazirine Photocrosslinker in Escherichia coli." ChemBioChem, 8(18):2210-2214, 2007.

413

Guo, J., Wang, J., Anderson, J.C., Schultz, P.G. "Addition of an Alpha Hydroxy Acid to the Genetic Code of Bacteria." Angew. Chem., 47(4):722-725, 2007.

414

Graziano, J.J., Liu, W., Perera, R., Geierstanger, B.H., Lesley, S.A., Schultz, P.G. “Selecting folded proteins from a library of secondary structural elements.”  J. Am. Chem. Soc., 130(1):176-85, 2008.

415

Debler, E.W., Kaufmann, G.F., Meijler, M.M., Heine, A., Mee, J.M., Mukhopadhyay, S., Pljevaljcic, G., Di Bilio, A.J., Deniz, A.A., Schultz, P.G., Millar, D.P., Janda, K.D., Wilson, I.A., Gray, H.B., Lerner, R.A. "Deeply Inverted Electron-Hole Recombination Triggers Intensely Blue Luminescence in an Antibody-Stilbene Complex." Science, 319(5867):1232-5, 2008.

416

Lee, J., Hong, J., Nam, T.-G., Peters, E.C., Orth, A.P., Geierstanger, B.H., Goldfinger, L.E., Ginsberg, M.H., Cho, C.Y., Schultz, P.G. "A Small Molecule Inhibitor of α4 Integrin-Dependent Cell Migration." Bioorg. Med. Chem., in press, 2007.

417

Kato, N., Sakata, T., Breton, G., Le Roch, K.G., Nagle, A., Andersen, C., Bursulaya, B., Henson, K., Johnson, J., Kumar, K.A., Marr, F., Mason, D.,
McNamara, C., Plouffe, D., Ramachandran, V., Spooner, M., Tuntland, T., Zhou, Y., Peters, E.C., Chatterjee, A., Schultz, P.G., Ward, G.E., Gray, N., Harper, J., Winzeler, E.A. "Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility." Nat. Chem. Biol., 4(6): 347-356, 2008.

418

Cellitti, S.E., Jones, D.H., Lagpacan, L., Hao, X., Zhang, Q., Hu, H., Brittain, S.M., Brinker, A., Caldwell, J., Brock, A., Ryu, Y., Uno, T., Schultz, P.G., Geierstanger, B.H. "In vivo incorporation of unnatural amino acids to probe structure, dynamics and ligand binding in a large protein by Nuclear Magnetic Resonance spectroscopy." J. Am. Chem. Soc., 130(29):9268-81, 2008.

419

Plouffe, D., Brinker, A., McNamara, C., Henson, K., Kato, N., Kuhen, K., Nagle, A., Adrián, F., Matzen, J.T., Anderson, P., Nam, T.G., Gray, N.S., Chatterjee, A., Janes, J., Yan, S.F., Trager, R., Caldwell, J.S., Schultz, P.G., Zhou, Y., Winzeler, E.A. "In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen." Proc. Natl. Acad. Sci., 105(26):9059-64, 2008.

420

Guo, J., Wang, J., Lee, J.-S., Schultz, P.G. "Site-Specific Incorporation of Methyl- and Acetyl-Lysine Analogues into Recombinant Proteins." Angew. Chem.,47(34):6399-401, 2008.

421

Grünewald, J., Tsao, M.-L., Perera, R., Dong, L., Niessen, F., Kubitz, D.M., Smider, V.V., Ruf, W., Nasoff, M., Lerner, R.A., Schultz, P.G. "Immunochemical Termination of Self-Tolerance." Proc. Natl. Acad. Sci.,105(32):11276-80, 2008.

422

Lee, H., Schultz, P.G. "Biosynthesis of Site-specific DNA Cleaving Proteins." J. Am. Chem. Soc.,130(40):13194-5, 2008.

423

Brustad, E., Bushey, M.L., Brock, A., Chittuluru, J., Schultz, P.G. "A Promiscuous Aminoacyl-tRNA Synthetase that Incorporates Cysteine, Methionine, and Alanine Homologues into Proteins." Bioorg. Med. Chem. Let., 18(22):6004-6, 2008.

424

Brustad, E., Bushey, M.L., Lee, J.W., Groff, D., Liu, W., Schultz, P.G. "A Genetically Encoded Boronate Amino Acid." Angew. Chem., 47(43):8220-3, 2008.

425

Liu, C.C., Mack, A.V., Tsao, M-L., Mills, J.H., Lee, H., Choe, H., Farzan, M., Schultz, P.G., Smider, V.V. "Protein Evolution with an Expanded Genetic Code." Proc. Natl. Acad. Sci., 105(46):17688-93, 2008.

426

Dubrovska, A., Kim, S., Salamone, R.J., Walker, J., Maira, S-M., García-Echeverría, C., Schultz, P.G., Reddy, V.A. "The role of PTEN/Akt/PI3K signaling on the maintenance and viability of prostate cancer stem-like cell populations." Proc. Nat. Acad. Sci., 106(1):268-273, 2009.

427

Brustad, E.M., Lemke, E., Schultz, P.G., Deniz, A.A. "A General and Efficient Method for the Site-Specific Dual Labeling of Proteins for Single Molecule FRET." J. Am. Chem. Soc., 130(52):17664-5, 2008.

428

Hirota,T., Lewis, W.G., Liu, A.C., Lee, J.W., Schultz, P.G., Kay, S.A. "A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β." Proc. Nat. Acad. Sci., 105(52):20746-51, 2008.

429

Wang, W., Walker, J.R., Wang, X., Tremblay, M.S., Lee, J.W., Wu, X., Schultz, P.G. "Small molecule inducers of pancreatic β-cell expansion." Proc. Nat. Acad. Sci., 106(5):1427-32, 2009.

430

Lee, H.S., Spraggon, G., Schultz, P.G., Wang, F. "Genetic Incorporation of a Metal-ion Chelating Amino Acid into Proteins as a Biophysical Probe." J. Am. Chem. Soc.,131(7):2481-2483, 2009.

431

Wikoff, W.R., Anfora, A.T., Liu, J., Schultz, P.G., Lesley, S.A., Peters, E.C., Siuzdak, G. "Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites." Proc. Nat. Acad. Sci., in press, 2008.

432

Grünewald, J., Hunt, G.S., Dong, L., Niessen, F., Wen, B.G., Tsao, M-L., Perera, R., Kang, M., Laffitte, B.A., Azarian, S., Ruf, W., Nasoff, M., Lerner, R.A., Schultz, P.G., Smider, V.V. "Mechanistic Studies of the Immunochemical Termination of Tolerance with Unnatural Amino Acids." Proc. Nat. Acad. Sci., in press, 2008.

433

Peters, F.B., Brock, A., Wang, J., Schultz, P.G. "Photocleavage of the Protein Backbone by Genetically Encoded 2-Nitrophenylalanine." Chem. Biol., in press, 2008.

In Press

P1

Young, T.S., Ahmad, I., Brock, A., Schultz, P.G. "Expanding the Genetic Repertoire of the Methylotrophic Yeast, Pichia pastoris." Biochemistry, in press, 2008.

P2

Chen, P.R., Groff, D., Guo, J., Ou, W., Geierstanger, B., Schultz, P.G. "A Facile System for Encoding Unnatural Amino Acids in Mammalian Cells." Angew. Chem., in press, 2009.

P3

Groff, D., Thielges, M.C., Cellitti, S., Schultz, P.G., Romesberg, F.E. "Efforts Toward the Direct Experimental Characterization of Enzyme Microenvironments: Evaluation of Tyrosine100 in Dihydrofolate Reductase." Angew. Chem., in press, 2009.