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Current Publications
1985 - 1990- 1995- 2000 - 2005
1. Schultz, P.G., Dervan, P.B. “Synthesis and Direct Spectroscopic Observation of N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene. Comparison of Five- and Six-Membered Cyclic 1,1-Diazenes.” J. Am. Chem. Soc., 102:878-880, 1980.
2. Schultz, P.G., Dervan, P.B. “Photochemistry of a 1,1-Diazene: N-(2,2,5,5-Tetramethylpyrrolidyl )nitrene.” J. Am. Chem. Soc., 103:1563-1567, 1981.
3. Hinsberg, III, W.D., Schultz, P.G., Dervan, P.B. “Direct Studies of 1,1- Diazenes Syntheses, Infrared and Electronic Spectra, and Kinetics of Thermal Decomposition of N-(2,2,6,6-Tetramethylpiperdyl)nitrene and N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene.” J. Am. Chem. Soc., 104:766-773, 1982
4. Schultz, P.G., Dervan, P.B. “Photochemistry of 1,1-Diazenes. Direct and Sensitized Photolyses of N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene, d1-N-(2,5-Diethyl-2,5-dimethylpyrrolidyl)nitrene and N-(2,2,6,6-Tetramethylpiperdyl)-nitrene.” J. Am. Chem. Soc., 104:6660-6668, 1982.
5. Schultz, P.G., Taylor, J.S., Dervan, P.B. “Design and Synthesis of a Sequence Specific DNA Cleaving Molecule, Distamycin-EDTA.Fe(II).” J. Am. Chem. Soc., 104:6861-6863, 1982.
6. Schultz, P.G., Dervan, P.B. “Sequence Specific Double Strand Cleavage of DNA with Penta-N-Methylpyrrolecarboxamide-EDTA•Fe(II).” Proc. Natl. Acad. Sci., 80:6834-6837, 1983.
7. Schultz, P.G., Dervan, P.B. “Design of Sequence Specific Double Strand DNA Cleaving Molecules. Bis(EDTA-distamycin•Fe(II) and EDTA-(Bisdistamycin)•Fe(II).” J. Am. Chem. Soc., 105:7748-7750, 1983.
8. Taylor, J. S., Schultz, P. G., Dervan, P. B. “DNA Affinity Cleaving. Sequence Specific Cleavage of DNA by Distamycin-EDTA-Fe(II) and EDTA-Distamycin•Fe(II).” Tetrahedron Symposium, 40:457-465, 1984.
9. Schultz, P.G., Dervan, P.B. “Distamycin and penta-n-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving.” J. Biomol. Struc. Dyn., 1:1133-1147, 1984.
10. Schultz, P.G., Au, K.G., Walsh, C.T. “Active Site Mutations of Mercuric Reductase.” Biochemistry, 24: 6840-6837, 1985.
11. Pollack, S.J., Jacobs, J.W., Schultz, P.G. “Selective Chemical Catalysis by an Antibody.” Science, 234:1570-1573, 1986.
12. Jacobs, J.W., Schultz, P.G. “Catalytic Antibodies.” J. Am. Chem. Soc., 109: 2174-2176, 1987.
13. Zuckermann, R.N., Corey, D.R., Schultz, P.G. "Efficient Methods for Attachment of Thiol Specific Probes to the 3'-ends of Synthetic Oligodeoxyribonucleotides.” Nucleic Acids Res., 15(13):5305-5321, 1987.
14. Pollack, S.J., Schultz, P.G. "Antibody Catalysis by Transition State Stabilization." Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor, New York, 52:97-104, 1987.
15. Jacobs, J.W., Schultz, P.G. "Catalytic Antibodies: Generation and Characterization.” Molecular Structure and Energetics, J. Liebman & A. Greenberg, (eds), VCH, Florida, 9:303-335, 1988.
16. Corey, D.R., Schultz, P.G. "Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease" Science, 238:1401-1403, 1987.
17. Zuckermann, R.N., Corey, D.R., Schultz, P.G. "Site-Selective Cleavage of RNA by a Hybrid Nuclease.” J. Am. Chem. Soc., 110:1614-1615, 1988.
18. Schultz, P.G. "The Interplay between Chemistry and Biology in the Design of Enzymatic Catalysts.” Science,240:426-433, 1988.
19. Jackson, D.Y., Jacobs, J.W., Sugasawara, R., Reich, S.H., Bartlett, P.A., Schultz, P.G. "An Antibody-Catalyzed Claisen Rearrangement.” J. Am. Chem. Soc.,110: 4841-4842, 1988.
20. Shokat, K.M., Leumann, C.J., Sugasawara, R., Schultz, P.G. "An Antibody-Mediated Redox Reaction.” Angew. Chem. Int. Engl. Ed.,27:1172-1174, 1988.
21. Zuckermann, R.N., Schultz, P.G. "A Hybrid Sequence-Selective Ribonuclease S.” J. Am. Chem. Soc.,110:6592-6594, 1988.
22. Cochran, A.G., Sugasawara, R., Schultz, P.G. "Photosensitized Cleavage of a Thymine Dimer by an Antibody.” J. Am. Chem. Soc.,110:7888-7890, 1988.
23. Pollack, S.J., Nakayama, G.R., Schultz, P.G. "Introducion of Nucleophiles and Spectroscopic Probes into Antibody Combining Sites.” Science, 242:1038-1040, 1988.
24. Durfor, C.N., Bolin, R.J., Sugasawara, R.J., Massey, R.J., Jacobs, J.W., Schultz, P.G. "Antibody Catalysis in Reverse Micelles.” J. Am. Chem. Soc., 110:8713-8714, 1988.
25. Zuckermann, R.N., Schultz, P.G. "Site-Selective Cleavage of Structured RNA by a Staphylococcal Nuclease-DNA Hybrid.” Proc. Natl. Acad. Sci. (USA), 86:1766-1770, 1989.
26. Corey, D.R., Schultz, P.G. "Introduction of a Metal-dependent Regulatory Switch into an Enzyme.” J. Biol. Chem., 264(7):3666-3669, 1989.
27. Pollack, S.J., Nakayama, G.R., Schultz, P.G. "Design of Catalytic Antibodies.” Methods in Enzymology, 178:551-568, 1989.
28. Saha, A., Schultz, P.G., Rapoport, H. "1,1'-Carbonylbis(3-methylimidazolium) Triflate: An Efficient Method for Aminoacylations.” J. Am. Chem. Soc., 111:4856-4859, 1989.
29. Pollack, S.J., Schultz, P.G. "A Semisynthetic Catalytic Antibody.” J. Am. Chem. Soc., 111:1929-1931, 1989.
30. Shokat, K.M., Leumann, C., Sugasawara, R., Schultz, P.G. "A New Strategy for the Generation of Catalytic Antibodies.” Nature, 338(6212):269-271, 1989.
31. Schultz, P.G. "Catalytic Antibodies.” Accounts of Chem. Res., 22:287-294, 1989.
32. Noren, C.J., Anthony-Cahill, S.J., Griffith, M.C., Schultz, P.G. "A General Method for Site-Specific Incorporation of Unnatural Amino Acids into Proteins.” Science,244:182-188, 1989.
33. Corey, D.R., Pei, D., Schultz, P.G. "Generation of a Catalytic Sequence-Specific Hybrid DNase.” Biochemistry,28:8277-8286, 1989.
34. Pollack, S.J., Hsiun, P., Schultz, P.G. "Stereospecific Hydrolysis of Alkyl Esters by Antibodies.” J. Am. Chem. Soc., 111:5961-5962, 1989.
35. Schultz, P.G. "Catalytic Antibodies.” Angew. Chem. Int. Engl. Ed., 28(10):1283-1295, 1989.
36. Baldwin, E., Schultz, P.G. "Generation of a Catalytic Antibody by Site-Directed Mutagenesis.” Science, 245:1104-1107, 1989.
37. Anthony-Cahill, S.J., Griffith, M.C., Noren, C.J., Suich, D.J., Schultz, P.G. "Site-Specific Mutagenesis with Unnatural Amino Acids.” Trends in Biochemical Sciences, 14(10):400-403, 1989.
38. Corey, D.R., Pei, D., Schultz, P.G. "Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease.” J. Am. Chem. Soc., 111:8523-8525, 1989.
39. Robertson, S.A., Noren, C.J., Anthony-Cahill, S.J., Griffith, M.C., Schultz, P.G. "The Use of 5'-phospho-2'-deoxyribocytidylylriboadenosine as a Facile Route to Chemical Aminoacylation of tRNA.” Nucleic Acids Res., 17(23):9649-9660, 1989.
40. Noren, C.J., Anthony-Cahill, S.J., Suich, D.J., Noren, K.A., Griffith, M.C., Schultz, P.G. "In Vitro Suppression of an Amber Mutation by a Chemically Aminoacylated Transfer RNA Prepared by Runoff Transcription.” Nucleic Acids Res., 18(1):83-88, 1989.
41. Schultz, P.G., Hoyer, D., Cho, H. "A New Strategy for the Selective Cleavage of Proteins.” J. Am. Chem. Soc., 112:3249-3250, 1990.
42. Shokat, K.M., Schultz, P.G. "Catalytic Antibodies.” Ann. Rev. Immunology, 8:335-363, 1990.
43. Pei, D., Schultz, P.G. "Site-Specific Cleavage of Duplex DNA with a λ Repressor-Staphylococcal Nuclease Hybrid.” J. Am. Chem. Soc., 112:4579-4580, 1990.
44. Schultz, P.G., Lerner, R.A., Benkovic, S.J. "Catalytic Antibodies.” C&E News, 68:26-40, 1990.
45. Cochran, A., Schultz, P.G. "Antibody-Catalyzed Porphyrin Metallation.” Science, 249:781-783, 1990.
46. Braisted, A., Schultz, P.G. "An Antibody-Catalyzed Bimolecular Diels-Alder Reaction.” J. Am. Chem. Soc., 112: 7430-7431, 1990.
47. Cochran, A., Schultz, P.G. "Peroxidase Activity of an Antibody-Heme Complex.” J. Am. Chem. Soc., 112:9414-9415, 1990.
48. Shokat, K.M., Ko, M.K., Scanlan, T.S., Kochersperger, L., Yonkovich, S., Thaisrivongs, S., Schultz, P.G. "Catalytic Antibodies: A New Class of Transition State Analogues Used to Elicit Hydrolytic Antibodies.” Angew. Chem. Int. Engl. Ed., 29:1296-1303, 1990.
49. Pei, D., Corey, D.R., Schultz, P.G. "Site-Selective Cleavage of Duplex DNA by a Semisynthetic Nuclease via Triple-Helix Formation.” Proc. Natl. Acad. Sci. (USA), 87: 9858-9862, 1990.
50. Pollack, S.J., Schultz, P.G. "Semisynthetic Catalytic Antibodies.” in Protein Design and the Development of New Therapeutics and Vaccines, (eds., J. Hook and G. Poste) Plenum, New York, pp. 371-394, 1990.
51. Jackson, D., Prudent, J., Baldwin, E., Schultz, P.G. "A Mutagenesis Study of a Catalytic Antibody.” Proc. Natl. Acad. Sc. (USA), 88:58-62, 1991.
52. Shokat, K.M., Schultz, P.G. "Redirecting the Immune Response: Ligand Mediated Immunogenicity.” J. Am. Chem. Soc., 113:1861-1862, 1991.
53. Jackson, D.Y., Schultz, P.G. "An Antibody-Catalyzed Cis-Trans Isomerization.” J. Am. Chem. Soc., 113:2319-2321, 1991.
54. Robertson, S.A., Ellman, J., Schultz, P.G. "A General and Efficient Route for Chemical Aminoacylation of Transfer RNAs" J. Am. Chem. Soc., 113:2722-2729, 1991.
55. Mendel, D., Ellman, J., Schultz, P.G. "Construction of a Light-Activated Protein by Site Directed Unnatural Amino Acid Mutagenesis.” J. Am. Chem. Soc., 113:2758-2760, 1991.
56. Chmielewski, J., Schultz, P.G. "Monoclonal Antibodies with Sequence Specific Affinity for a Stem-Loop Structure in DNA.” Tetrahedron Symposium in Print, 14(15):2563-2572, 1991.
57. Lerner, R.A., Benkovic, S.J., Schultz, P.G. "At the Crossroads of Chemistry and Immunology: Catalytic Antibodies" Science, 252:659-667, 1991.
58. Scanlan, T., Schultz, P.G., "Recent Advances in Catalytic Antibodies.” Philosophical Transactions of the Royal Society, 332:157-164, 1991.
59. Nakayama, G., Schultz, P.G. "Approaches to the Design of Semisynthetic Metal Dependent Catalytic Antibodies.” Ciba Foundation Symposium, 159:72-91, 1991.
60. Shokat, K.M., Schultz, P.G. "The Generation of Antibody Combining Sites Containing Catalytic Residues.” Ciba Foundation Symposium, 159:118-134, 1991.
61. Martin, J.T., Schantz, A.R., Schultz, P.G., Rees, A.R. "Characterization of the Mechanism of Action of a Catalytic Antibody.” Ciba Foundation Symposium, 159:188-201, 1991.
62. Corey, D.R., Zuckermann, R., Schultz, P.G. "Hybrid Enzymes and the Sequence-Specific Cleavage of Nucleic Acids.” in Frontiers in Bioorganic Chemistry vol. 2, H. Dugas: Berlin, pp. 3-31, 1991.
63. Cochran, A.G., Pham, T., Sugasawara, R., Schultz, P.G. "Antibody-Catalyzed Bimolecular Imine Formation." J. Am. Chem. Soc., 113:6670-6672, 1991.
64. Pei, D., Ulrich, H., Schultz, P.G. "A Combinatorial Approach Toward DNA Recognition." Science, 25:1408-1411, 1991.
65. Martin, M.T., Napper, A.D., Schultz, P.G., Rees, A.R. "Mechanistic Studies of a Tyrosine-Dependent Catalytic Antibody." Biochemistry, 30:9757-9761, 1991.
66. Jackson, D.Y., King D., Chmielewski, J., Singh, S., Schultz, P.G. "General Approach to the Synthesis of Short a-Helical Peptides." J. Am. Chem. Soc., 113:9398-9400, 1991.
67. Scanlan, T.S., Prudent, J.R., Schultz, P.G. "Antibody-Catalyzed Hydrolysis of Phosphate Monoesters." J. Am. Chem. Soc., 113:9397-9398, 1991.
68. Pei, D., Schultz, P.G. "Engineering Protein Specificity: Gene Manipulation with Semisynthetic Nucleases." J. Am. Chem. Soc., 113:9391-9392, 1991.
69. Ellman, J., Mendel D., Anthony-Cahill, S., Noren, C.J., Schultz, P.G. "Biosynthetic Method for Introducing Unnatural Amino Acids Site Specifically Into Proteins.” Methods in Enzymology, 202:301-336, 1991.
70. Shokat, K.M., Schultz, P.G. "Catalytic Antibodies.” Methods in Enzymology, 203:327-351, 1991.
71. Nakayama, G., Schultz, P.G. "Stereospecific Antibody-Catalyzed Reduction of an α-Keto Amide." J. Am. Chem. Soc., 114:780-781, 1992.
72. Ellman, J., Mendel, D., Schultz, P.G. "Site-Specific Incorporation of Novel Backbone Structures into Proteins." 255:197-20, 1992.
73. Gong, B., Lesley, S., Schultz, P.G. "A Chromogenic Assay for Screening Large Antibody Libraries." J. Am. Chem. Soc., 114:1486-1487, 1992.
74. Jackson, D.Y., Liang, M.N., Bartlett, P.A., Schultz, P.G. "Activation Parameters and Stereochemistry of an Antibody-Catalyzed Claisen Rearrangement." Angew. Chem. Int. Engl. Ed., 31:182-183, 1992.
75. Jacobsen, J., Schultz, P.G. "An Efficient Antibody-Catalyzed Aminoacylation Reaction." Science, 256:365-367, 1992.
76. Mendel, D., Ellman, J.A., Chang, Z., Veenstra, D.L., Kollman, P.A., Schultz, P.G. "Probing Protein Stability With Unnatural Amino Acids." Science, 256:1798-1802, 1992.
77. Oldenburg, K., Loganathan, D., Goldstein, I., Schultz, P.G., Gallop, M.A. "Peptide Ligands For a Sugar Binding Protein Isolated from a Random Peptide Library." Proc. Nat. Acad. Sci. (USA), 89:5393-5397, 1992.
78. Uno, T., Schultz, P.G. "An Antibody-Catalyzed Dehydration Reaction." J. Am. Chem. Soc., 114:6573-6574, 1992.
79. Rozsnyai, L., Benson, D.R., Fodor, S.P., Schultz, P.G. "Photolithographic Immobilization of Biopolymers on Solid Supports." Angew. Chem. Int. Engl. Ed., 31:759-761, 1992.
80. Schultz, P.G., Shokat, K.M. "Catalytic Antibodies: An Overview of Design Strategies and Their Applications." Welch Symposium Proceedings, pp. 19-42, 1991.
81. Ellman, J.A., Volkman, B.F., Mendel, D., Schultz, P.G., Wemmer, D.E. "Site-Specific Isotopic Labelling of Proteins for NMR Studies." J. Am. Chem. Soc., 114:7959-7961, 1992.
82. Jackson, D.Y., Schultz, P.G. "Progress Toward the Generation of Antibodies Containing Catalytic Dyads." New Aspects of Organic Chemistry II, 21:469-475, 1992.
83. Scanlan, T., Schultz, P.G. "Recent Advances in Catalytic Antibodies" Advances in Detailed Reaction Mechanisms; 2:1-22, 1992.
84. Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code." Science, 259:806-809, 1993.
85. Skerker, P.S., Jacobs, J.W., Clark, D.S., Schultz, P.G. "Probing a Catalytic Antibody Active Site Using Spin-Labelled Haptens." BioMed. Chem. Lett., 2:285-288, 1993.
86. Lesley, S.A., Patten, P.A., Schultz, P.G. "A Genetic Approach to the Generation of Antibodies with Enhanced Catalytic Activities." Proc. Natl. Acad. Sci. (USA), 90:1160-1165, 1993.
87. Hsieh, L.C., Yonkovich, S., Kochersperger, L., Schultz, P.G. "Controlling Chemical Reactivity with Antibodies." Science, 260:337-339, 1993.
88. Sarvetnick, N., Gurushanthaiah, D., Han, N., Prudent, J., Schultz, P., Lerner, R. "Increasing the Chemical Potential of the Germ-line Antibody Repertoire." Proc. Nat. Acad. Sci. (USA), 90:4008-4011, 1993.
89. Mendel, D., Ellman, J., Schultz, P.G. "Protein Biosynthesis with Conformationally Restricted Amino Acids." J. Am. Chem. Soc., 115(10):4359-4360, 1993.
90. Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Role of Lysine 16 in Ras p21 Protein with Unnatural Amino Acids." J. Am. Chem. Soc., 115(14):6414-6415, 1993.
91. Schultz, P.G., Lerner, R.A. "Antibody Catalysis of Difficult Chemical Transformations." J. Amer. Chem. Soc., 26(8):391-395, 1993.
92. Cho, C.Y., Moran, E.J., Cherry, S.R., Stephans, J.C., Fodor, S.P.A., Adams, C.L., Sundaram, A., Jacobs, J.W., Schultz, P.G. "An Unnatural Biopolymer." Science, 261:1303-1305, 1993.
93. Judice, J.K., Gamble, T.R., Murphy, E.C., de Vos, A.M., Schultz, P.G. "Probing the Mechanism of Staphylococcal Nuclease with Unnatural Amino Acids: Kinetic and Structural Studies." Science, 261:1578-1581, 1993.
94. Chung, H.H., Benson, D.R., Cornish, V.W., Schultz, P.G. "Probing the Role of Loop 2 in Ras Function with Unnatural Amino Acids." Proc. Natl. Acad. Sci. (USA), 90:10145-10149, 1993.
95. Angeles, T.S., Smith, R.G., Darsley, M.J., Sugasawara, R., Sanchez, R.I., Kenten, J., Schultz, P.G., Martin, M.T. "Isoabzymes: Structurally and Mechanistically Similar Catalytic Antibodies from the Same Immunization." Biochemistry, 32:12128-12135, 1993.
96. Pei, D., Schultz, P.G. "Artificial Nucleases." Nucleases, Cold Spring Harbor Laboratory, 317-340, 1993.
97. Uno, T., Gong, B., Schultz, P.G. "Stereoselective Antibody-Catalyzed Oxime Formation." J. Am. Chem. Soc., 116:1145-1146, 1994.
98. Chung, H., Schultz, P.G. "Probing Ras Function with Unnatural Amino Acids." Chemistry & Biology, 1:6-7, 1994.
99. Campbell, D.A., Gong, B., Kochersperger, L.M., Yonkovich, S., Gallop, M.A., Schultz, P.G. "Antibody-Catalyzed Prodrug Activation." J. Am. Chem. Soc., 116:2165-2166, 1994.
100. Hsieh, L.C., Stephans, J.C., Schultz, P.G. "An Efficient Antibody-Catalyzed Oxygenation Reaction." J. Am. Chem. Soc., 116:2167-2168, 1994.
101. Braisted, A.C., Schultz, P.G. "An Antibody-Catalyzed Oxy Cope Rearrangement." J. Am. Chem. Soc., 116:2211-2212, 1994.
102. Yu, J., Hsieh, L.C., Kochersperger, L., Yonkovich, S., Stephans, J.C., Gallop, M.A. Schultz, P.G. "Progress Toward An Antibody Glycosidase." Angew. Chem. Int. Engl. Ed., 33(3):339-341, 1994.
103. Shokat, K.M., Uno, T., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction." J. Am. Chem. Soc, 116:2261-2270, 1994.
104. Cornish, V.W., Benson, D.R., Altenbach, C.A., Hideg, K., Hubbell, W.L., Schultz, P.G. "Site Specific Incorporation of Biophysical Probes into Proteins." Proc. Natl. Acad. Sci. (USA), 91:2910-2914, 1994.
105. Huang, L., Sera, T., Schultz, P.G. "A Permutational Approach Toward Protein-DNA Recognition." Proc. Natl. Acad. Sci. (USA), 91:3969-3973, 1994.
106. Van Vranken, D.L., Panomitros, D., Schultz, P.G. "Catalysis of Carbamate Hydrolysis by an Antibody." Tetrahedron Letters, 35:3873-3876, 1994.
107. Prudent, J.R., Uno, T., Schultz, P.G. "Expanding the Scope of RNA Catalysis." Science, 264:1924-1927, 1994.
108. Jacobsen, J.R., Schultz, P.G. "Antibody Catalysis of Peptide Bond Formation." Proc. Natl. Acad. Sci. (USA), 91:5888-5892, 1994.
109. Johnsson, K., Schultz, P.G. "Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis." J. Am. Chem. Soc., 116:7425-7426, 1994.
110. Cornish, V.W., Schultz, P.G. "A New Tool for Studying Protein Structure and Function." Current Opinion in Structural Biology, 4:601-607, 1994.
111. Cornish, V.W., Kaplan, M.I., Veenstra, D.L., Kollman, P.A., Schultz, P.G. "Stabilizing and Destabilizing Effects of Placing a-Branched Amino Acids in Protein a-Helices." Biochemistry, 33:12022-12031, 1994.
112. Ku, J., Schultz, P.G. "Phage Display of Catalytically Active Staphlococcal Nuclease." Bioorg & Med. Chem., 2(12):1413-1415, 1994.
113. Thorson, J.S., Chapman, E., Murphy, E.C., Schultz, P.G. "Linear Free Energy Analysis of Hydrogen Bonding in Proteins." J. Am. Chem. Soc., 117:1157-1158, 1995.
114. Cornish, V.W., Mendel, D., Schultz, P.G. "Probing Protein Structure and Function with an Expanded Genetic Code." Angew. Chem. Int. Engl. Ed., 34:621-633, 1995.
115. Müller, W.T., Klein, D.L., Lee, T., Clarke, J., McEuen, P.L., Schultz, P.G. "A Strategy for the Chemical Synthesis of Nanostructures." 268:272-273, 1995.
116. Moran, E.J., Wilson, T.E., Cho, C.Y., Cherry, S.R., Schultz, P.G. "Novel Biopolymers for Drug Discovery." Peptide Science, 37:213-219, 1995.
117. Johnsson, K., King, D.S., Schultz, P.G. "Studies on the Mechanism of Action of Isoniazid and Ethionamide in the Chemotherapy of Tuberculosis." J. Am. Chem. Soc., 117:5009-5010, 1995.
118. Nowak, M.W., Kearney, P.C., Sampson, J.R., Saks, M.E., Labarca, C.G., Silverman, S.K., Zhong, W., Thorson, J., Abelson, J.N., Davidson, N., Schultz, P.G., Dougherty, D.A., Lester, H.A. "Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells." Science, 268:439-442, 1995.
119. Mendel, D., Cornish, V.W., Schultz, P.G. "Site-Directed Mutagenesis with an Expanded Genetic Code." Annu. Rev. Biophys. Biomol. Struct., 24:435-62, 1995.
120. Jacobsen, J.R., Cochran, A.G., Stephans, J.C., King, D.S., Schultz, P.G. "Mechanistic Studies of Antibody-Catalyzed Pyrmidine Dimer Photocleavage." J. Am. Chem. Soc., 117:5453-5461, 1995.
121. Xiang, X.-D., Sun, X., Briceño, G., Lou, Y., Wang, K.-A., Chang, H., Wallace-Freedman, W.G., Chen, S.-W., Schultz, P.G. "A Combinatorial Approach to Materials Discovery." Science, 268:1738-1740, 1995.
122. Ku, J., Schultz, P.G. "Alternate Protein Frameworks for Molecular Recognition." Proc. Natl. Acad. Sci. (USA), 92:6552-6556, 1995.
123. Thorson, J.S., Chapman, E., Schultz, P.G. "Analysis of Hydrogen Bonding Strengths in Proteins Using Unnatural Amino Acids." J. Am. Chem. Soc., 117:9361-9362, 1995.
124. Schultz, P.G., Lerner, R.A. "From Molecular Diversity to Catalysis: Lessons from the Immune System." Science, 269:1835-1842, 1995.
125. Prudent, J.R., Staunton, J., Schultz, P.G. "Probing the Structural Determinants of a Catalytic RNA with Isomerase Activity" J. Am. Chem. Soc., 117:10145-10146, 1995.
126. Briceño, G., Chang, H., Sun, X., Schultz, P.G., Xiang, X.D. "A Class of Cobalt Oxide Magnetoresistance Materials Discovered With Combinatorial Synthesis." Science, 270:273-275, 1995.
127. Cook, S.N., Jack, W.E., Xiong, X., Danley, L.E., Ellman, J.A., Schultz, P.G., Noren, C.J. "Photochemically Initiated Protein Splicing." Angew. Chem. Int. Engl. Ed., 34(15):1629-1630, 1995.
128. Jacobsen, J.R., Schultz, P.G. "The Scope of Antibody Catalysis." Curr. Opin. Struc. Bio., 5:818-824, 1995.
129. Ulrich, H.D., Patten, P.A., Yang, P.L., Romesberg, F.E., Schultz, P.G. "Expression Studies of Catalytic Antibodies." Proc. Natl. Acad. Sci. (USA), 92:11907-11911, 1995.
130. Patten, P.A., Gray, N.S., Yang, P.L., Marks, C.B., Wedemayer, G.J., Boniface, J.J., Stevens, R.G., Schultz, P.G. "The Immunological Evolution of Catalysis." Science, 271:1086-1091, 1996.
131. Cload, S.T., Liu, D.R., Pastor, R.M., Schultz, P.G. "Mutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilis." J. Am. Chem. Soc., 118(7):1787-1788, 1996.
132. Liu, D.R., Cload, S.T., Pastor, R.M., Schultz, P.G. "Analysis of Active Site Residues in Escherichia coli Chorismate Mutase by Site-Directed Mutagenesis." J. Am. Chem. Soc., 118(7):1789-1790, 1996.
133. Hsieh-Wilson, L.C., Xiang, X.-D., Schultz, P.G. "Lessons from the Immune System: From Catalysis to Materials Science." Accts. Chem. Res., 29(3):164-170, 1996.
134. Sera, T., Schultz, P.G. "In Vivo Selection of Basic Region-Leucine Zipper Proteins with Altered DNA Binding Specificities." Proc. Natl. Acad. Sci. (USA), 93:2920-2925, 1996.
135. Uno, T., Ku, J., Prudent, J.R., Huang, A., Schultz, P.G. "An Antibody-Catalyzed Isomerizaton Reaction." J. Am. Chem. Soc., 118(16):3811-3817, 1996.
136. Ulrich, H.D., Driggers, E.M.G., Schultz, P.G. "Antibody Catalysis of Pericyclic Reactions." Acta Chemica Scandinavica, 50:328-332, 1996.
137. Hsieh-Wilson, L.C., Schultz, P.G., Stevens, R.C. "Insights into Antibody Catalysis: Structure of an Oxygenation Catalyst at 1.9-Å Resolution." Proc. Natl. Acad. Sci. (USA), 93:5363-5367, 1996.
138. Fan, E., Oei, Y., Sweet, E., Uno, T., Schultz, P.G. "Antibodies with Thiol-s-Transferase Activity." J. Am. Chem. Soc., 118: 5474-5475, 1996.
139. Flanagan, M.E., Jacobsen, J.R., Sweet, E., Schultz, P.G. "Antibody-Catalyzed Retro-Aldol Reaction." J. Am. Chem. Soc., 118(23):6078-6079, 1996.
140. Conn, M.M., Prudent, J.R., Schultz, P.G. "Porphyrin Metalation Catalyzed by a Small RNA Molecule." J. Am. Chem. Soc., 118(25):7012-7013, 1996.
141. Norman, T.C., Gray, N.S., Koh, J.T., Schultz, P.G. "A Structure-Based Library Approach to Kinase Inhibitors." J. Am. Chem. Soc., 118(29):7430-7431, 1996.
142. Wei, T., Xiang, X.-D., Wallace-Freedman, W.G., Schultz, P.G. "Scanning Tip Microwave Near Field Microscope." Appl. Phys. Lett., 68(24):3506-3508, 1996.
143. Cornish, V.W., Hahn, K.M., Schultz, P.G. "Site-Specific Protein Modification Using a Ketone Handle." J. Am. Chem. Soc., 118(34):8150-8151, 1996.
144. Alivisatos, A.P., Johnsson, K.P., Peng, X., Wilson, T.E., Loweth, C.J., Bruchez, Jr. M.P., Schultz, P.G. "Organization of ‘Nanocrystal Molecules’ Using DNA." Nature, 382:609-611, 1996.
145. Prudent, J.R., Schultz, P.G. "RNA Catalysis and Transition State Stabilization." Nucleic Acids and Mol. Biology; (Edt., F. Eckstein and D.M.J. Lilley: Berlin), 10:383-395, 1996.
146. Kim, J.M., Bi, Y., Paikoff, S.J., Schultz, P.G. "The Solid Phase Synthesis of Oligoureas." Tet. Lett., 37(30):5305-5308, 1996.
147. Kim, J.M., Wilson, T.E., Norman, T.C., Schultz, P.G. "Synthesis of a Cyclic Urea as a Nonnatural Biopolymer Scaffold." Tet. Lett., 37(30):5309-5312, 1996.
148. Paikoff, S.J., Wilson, T.E., Cho, C.Y., Schultz, P.G. "The Solid Phase Synthesis of N-Alkylcarbamate Oligomers." Tet. Lett., 37(32):5653-5656, 1996.
149. Bi, Y., Schultz, P.G. "Building Blocks for Peptide and Carbamate Libraries." Bioorg. Med. Chem. Lett., 6(19):2299-2300, 1996.
150. Driggers, E.M., Schultz, P.G. "Catalytic Antibodies." Adv. Protein Chem, 49:261-287, 1996.
151. Yoon, S.S., Oei, Y., Sweet, E., Schultz, P.G. "An Antibody-Catalyzed [2,3]-Elimination Reaction." J. Am. Chem. Soc., 118(46):11686-11687, 1996.
152. Stevens, R.C., Hsieh-Wilson, L.C., Santarsiero, B.D., Wedemayer, G.J., Spiller, B., Wang, L.H., Barnes, D., Ulrich, H.D., Patten, P.A., Romesberg, F.E., Schultz, P.G. "Structural Studies of Catalytic Antibodies." Israel J. of Chem., 36:121-132, 1996.
153. Cload, S.T., Liu, D.R., Froland, W.A., Schultz, P.G. "Development of Improved tRNAs for In Vitro Biosynthesis of Proteins Containing Unnatural Amino Acids." Chem. & Biology, 3:1033-1038, 1996.
154. Kanamori, T., Nishikawa, S.-I., Shin, I., Schultz, P.G., Endo, T. "Probing the Environment Along the Protein Import Pathways in Yeast Mitochondria by Site-Specific Photocrosslinking." Proc. Natl. Acad. Sci. (USA), 94:485-490, 1997.
155. Peng, X., Wilson, T.E., Alivisatos, A.P., Schultz, P.G. "Synthesis and Isolation of a Homodimer of Cadmium Selenide Nanocrystals." Angew. Chem. Int. Engl. Ed., 36(112):145-147, 1997.
156. Johnsson, K., Froland, W.A., Schultz, P.G. "Overexpression, Purification and Characterization of the Catalase-Peroxidase KatG from Mycobacterium tuberculosis." J. Biol. Chem., 272(5):2834-2840, 1997.
157. Gray, N.S., Kwon, S., Schultz, P.G. "Combinatorial Synthesis of 2,9-Substituted Purines." Tet. Lett., 38(7):1161-1164, 1997.
158. Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C. "Crystal Structures of the Free and Liganded Form of an Esterolytic Catalytic Antibody." J. Mol. Biol., 268:390-400, 1997.
159. Wedemayer, G.J., Patten, P.A., Wang, L.H., Schultz, P.G., Stevens, R.C. "Structural Insights into the Evolution of an Antibody Combining Site." Science, 276:1665-1669, 1997.
160. Sun, X.D., Gao, C., Wang, J., Xiang, X.-D., Schultz, P.G. "Identification and Optimization of Advanced Phosphors Using Combinatorial Libraries." Appl. Phys. Lett., 70:1-4, 1997.
161. Chapman, E., Thorson, J.S., Schultz, P.G. "Mutational Analysis of Backbone Hydrogen Bonds in Staphylococcal Nuclease." J. Am. Chem. Soc., 119(30):7151-7152, 1997.
162. Lu, Y., Wei, T., Duewer, F., Lu, Y., Ming, N.B., Schultz, P.G., Xiang, X.D. "Nondestructive Imaging of Dielectric-Constant Profiles and Ferroelectric Domains with a Scanning-Tip Microwave Near-field Microscope." Science, 276:2004-2006, 1997.
163. Park, Y., Luo, J., Schultz, P.G., Kirsch, J.F. "Noncoded Amino Acid Replacement Probes of the Aspartate Aminotransferase Mechanism." Biochemistry, 36(34):10517-10525, 1997.
164. Liu, D.R., Magliery, T.J., Pastrnak, M., Schultz, P.G. "Engineering a tRNA and Aminoacyl-tRNA Synthetase for the Site-Specific Incorporation of Unnatural Amino Acids into Proteins in Vivo" Proc. Nat. Acad. Sci.(USA), 94:10092-10097, 1997.
165. Ulrich, H.D., Mundorff, E., Santarsiero, B.D., Driggers, E.M., Stevens, R.C., Schultz, P.G. "The Interplay Between Binding Energy and Catalysis in the Evolution of a Catalytic Antibody." Nature, 389:271-275, 1997.
166. Koh, J.T., Cornish, V.W., Schultz, P.G. "An Experimental Approach to Evaluating the Role of Backbone Interactions in Proteins Using Unnatural Amino Acid Mutagenesis." Biochemistry, 36(38):11314-11322, 1997.
167. Xiang, X.-D., Schultz, P.G. "The Combinatorial Synthesis and Evaluation of Functional Materials." Physica C, 282:428-430, 1997.
168. Liu, D.R., Magliery, T.J., Schultz, P.G. "Characterization of an ‘Orthogonal’ Suppressor tRNA Derived from E. coli tRNA2Gln." Chem. & Biology, 4:685-691, 1997.
169. Yu, J., Choi, S.Y., Lee, S., Yoon, H.J., Jeong, S., Mun, H., Park, H., Schultz, P.G. "Antibody-Catalyzed Glycosyl Transfer Reactions From In Vitro Immunization." Chem. Commun., 20:1957-1958, 1997.
170. Hall, D.G., Schultz, P.G. "Synthesis of Diverse Ethoxyformacetal Oligomers. Toward Libraries of Metal-Coordinating Unnatural Biopolymers." Tetrahedron Lett., 38(45):7825-7828, 1997.
171. Sun, X.-D., Wang, K-A., Yoo, Y., Wallace-Freedman, W.G., Gao, C., Xiang, X-D., Schultz, P.G. "Solution-Phase Synthesis of Luminescent Materials Libraries." Adv. Materials, 9(13):1046-1049, 1997.
172. Shin, I., Ting, A.Y., Schultz, P.G. "Analysis of Backbone Hydrogen Bonding in a b-turn of Staphylococcal Nuclease" J. Am. Chem. Soc., 119(51):12667-12668, 1997.
173. Ulrich, H.D., Schultz, P.G. "Analysis of Hapten Binding and Catalytic Determinants in a Family of Catalytic Antibodies" J. Mol. Biol., 275:95-111, 1998.
174. Ulrich, H.D., Moore, F.L., Schultz, P.G. "Germline diversity within the mouse Igk-V9 gene family." Immunogenetics, 47:91-95, 1997.
175. Yu, J., Choi, S.Y., Moon, K-D., Chung, H-H., Youn, H.J., Jeong, S., Park, H., Schultz, P.G. "A Glycosidase Antibody Elicited Against a Chair-like Transition State Analog Using in vitro Immunization." Proc. Nat. Acad. Sci. (USA), 95:2880-2884, 1998.
176. Barrett, J.E., Maltby, D.A., Santi, D.V., Schultz, P.G. "Trapping of the C5 Methylene Intermediate in Thymidylate Synthase." J. Am. Chem. Soc., 120(2):449-450, 1998.
177. Thorson, J.S., Shin, I., Chapman, E., Stenberg, G., Mannervik, B., Schultz, P.G. "Analysis of the Role of the Active Site Tyrosine in Human Glutathione Transferase A1-1 by Unnatural Amino Acid Mutagenesis." J. Am. Chem. Soc., 120(2):451-452, 1998.
178. Blackwood, M.E., Jr., Rush, T.S. III, Romesberg, F., Schultz, P.G., Spiro, T.G. "Alternative Modes of Substrate Distortion in Enzyme and Antibody Catalyzed Ferrochelation Reactions." Biochemistry, 37(3):779-782, 1998.
179. Wang, J., Yoo, Y., Gao, C., Takeuchi, I., Sun, X., Chang, H., Xiang, X.-D., Schultz, P.G. "Identification of a Blue Photoluminescent Composite Material from a Combinatorial Library." Science, 279:1712-1714, 1998.
180. Schultz, P.G., Xiang, X.D. "Combinatorial Approaches to Materials Science." Curr. Opin. Solid State and Mat. Sci., 3:153-158, 1998.
181. Romesberg, F.E., Spiller, B., Schultz, P.G., Stevens, R.C. "Immunological Origins of Binding and Catalysis in a Diels-Alderase Antibody." Science, 279:1929-1933, 1998.
182. Driggers, E.M., Cho, H.S., Liu, C.W., Katzka, C.P., Braisted, A.C., Ulrich, H.D., Wemmer, D.E., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Pericyclic Rearrangement." J. Am. Chem. Soc., 120(9):1945-1958, 1998.
183. Chang, H., Gao, C., Takeuchi, I., Yoo, Y., Wang, J., Schultz, P.G., Xiang, X.D., Sharma, R.P., Downes, M., Venkatesan, T. "Combinatorial Synthesis and High Throughput Evaluation of Ferroelectric/Dielectric Thin-Film Libraries for Microwave Applications." Appl. Phys. Lett., 72(17):2185-2187, 1998.
184. Ma, L., Hsieh-Wilson, L.C., Schultz, P.G. "Antibody Catalysis of Peptidyl-prolyl cis-trans Isomerization in the Folding of RNase T1." Proc. Natl. Acad. Sci. (USA), 95:7251-7256, 1998.
185. Romesberg, F.E., Flanagan, M.E., Uno, T., Schultz, P.G. "Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction." J. Am. Chem. Soc., 120(21):5160-5167, 1998.
186. Ting, A.Y., Shin, I., Lucero, C., Schultz, P.G. "Energetic Analysis of an Engineered Cation-p Interaction in Staphylococcal Nuclease." J. Am. Chem. Soc., 120(28):7135-7136, 1998.
187. Driggers, E.M., Liu, C.W., Wemmer, D.E., Schultz, P.G. "Structure of the Michaelis Complex of an Efficient Antibody Acyl Transferase Determined by Transferred Nuclear Overhauser Enhancement Spectroscopy." J. Am. Chem. Soc., 120(29):7395-7396, 1998.
188. Cho, C.Y., Youngquist, R.S., Paikoff, S.J., Beresini, M.H., Hebert, A.R., Berleau, L.T., Liu, C.W., Wemmer, D.E., Keough, T., Schultz, P.G. "Synthesis and Screening of Linear and Cyclic Oligocarbamate Libraries. Discovery of High Affinity Ligands for GP11b/IIIa." J. Am. Chem. Soc., 120(31):7706-7718, 1998.
189. Thorson, J.S., Cornish, V.W., Barrett, J.E., Cload, S.T., Yano,T., Schultz, P.G. "A Biosynthetic Approach for the Incorporation of Unnatural Amino Acids into Proteins." Methods in Molecular Biology, 77:43-73, 1998.
190. Gray, N.S. Wodicka, L., Thunnissen, A.M. W.H., Norman, T.C., Kwon, S., Hernan Espinoza, F., Morgan, D.O., Barnes, G., LeClerc, S., Meijer, L., Kim, S.H., Lockhart, D. J., Schultz, P.G. "Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors." Science, 281:533-538, 1998.
191. Pedersen, H., Hölder, S., Sutherlin, D.P., Schwitter, U., King, D.S., Schultz, P.G. "A Method for Directed Evolution and Functional Cloning of Enzymes." Proc. Natl. Acad. Sci. (USA), 95:10523-10528, 1998.
192. Pollitt, S.K., Schultz, P.G. "A Photochemical Switch for Controlling Protein-Protein Interactions." Angew. Chem. Int. Engl. Ed., 37(15):2104-2107, 1998.
193. Romesberg, F.E., Santarsiero, B.D., Spiller, B., Yin J., Barnes, D., Schultz, P.G., Stevens, R.S. "Structural and Kinetic Evidence for Strain in Biological Catalysis." Biochemistry, 37(41):14404-14409, 1998.
194. Isaacs, E.D., Marcus, M.A., Aeppli, G., Xiang, X.-D., Sun, X., Schultz, P.G., Kao, M., Cargill, G.S. III, Haushalter, R. "Synchrotron X-ray Microbeam Diagnostics of Combinatorial Synthesis." Applied Physics Letters, 73:1820-1822, 1998.
195. I. Takeuchi, H. Chang, C. Gao, P.G. Schultz, X.-D. Xiang, R.P. Sharma, M.J. Downes, T. Venkatesan "Combinatorial Synthesis and Evaluation of Epitaxial Ferroelectric Device Libraries.” Applied Physics Letters, 73(31):894, 1998.
196. Loweth, C.J., Caldwell, W.B., Peng, X., Alivisatos, A.P., Schultz, P.G. "DNA-Based Assembly of Gold Nanocrystals." Angew. Chem. Int. Engl. Ed., 38(12):1808-1812, 1999.
197. Rosania, G.R., Merlie, J.Jr, Gray, N., Chang, Y.T., Schultz, P.G., Heald, R. "A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: Biochemical identification using Xenopus egg extracts." Proc. Natl. Acad. Sci. (USA), 96:4797-4802, 1999.
198. Liu, Y., Barrett, J.E., Schultz, P.G., Santi, D.V. "Tyrosine 146 of Thymidylate Synthase Assists Proton Abstraction from the 5-Position of 2'-Deoxyuridine 5'-Monophosphate." Biochemistry, 38:848-852, 1999.
199. Cho, C.Y., Liu, C.W., Wemmer, D.E., Schultz, P.G. "Cyclic and Linear Oligocarbamate Ligands for Human Thrombin." Bioorganic & Medicinal Chemistry, 7:1171-1179, 1999.
200. Ha, T., Ting, A.Y., Liang, J., Caldwell, W.B., Deniz, A.A., Chemla, D.S., Schultz, P.G., Weiss, S. "Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism." Proc. Natl. Acad. Sci. (USA), 96:893-898, 1999.
201. Liu, D.R., Schultz, P.G. "Generating New Molecular Function: A Lesson From Nature." Angew. Chem. Int. Engl. Ed., 38:36-54, 1999.
202. Chang, Y.T., Gray, N.S., Rosania, G.R., Sutherlin, D.P., Kwon, S., Norman, T.C., Sarohia, R., Leost, M., Meijer, L., Schultz, P.G. "Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors." Chemistry & Biology, 6:361-375, 1999.
203. Liu, D.R., Schultz, P.G. "Progress toward the evolution of an organism with an expanded genetic code." Proc. Natl. Acad. Sci. (USA), 96:4780-4785, 1999.
204. Kanamori, T., Nishikawa, S.I., Nakai, M., Shin, I., Schultz, P.G., Endo, T. "Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane." Proc. Natl. Acad. Sci. (USA), 96:3634-3639, 1999.
205. Romesberg, F.E., Schultz, P.G. "A Mutational Study of a Diels-Alderase Catalytic Antibody." Bioorg. Med. Chem. Lett., 9:1741-1744, 1999.
206. Yao, S., Anex, D.S., Caldwell, W.B., Arnold, D.W., Smith, K.B, Schultz, P.G. "SDS capillary gel electrophoresis of proteins in microfabricated channels." Proc. Natl. Acad. Sci. (USA),96:5372-5377, 1999.
207. Deniz, A.A., Dahan, M., Grunwell, J.R., Ha, T., Faulhaber, A.E., Chemla, D.S., Weiss, S., Schultz, P.G. “Single Pair Fluorescence Resonance Energy Transfer on Freely Diffusing Molecules: Observation of Förster Distance Dependence and Subpopulations.” Proc. Natl. Acad. Sci. (USA),96:3670-3675, 1999.
208. Dahan, M., Deniz, A.A., Ha, T., Chemla, D.S., Schultz, P.G., Weiss, S. “Ratiometric Measurement and Identification of Single Diffusing Molecules.” Chemical Physics, 247:85-106, 1999.
209. Barrett, J.E., Lucero, C.M., Schultz, P.G. “A Model for Hydride Transfer in Thymidylate Synthase Based on Unnatural Amino Acid Mutagenesis." J. Am. Chem. Soc., 121(34):7965-7966, 1999.
210. Chang, Y.-T., Schultz, P.G. "Versatile Fluorescence Labeling Method Using Activated Esters on Solid Support.” Bioorg. Med. Chem. Lett., 9:2479-2482, 1999.
211. Ma, L., Sweet, E.H., Schultz, P.G. “Selective Antibody-Catalyzed Solvolysis of endo-2-Norbornyl Mesylate.” J. Am. Chem. Soc., 121:10227-10228, 1999.
212. Martin, A., Schultz, P.G. “Opportunities at the Interface of Chemistry and Biology.” TiBS, 24:M24-M28, 1999.
213. Yang, P.L., Schultz, P.G. “Mutational Analysis of the Affinity Maturation of Antibody 48G7.” J. Mol. Bio., 294:1191-1201, 1999.
214. Ha, T.J., Ting, A.Y., Liang, J., Deniz, A.A., Chemla, D.S., Schultz, P.G., Weiss, S. “Temporal Fluctuations of Fluorescence Resonance Energy Transfer Between Two Dyes Conjugated to a Single Protein.” Chemical Physics, 247(1):107-118, 1999.
215. McMinn, D.L., Ogawa, A.K., Wu, Y., Liu, J., Schultz, P.G., Romesberg, F.E. “Efforts Toward Expansion of the Genetic Alphabet: DNA Polymerase Recognition of a Highly Stable, Self-Pairing Hydrophobic Base.” J. Am. Chem. Soc., 121(49):11585-11586, 1999.
216. Mundorff, E.C., Hanson, M.A., Varvak, A., Ulrich H., Schultz, P.G., Steven, R.C. “Conformational Effects in Biological Catalysis: An Antibody-Catalyzed Oxy-cope Rearrangement.” Biochemistry, 39(4):627-632, 2000.
217. Rosania, G.R., Chang, Y.T., Perez, O., Sutherlin, D., Dong, H., Lockhart, D. J., Schultz, P.G. “Myoseverin: A Microtubule-Binding Molecule with Novel Cellular Effects.” Nature Biotechnology, 18:304-308, 2000.
218. Ly, D.H., Lockhart, D.J., Lerner, R.A., Schultz, P.G. “Mitotic Misregulation and Human Aging.” Science, 287:2486-2492, 2000.
219. Armstrong, J.I., Portley, A.R., Chang, Y.T., Nierengarten, D.M., Cook, B.N., Bowman, K.G., Bishop, A., Gray, N.S., Shokat, K.M., Schultz, P.G., Bertozzi, C.R. “Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library.” Angew. Chem. Int. Ed., 39(7):1303-1306, 2000.
220. Deniz, A.A., Laurence, T.A., Beligere, G.S., Dahan, M., Martin, A.B., Chemla, D.S., Dawson, P.E., Schultz, P.G., Weiss, S. “Single-molecule Protein Folding: Diffusion Fluorescence Resonance Energy Transfer Studies of the Denaturation of Chymotrysin Inhibitor 2.” Proc. Natl. Acad. Sci. (USA), 97(10):5179-5184, 2000.
221. Knockaert, M., Gray, N., Damiens, E., Chang, Y.T., Grellier, P., Grant, K., Fergusson, D., Mottram, J., Soete, M., Dubremetz, J.F., Le Roch, K., Doerig, C., Schultz, P.G., Meijer, L. “Intracellular Targets of Cyclin-dependent Kinase Inhibitors: Identification By Affinity Chromatography Using Immobilised Inhibitors.” Chemistry & Biology, 7:411-422, 2000.
222. Ogawa, A.K., Wu, Y., McMinn, D. L., Liu, J., Schultz, P.G., Romesberg, F.E. “Efforts Toward the Expansion of the Genetic Alphabet: Information Storage and Replication with Unnatural Hydrophobic Base Pairs.” J. Am. Chem. Soc., 122:3274-3287, 2000.
223. Guo Z., Zhou, D., Schultz, P.G. “Designing Small Molecule Switches for Protein-Protein Interactions.” Science, 288:2042-2045, 2000.
224. Wang, L., Magliery, T.J., Liu, D.R., Schultz, P.G. “A New Functional Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for the in vivo Incorporation of Unnatural Amino Acids into Proteins.” J. Am. Chem. Soc., 122:5010-5011, 2000.
225. Berger, M., Ogawa, A.K., McMinn, D.L., Wu, Y., Schultz, P.G., Romesberg, F.E. “Stable and Selective Hybridization of Oligonucleotides with Unnatural Hydrophobic Bases.” Angew. Chem. Int. Ed., 39(16):2940-2942, 2000.
226. Wu, Y., Ogawa, A.K., Berger, M., McMinn, D.L., Schultz, P.G., Romesberg, F.E. “Efforts Toward Expansion of the Genetic Alphabet: Optimization of Interbase Hydrophobic Interactions.” J. Am. Chem. Soc., 122(32):7621-7632, 2000.
227. Berger, M., Wu, Y., Ogawa, A.K., McMinn, D.L., Schultz, P.G., Romesberg, F.E. “Universal Bases for Hybridizaton, Replication and Chain Termination.” Nucleic Acids Res., 28(15):2911-2914, 2000.
228. Ogawa, A.K., Wu, Y., Berger, M., Schultz, P.G., Romesberg, F.E. “Rational Design of an Unnatural Base Pair with Increased Kinetic Selectivity.” J. Am. Chem. Soc., 122:8803-8804, 2000.
229. Bishop, A.C., Ubersax, J.A., Petsch, D.T., Matheos, D.P., Gray, N.S., Blethrow, J., Shimizu, E., Tsien, J.Z., Schultz, P.G., Rose, M.D., Wood, J.L., Morgan, D.O., Shokat, K.M. “A Chemical Switch for Inhibitor-sensitive Alleles of any Protein Kinase.” Nature, 407:395-401, 2000.
230. Meggers, E., Holland, P.L., Tolman, W.B., Romesberg, F.E., Schultz, P.G. “A Novel Copper-Mediated DNA Base Pair.” J. Am. Chem. Soc., 122:10714-10715, 2000.
231. Pastrnak, M., Magliery, T.J., Schultz, P.G. “A New Orthogonal Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for Evolving an Organism with an Expanded Genetic Code.” Helvetica Chimica Acta, 83:2277-2286, 2000.
232. Rampon, C., Jiang, C.H., Dong, H., Tang, Y. Lockhart, D.J., Schultz, P.G., Tsien, J.Z., Hu, Y. “The Effects of Environmental Enrichment on Gene Expression in the Brain.” Proc. Nat. Acad. Sci. (USA), 97(23):12880-12884, 2000.
233. Simeonov, A., Matsushita, M., Juban, E.A., Thompson, E.H.Z., Hoffman, T.Z., Beuscher IV, A.E., Taylor, M.J., Wirsching, P., Rettig, W., McCusker, J.K., Stevens, R.C., Millar, D.P., Schultz, P.G., Lerner, R.A., Janda, K.D. “Blue-Fluorescent Antibodies.” Science, 290:307-313, 2000.
234. Harmse, L., van Zyl, R., Gray, N., Schultz, P.G., Leclerc, S., Meijer, L., Doerig, C., Havlik, I. “Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.” Biochem. Pharmacol., 62:341-348, 2001.
235. Deniz, A.A., Laurence, T.A., Dahan, M., Chemla, D.S., Schultz, P.G., Weiss, S. “Ratiometric Single-Molecule Studies of Freely Diffusing Biomolecules.” Annual Reviews of Physical Chemistry, 52:233-253, 2001.
236. Simbulan-Rosenthal, C.M., Ly, D.H., Rosenthal, D.S., Konopka, G., Luo, R., Wang, Z.-Q., Schultz, P.G., Smulson, M.E. “Misregulation of Gene Expression in Primary Fibroblasts Lacking poly(ADP-ribose) Polymerase.” Proc. Nat. Acad. Sci. (USA), 97(21):11274-11279, 2001.
237. Jiang, C.H., Tsien, J.Z., Schultz, P.G., Hu, Y. “The Effects of Aging on Gene Expression in the Hypothalmus and Cortex of Mice.” Proc. Nat. Acad. Sci., (USA), 98(4):1930-1934, 2001.
238 Lu, T., Ting, A., Mainland, J., Jan, L.Y., Schultz, P.G., Yang, J. “Probing Ion Permeation and Gating in a K+ Channel with Backbone Mutations in the Selectivity Filter.” Nature Neuroscience, 4(3):239-246, 2001.
239. Magliery, T.J., Anderson, J.C., Schultz, P.G. “Expanding the Genetic Code: Selection of Efficient Suppressors of Four-Base Codons and Identification of “Shifty.” Four-Base Codons with a Library Approach in Escherichia coli.” J. Mol. Biol., 307:755-769, 2001.
240. Wang, L., Brock, A., Herberich, B., Schultz, P.G. “Expanding the Genetic Code of Escherichia coli.” Science, 292:498-500, 2001.
241. Verdugo, D.E., Cancilla, M.T., Ge, X., Gray, N.S., Chang, Y.T., Schultz, P.G., Negishi, Masahiko, Leary, J.A., Bertozzi, C.R. “Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen.” J. Med. Chem., 44:2683-2686, 2001.
242. Hogenesch, J.B., Ching, K.A., Batalov, S., Su, A.I., Walker, J.R., Zhou, Y., Kay, S.A., Schultz, P.G. Cooke, M.P. “A Comparision of the Celera and Ensembl Predicted Gene Sets Reveals Little Overlap in Novel Genes.” Cell, 106:1-3, 2001.
243. Watanabe, C., Wolffram, S., Ader, P., Rimbach, G., Packer, L., Maguire, J., Schultz, P.G., Gohil, K. “The In vivo Neuromodulatory Effects of the Herbal Medicine Ginkgo Biloba.” Proc. Nat. Acad. Sci., (USA) 98(12):6577-6580, 2001.
244. Winssinger, N., Harris, J.L., Backes, B.J., Schultz, P.G. “From Split-Pool Libraries to Spatially Addressable Microarrays and its Application to Functional Proteomic Profiling.” Angew. Chem., Int. Engl. Ed. 40(17):3152-3155, 2001.
245. Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G. “A Comparative Analysis of the Immunological Evolution of Antibody 28B4.” Biochemistry, 40(36):10764-10773, 2001.
246. Spence, M.M., Rubin,S.M., Dimitrov, I.E., Ruiz, E.J., Wemmer, D.E., Pines, A., Yao, S.Q., Tian, F., Schultz, P.G. “Functionalized Xenon as a Biosensor.” Proc. Nat. Acad. Sci., (USA) 98(19):10654-10657, 2001.
247. Wang, L., Schultz, P.G. “A General Approach for the Generation of Orthogonal tRNAs.” Chemistry and Biology, 8:883-890, 2001.
248. Pastrnak, M., Schultz, P.G. “Phage Selection for Site-Specific Incorporation of Unnatural Amino Acids into Proteins in vivo.” Bioorganic and Med. Chem., 9:2373-2379, 2001.
249. Su, A.I., Welsh, J.B., Sapinosa, L.M., Kern, S.G., Dimitrov., P., Lapp, H., Schultz, P.G., Powell, S.M., Moskaluk, C.A., Frierson, H.F. Jr., Hampton, G.M. “Molecular Classification of Human Carcinomas by Use of Gene Expression Signatures.” Cancer Research, 61:7388-7393, 2001.
250. Grunwell, J.R., Glass, J.L., Lacoste, T.D., Ashok, A.D., Chemla, D.S., Schultz, P.G. “Monitoring the Conformational Fluctuations of DNA Hairpins Using Single-Pair Fluorescence Resonance Energy Transfer.” J. Am. Chem. Soc., 123:4295-4303, 2001.
251. Tae, E.L., Wu, Y., Xia, G., Schultz, P.G., Romesberg, F.E. “Efforts toward Expansion of the Genetic Alphabet: Replication of DNA with Three Base Pairs.” J. Am. Chem. Soc., 123:7439-7440, 2001.
252. Ding, S., Ding, Q., Gray, N.S., Schultz, P.G. “Expanding the Diversity of Purine Libraries.” Tetrahedron Letters, 42:8751-8755, 2001.
253. Wu, T.Y.H., Ding, S., Gray, N.S., Schultz, P.G. “Solid-Phase Synthesis of 2,3,5-Trisubstituted Indoles.” Organic Letters, 3(24):3827-3830, 2001.
254. Lin, Q., Jiang, F., Schultz, P.G., Gray, N.S. “Design of Allele-Specific Protein Methyltransferase Inhibitors.” J. Am. Chem. Soc., 123(47):11608-11613, 2001.
255. Atwell, S., Meggers, E., Spraggon, G., Schultz, P.G. “Structure of a Copper-Mediated Base Pair in DNA.” J. Am. Chem. Soc., 123(49):12364-12367, 2001.
256. Mody, M., Cao, Y., Cui, Z., Tay, K.Y., Shyong, A., Shimizu, E., Pham, K., Schultz, P.G., Welsh, D., Tsien, J.Z. “Genome-Wide Gene Expression Profiles of the Developing Mouse Hippocampus.” Proc. Nat. Acad. Sci., (USA), 98(15): 8862-8867, 2001.
257. Ting, A.Y., Witte, K., Shah, K., Kraybill, B., Shokat, K., Schultz, P.G. “Phage-Display Evolution of Tyrosine Kinases with Altered Nucleotide Specificity.” Biopolymers, 60:220-228, 2001.
258. Ding, S., Gray, N. S., Ding, Q., Schultz, P.G. “A Concise and Traceless Linker Strategy toward Combinatorial Libraries of 2,6,9-Substituted Purines.” J. Org. Chem., 66:8273-8276, 2001.
260. Block-Alper, L., Webster, P., Zhou, X., Supekova, L., Wong, W.H., Schultz, P.G., Meyer, D.I. “INO2, a Positive Regulator of Lipid Biosynthesis, Is Essential for the Formation of Inducible Membranes in Yeast.”Mol. Biol. Cell, 13:40-51, 2002.
261. Wang, L., Schultz, P.G. “Expanding the Genetic Code.” Chem. Comm., 1:1-11, 2002.
262. Anderson, J.C., Magliery, T.J., Schultz, P.G. “Exploring the Limits of Codon and Anticodon Size.” Chemistry & Biology, 9:237-244, 2002.
263. Watanabe, C., Supekova, L., and Schultz, P.G. “The Transcriptional Effects to the Potent Enediyne Anti-Cancer Agent Calicheamicin λ1I.”Chemistry & Biology, 9:245-251, 2002.
264. Ding, S., Gray, N.S., Wu, X., Ding, Q., Schultz, P.G. “A Combinatorial Scaffold approach towards Kinase-Directed Heterocycle Libraries.” J. Am. Chem. Soc., 124(8):1594-1596, 2002.
265. Wang, L., Brock, A., Schultz, P.G. “Adding L-3-(2-Naphthyl)alanine to the Genetic Code of E. Coli.” J. Am. Chem. Soc., 124(9):1836-1837, 2002.
266. Ding, S., Gray, N.S. Ding, Q., Wu, X., Schultz, P.G. “Resin-Capture and Release Strategy toward Combinatorial Libraries of 2,6,9-Substituted Purines.” J. Comb. Chem., 4(2):183-186, 2002.
267. Su, A.I., Cooke, M., Ching, K., Hakak, Y., Walker, J., Wiltshire, T., Orth, A.P., Vega, R., Sapinoso, L., Moqrich, A., Patapoutian, A., Hampton, G., Schultz, P.G., Hogenesch J.B. “Large-scale Analysis of the Human and Mouse Tanscriptomes.” Pro. Nat. Acad. Sci. (USA), 99(7):4465-4470, 2002.
268. Panda, S., Antoch, M.P., Miller, B.H., Su, A.I., Schook, A.B., Straume, M., Schultz, P.G., Kay, S.A., Takahashi, J.S., Hogenesch, J.B. “Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock.” Cell, 109:307-320, 2002.
269. Xia, G., Chen, L., Sera, T., Fa, M., Schultz, P.G., Romesberg, F.E. “Directed evolution of novel polymerase activities: Mutation of a DNA polymerase into an efficient RNA polymerase.” Pro. Nat. Acad. Sci. (USA), 99(10):6597-6602, 2002.
270. Santarsiero, B.D., Yegian, D.T., Lee, C.C., Spraggon, G., Gu, J., Scheibe, D., Uber, D.C., Cornell, E.W., Nordmeyer, R.A., Kolbe, W.F., Jin, J., Jones, A.L., Jaklevic, J.M., Schultz, P.G., and Stevens, R.C. “An Approach to Rapid Protein Crystallization Using Nanodroplets.” J. Applied Crystallography, 35:278-281, 2002.
271. Damoiseaux, R., Schultz, P.G., Johnsson, K. “Towards the Generation of Artificial O6-Alkylguanine-DNA Alkyltransferases: in vitro Selection of Antibodies with Reactive Cysteine Residues.” Chem Bio Chem 6:573-575, 2002.
272. Santoro, S.W., Schultz, P.G. “Directed evolution of the site specificity of Cre recombinase.” Proc. Natl. Acad. Sci. (USA), 99(7):4185-4190, 2002.
273. Gildersleeve, J., Janes, J., Ulrich, H., Yang, P., Barbars, G., Schultz, P.G. “Development of a Genetic Selection for Catalytic Antibodies.” Bioorg. Med. Chem. Lett., 12:1691-1694, 2002.
274. Perez, O.D., Chang, Y.T., Rosania, G, Sutherlin, D, Schultz, P.G. “Inhibition and Reversal of Myogenic Differentiation by Purine-Based Microtubule Assembly Inhibitors.” Chem. Biol. 9:475-483, 2002.
275. Chang, Y.T., Choi, J., Ding, S., Prieschl, E.E., Baumruker, T., Lee, J.M., Chung, S.K., Schultz, P.G. “The Synthesis and Biological Characterization of a Ceramide Library.” J. Am. Chem. Soc., 124(9):1856-1857, 2002.
276. Supekova, L., Pezacki, J.P., Su, A., Loweth, C., Reidl, R., Geierstanger, B., Massari, E., Murre, C., Schultz, P.G., Wemmer, D. “Genomic Effects of Polyamide/DNA Interactions on mRNA Expression.” Chem. & Biol., 9:821-827, 2002.
277. Chin, J.W., Martin, A.B., King, D.S., Wang, L., Schultz, P.G. “Addition of a Photocrosslinking Amino Acid to the Genetic Code of Escherichia coli.” Proc. Natl. Acad. Sci. (USA), 10:1073-1077, 2002.
278. Schultz, P.G., Lerner, R.A. “Completing the Circle.” Nature Concepts, 418:485, 2002.
279. Li, S., Liao, J., Cutler, G., Hoey, T., Hogenesch, J.B., Cooke, M.P., Schultz, P.G., Ling, X.B. “Comparative Analysis of Human Genome Assemblies Reveals Genome-Level Differences.” Genomics, 80(2):138-139, 2002.
280. Zhang, Z., Wang, L., Brock, A., Schultz, P.G. “The Selective Incorporation of Alkenes into Proteins in Escherichia coli.” Angew. Chem., 41(15):2840-2842, 2002.
281. Chang, Y.T., Choi, G., Bae, Y.S., Burdett, M., Moon H.S., Lee, J.W., Gray, N.S., Schultz, P.G., Meijer, L., Chung, S.K., Choi, K.Y., Suh, P.G., Ryu, S.H. “Purine-Based Inhibitors of Inositol-1,4,5-trisphosphate-3-kinase. ChemBioChem, 9:897-901, 2002.
282. Su, A., Guidotti, L.G., Pezacki, J.P., Chisari, F.V., Schultz, P.G. “Gene Expression During the Priming Phase of Liver Regeneration after Partial Hepatectomy in Mice.” Proc. Natl. Acad. Sci. (USA), 99(17):11181-11186, 2002.
283. Winssinger, N., Ficarro, S., Schultz, P.G., Harris, J.L. “Profiling protein function with small molecule microarrays.” Proc. Natl. Acad. Sci. (USA), 99(17)11139-11144, 2002.
284. Santoro, S.W., Wang, L., Herberich, B., King, D.S., Schultz, P.G. “An Efficient System for the Evolution of Aminoacyl-tRNA Synthetase Specificity.” Nature Biotechnology, 20:1044-1048, 2002.
285. Chin, J., Santoro, S.W., A.B., King, D.S., Wang, L., Schultz, P.G. “Addition of p-azido-L-phenylalanine to the Genetic Code of Escherichia coli.” J. Am. Chem. Soc., 124(31):9026-9027, 2002.
286. Yu, C., Henry, A.A., Schultz, P.G., Romesberg, F.E. “Polymerase Recognition of Unnatural Base Pairs.” Angew. Chem., 41(20):3841-3844, 2002.
287. Knockaert, M., Lenormand, P., Gray, N., Schultz, P.G., Pouyssegur, J., Meijer, L. “p42/p44 MAPs are intracellular targets of the CDK inhibitor purvalanol.” Oncogene, 21:6413-6424, 2002.
288. Su, A.I., Pezacki, J.P., Wodicka, L., Brideau, A.D., Supekova, L., Thimme, R., Wieland, S., Bukh, J., Purcell, R.H., Schultz, P.G., Chisari, F.V. “Genomic Analysis of the Host Response to Hepatitis C Virus Infection.” Proc. Natl. Acad. Sci. (USA), 99(24):15669-15674,2002.
289. Chin, J.W., Schultz, P.G. “In vivo Photocrosslinking with Unnatural Amino Acid Mutagenesis.” ChemBioChem, 11:1135-1137, 2002.
290. Wu, X., Ding, S., Ding, Q., Gray, N.S., Schultz, P.G. “A Small Molecule with Osteogenesis-Inducing Activity in Multipotent Mesenchymal Progenitor Cells.” J. Amer. Chem. Soc., 124(49):14520-14521, 2002.
291. Wu, T.Y.H., Schultz, P.G. “A Versatile Linkage Strategy for Solid-Phase Synthesis of N,N-Dimethyltryptamines and Beta-Carbolines.” Organic Letters, 4(23):4033-4036, 2002.
292. Zimmermann, N., Meggers, E., Schultz, P.G. “A Novel Silver (I)-Mediated DNA Base Pair.” J. Amer. Chem. Soc., 124(46); 13684-13685, 2002.
293. Lesley, S., Kuhn, P., Godzik, A., Schultz, P.G., Wilson, I.A., Stevens, R. “Structural genomics of the Thermotoga maritime proteome implemented in a high-throughput structure determination pipeline.” Proc. Natl. Acad. Sci. (USA), 99(18):11664-11669, 2002.
294. Schultz, P.G., Yin, J., Lerner, R.A. “The Chemistry of the Antibody Molecule.” Angewandte Chemie, 41(23):4427-4437, 2002.
295. Chapman, E., Ding, S., Schultz, P.G., Wong, C. “A Potent and Highly Selective Sulfontransferase Inhibitor.” J. Amer. Chem. Soc., 124(49):14524-14525, 2002.
296. Wang, L., Zhang, Z., Brock, A., Schultz, P.G. “Addition of the Keto Functional Group to the Genetic Code of Escherichia coli.” Proc. Natl. Acad. Sci. (USA), 100(1):56-61,2003.
297. Lin, Q., Barbas, C.F., Schultz, P.G. “Small-Molecule Switches for Zinc Finger Transcription.” J. Amer. Chem. Soc., 125(3):612-613, 2003.
298. Mehl, R., Anderson, J.C., Santoro, S., Wang, L., Martin, A., King, D.S., Horn, D.M., Schultz, P.G. “Generation of a Bacterium with a 21 Amino Acid Genetic Code.” J. Am. Chem. Soc., 125:935-939,2003.
299. Wang, L., Xie, J., Deniz, A.A., Schultz, P.G. “Unnatural Amino Acid Mutagenesis of Green Fluorescent Protein.” J. Org. Chem., 68(1):174-176, 2003.
300. Wieland, S.F., Vega, R.G., Muller, R., Evans, C., Hilbush, B., Guidotti, L.G., Sutcliffe, J.G., Schultz, P.G., Chisari, F.V. “Searching for Interferon-Induced Genes that Inhibit Hepatitis B Virus Replication in Transgenic Mouse Hepatocytes.” J. Virol., 77(2):1227-1236, 2003.
301. Santoro, S.W., Schultz, P.G. “Directed Evolution of the Substrate Specificities of a Site-Specific Recombinase and an Aminoacyl-tRNA Synthetase Using Fluorescence Activated Cell Sorting.” in Methods in Molecular Biology, Directed Enzyme Evolution: Screening and Selections Methods, (eds., F. H. Arnold and G. Georgiou ) Humana Press Inc., Totowa, NJ, vol. 230, pp, 291-312, 2003.
302. Licht, S.S., Sonnleitner, A., Weiss, S., Schultz, P.G. “A Rugged Energy Landscape Mechanism for Trapping of Transmembrane Receptors During Endocytosis.” Biochemistry, 42(10):2916-2925,2003.
303. Liu, H., Wang, L., Brock, A., Wong, C-H., Schultz, P.G. “A Method for the Generation of Glycoprotein Mimetics.” J. Amer. Chem. Soc., 125(7):1702-1703, 2003.
304. Salomon, A.R., Ficarro, S.B., Brill, L.M., Brinker, A., Phung, Q.T., Ericson, C., Sauer, K., Brock, A., Horn, D.M., Schultz, P.G., Peters, E.C. “Profiling of Tyrosine Phosphorylation Pathways in Human Cells Using Mass Spectrometry.” Proc. Natl. Acad. Sci. (USA), 100(2):443-448,2003.
305. Yin, J., Andryski, S., Beuscher, A., Stevens, R.C., Schultz, P.G. “Structural Evidence for Substrate Strain in Antibody Catalysis.” Proc. Natl. Acad. Sci. (USA), 100(3)856:861,2003.
306. Zhang, Z., Smith, B., Wang, L., Brock, A., Cho, C., Schultz, P.G. “A New Strategy for the Site-Specific Modification of Proteins in vivo.” Biochem. 42(22):6735-6746, 2003.
307. Magliery, T.J., Pastrnak, M., Anderson, J.C., Santoro, S.W., Herberich, B., Meggers, E., Wang, L., Schultz, P.G. “In vitro Tools and in vivo Engineering: Incorporation of Unnatural Amino Acids into Proteins” in Translation Mechanisms; Lapointe, Jacques; Brakier-Gingras, Léa, Eds,; Landes Bioscience/Eurekah.com: Georgetown, TX and Kluwer Academic/Plenum: New York, NY, 2003; pp. 95-114.
308. Ding, S., Wu, T.Y.H., Brinker, A., Peters, E.C., Hur, W., Gray, N.S., Schultz, P.G. “Synthetic Small Molecules that Control Stem Cell Fate.” Proc. Natl. Acad. Sci. (USA), 100(13):7632-7637, 2003.
309. Yin, J., Beuscher, A., Andryski, S., Stevens, R.C., Schultz, P.G. “Structural Plasticity and the Evolution of Antibody Affinity and Specificity.” J. Mol. Biol., 330:651-656, 2003.
310. Matsuda, S., Henry, A.A., Schultz, P.G., Romesberg, F.E. “The Effect of Minor Groove Hydrogen-Bond Acceptors and Donors on the Stability and Replication of Four Unnatural Base Pairs.” J. Amer. Chem. Soc., 125(20); 6134-6139., 2003.
311. Chin, J.W., Cropp, T.A., Chu, S., Meggers, E., Schultz, P.G. “Progress Toward an Expanded Eukaryotic Genetic Code.” Chem. Biol., 10:511–519, 2003.
312. Chin, J.W., Cropp, T.A., Anderson, J.C., Mukherji, M., Zhang, Z., Schultz, P.G. “An Expanded Eukaryotic Genetic Code.” Science, 301:964-967, 2003.
313. Liao, J., Schultz, P.G. “Three Sweet Receptor Genes Are Clustered in Human Chromosome 1.” Mamm. Genome, 14(5):291-301, 2003.
314. Anderson, J.C., Schultz, P.G. “Adaptation of an Orthogonal Archaeal Leucyl-tRNA and Synthetase Pair for Four-base, Amber, and Opal Suppression.” Biochem,42(32); 9598-9608, 2003.
315. Deiters, A., Cropp, T.A., Mukherji, M., Chin, J.W., Anderson, C., Schultz, P.G. “Adding Amino Acids with Novel Reactivity to the Genetic Code of Saccharomyces Cerevisiae.” J. Amer. Chem. Soc., 125(39):11782 – 11783, 2003.
316. Santoro, S., Anderson, J.C., Lakshman, V., Schultz, P.G. “An Archaebacteria-derived Glutamyl- tRNA Synthetase and tRNA Pair for Unnatural Amino Acid Mutagenesis of Proteins in Escherichia Coli.” Nuc. Acids Res., 31(23):6700-6709, 2003.
317. Chanda, S. K., White, S., Orth, A., Reisdorph, R., Miraglia, L., Thomas, R., DeJesus, P., Mason, D. E., Huang, Q., Vega, R., Yu, D., Nelson, C., Smith, B. M., Terry, R., Linford, A.S., Yu, Y., Chirn, G., Song, C., Labow, M.A., Cohen, D., King, F., Peters, E., Schultz, P.G., Vogt, P.K., Hogenesch, J., and Caldwell, J.S. “Genome-scale Functional Profiling of the Mammalian AP-1 Signaling Pathway.” Proc. Natl. Acad. Sci. (USA), 100(21):12153-12158, 2003.
318. Baldwin, E.P., Martin, S.S., Abel, J., Gelato, K.A., Kim, H., Schultz, P.G., Santoro, S.W. “A Specificity Switch in Selected Cre Recombinase Variants is Mediated by Macromolecular Plasticity and Water.” Chem & Biol., 10(11):1085-1094, 2003.
319. Alfonta, L, Zhang, Z., Uryu, S., Loo, J.A., Schultz, P.G. “Site-Specific Incorporation of a Redox Active Amino Acid into Proteins.” J. Am. Chem. Soc., 125:14662-14663, 2003.
320. Gildersleeve, J., Varvak, A., Atwell, S., Evans, D. Schultz, P.G. “Development of a High-Throughput Screen for Protein Catalysts: Application to the Directed Evolution of Antibody Aldolases.” Angew. Chem., 42(48):5971-5973, 2003.
321. Wu, T.Y.H., Hassig, C., Wu, Y., Ding, S., Schultz, P.G. “Design, Synthesis, and Activity of HDAC Inhibitors with an N-formyl Hydroxylamine Head Group.” Bio. Med. Chem. Letters, 14(2):449-453, 2003.
322. Mirotsou, M., Watanabe, C., Schultz, P.G., Pratt, R.E., Dzau, V.J. “Elucidating the Molecular Mechanism of Cardiac Remodeling Using a Comparative Genomic Approach.” Physio. Genomics, 15: 115-126, 2003.
323. Zimmermann, N., Meggers, E., Schultz, P.G. “A Second-Generation Copper (II)-Mediated Metallo-DNA-Base Pair.” Bioorg. Chem., 32(1):13-25, 2004.
324. Zhang, Z., Gildersleeve, J., Yang Y.Y., Xu, R., Loo, J.A., Uryu, S., Wong, C.H., Schultz, P.G. “A New Strategy for the Synthesis of Glycoproteins.” Science, 303(16):371- 373, 2004.
325. Esaki, M., Kanamori, T., Nishikawa, S., Shin, I., Schultz, P.G., Endo, T. “Tom40 Protein Import Channel Binds to Non-Native Proteins and Prevents their Aggregation” Nature Struct. Biol., 10(12):998-994, 2003.
326. Li, S., Cutler, G., Liu, J.J., Hoey, T., Chen, L., Schultz, P.G., Liao, J., Ling, X.B. “A comparative analysis of HGSC and Celera human genome assemblies and gene sets.” Bioinformatics, 19(13):1597-1605, 2003.
327. Chen, S., Zhang, Q, Wu, X., Schultz, P.G., Ding, S. “Dedifferentiation of Lineage-Committed Cells by a Small Molecule.” J. Amer. Chem. Soc., 126(2):410-411, 2004.
328. Wu, X., Ding, S., Ding, Q., Gray, N.S., Schultz, P.G. “Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells.” J. Amer. Chem. Soc., 126:1590-1591, 2004.
329. Yin, J., Mills, J.H., Schultz, P.G. “A Catalysis-based Selection for Peroxidase Antibodies with Increased Activity.” J. Amer. Chem. Soc.,126(10):3006-7, 2004.
330. Huang, Q, Raya, A., Dejesus, P., Chao, S.H., Quon, K.C., Caldwell, J.S., Chanda, S.K., Izpisua-Belmonte, J.C., Schultz, P.G. “Identification of p53 Regulators by Genome-wide Functional Analysis.” Proc. Natl. Acad. Sci. (USA), 101(10):3456-3461,2004.
331. Williams, B., Watanabe, C.M.H., Schultz, P.G., Rimbach, G., Krucker, T. “Age-related effects of Ginko biloba extract on synaptic plasticity and excitability.” Neurobiology of Aging, 25 (7): 955-962,2004.
332. Wignall, S.M., Gray, N.S., Chang, Y.T. Juarez, L., Jacob, R., Burlingame, A., Schultz, P.G., Heald, R. “Identification of a novel protein regulating microtubule stability through a chemical approach.” Chem. & Biol.,11(1):135-46, 2004.
333. Torres, F.E., Kuhn, P., De Bruyker, D., Bell, A.G., Wolkin, M.V., Peeters, E., Williamson, J.R., Anderson, G.B., Schmitz, G.P., Recht, M.I., Schweizer, S., Scott, L.G., Ho, J.H., Elrod, S.A., Schultz, P.G., Lerner, R.A., Bruce, R.H. “Enthalpy Arrays.” Proc. Natl. Acad. Sci. USA, 101(26):9517-9622, 2004.
334. Ding, S., Schultz, P.G. “A Role for Chemistry in Stem Cell Biology.” Nature Biotech. 22(7):833-840, 2004.
335. Zhang, Z., Alfonta, L., Tian, F., Bursulaya, B., Uryu, S., King, D.S., Schultz, P.G. “Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells.” Proc. Natl. Acad. Sci.(USA), 101(24):8882-8887,2004.
336. Zheng, L., Liu, J., Batalov, S., Zhou, D., Orth, A., Ding, S., Schultz, P.G. “An Approach to Genomewide Screens of Expressed Small Interfering RNAs in Mammalian Cells.” Proc. Natl. Acad. Sci. (USA), 101(1): 135-140, 2004.
337. Anderson, J.C., Wu, N., Santoro, S.W., Lakshman, V., King, D.S., Schultz, P.G. “An Expanded Genetic Code with a Functional Quadruplet Codon.” Proc. Natl. Acad. Sci. (USA), 101(20): 7566-7571,2004.
338. Wu, T., Wagner, K.W., Bursulaya, B., Schultz, P.G., Deveraux, Q.L. “Development and Characterization of Non-Peptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interactions.” Chem & Biol., 10(8):759-67, 2004.
339. Wu, X., Walker, J., Zhang, J., Ding, S., Schultz, P.G. “Purmorphamine Induces Osteogenesis by Activation of the Hedgehog Signaling Pathway.” Chem. & Bio., 11(9):1229-38, 2004.
340. Xie, J., Wang, L., Wu, N., Brock, A., Spraggon, G., Schultz, P.G. “The Site-specific Incorporation of p-Iodo-L-phenylalanine into Proteins for Structure Determination.” Nature Biotech. 22(10):1297-301, 2004.
341. Cropp, T.A., Schultz, P.G. “An Expanding Genetic Code.” Trends in Genetics, 20(12): 625-630, 2004.
342. Schlieker, C., Weibezahn, J., Patzelt, H., Tessarz, P., Strub, C., Zeth, K., Erbse, A., Schneider-Mergener, J., Chin, J.W., Schultz, P.G., Bukau, B., Mogk, A. “Substrate Recognition by the AAA+ Chaperone ClpB.” Nat. Struct. Mol. Biol., 11(7):607-15, 2004.
343. Wu, N., Deiters, A., Cropp, T.A., Schultz, P.G. “A Genetically Encoded Photocaged Amino Acid.” J. Am. Chem. Soc., 126 (44):14306-7, 2004.
344. Matsuda, S., Schultz, P.G., Romesberg, F.E. “Optimization of Interstrand Hydrophobic Packing Interactions Within Duplex DNA.” J. Am. Chem. Soc., 126(44):14419-27, 2004.
345. Wang, L, Schultz, P.G. “Expanding the Genetic Code.” Angew. Chem., 44(1):34-66, 2004.
346. Tian, F., Tsao, M.L., Schultz, P.G. “A Phage Display System, With Unnatural Amino Acids.” J. Am. Chem. Soc., 126(49):15962-3, 2004.
347. Deiters, A., Cropp, T.A., Summerer, D., Mukherji, M., Schultz, P.G. “Site-Specific PEGylation of Proteins Containing Unnatural Amino Acids.” Bioorg. & Med. Chem. Lett., 14(23):5743-5, 2004.
348. Venkateshrao, S., Yin, J., Jarzecki, A., Schultz, P.G., Spiro, T.G. “Porphyrin Distortion During Affinity-Maturation of a Ferrochelatase Antibody, Monitored by Resonance Raman Spectroscopy.” J. Amer. Chem. Soc., 126(50):16361-7, 2004.
349. Xu, R., Hanson, S.R., Zhang, Z., Yang, Y., Schultz, P.G., Wong, C. “Site-Specific Incorporation of the Mucin-type N-Acetylgalactosamine-α-O-Threonine into Protein in Escherichia coli.” J. Am. Chem. Soc., 126(48):15654-5, 2004.
350. Deiters, A., Geierstanger, B.H., Schultz, P.G. “Site-Specific In Vivo Labeling of Proteins for NMR Studies.” ChemBioChem, 6(1):55-8, 2005.
351. Luesch, H., Wu, T.Y.H., Ren, P., Gray, N.S., Schultz, P.G., Supek, F. “A Genome-Wide Overexpression Screen in Yeast for Small Molecule Target Identification.” Chem. & Biol., 12(1):55-63,2005.
352. Liu, J., Bang, A., Kintner, C., Orth, T., Chanda, S., Ding, S., Schultz, P.G. “Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genomewide functional analysis.” Proc. Natl. Acad. Sci., 102(6):1927-32, 2005.
353. Liu, J., Wu, X., Mitchell, B., Kintner, C., Ding, S., Schultz, P.G. “A Small-Molecule Agonist of the Wnt Signaling Pathway.” Angew. Chem., 44(13):1987-1990, 2005.
354. Deiters, A., Schultz, P.G. “In Vivo Incorporation of an Alkyne into Proteins in Escherichia coli.” Bioorg. Med. Chem. Lett., 15(5):1521-4, 2005.
355. Ding, S., Schultz, P.G. “Small molecules and Future Regenerative Medicine.” Current Topics in Medicinal Chemistry, 5(4): 383-394, 2005.
356. Zhang, Y., Wang, L., Schultz, P.G., Wilson, I.A. “Crystal Structures of apo Wild-Type M. jannaschii TyrRS and a Mutant Synthetase Specific for O-Methyl-L-Tyrosine.” Protein Science, 14(5):1340-9, 2005.
357. Xie, J., Schultz, P.G. “An Expanding Genetic Code.” Methods, 36(3):227-38, 2005.
358. Willingham, A.T., Orth, A.P., Batalov, S., Peters, E.C., Wen, B.G., Aza-Blanc, P., Hogenesch, J.B., Schultz, P.G. “A Strategy for Determining the Function of Noncoding RNAs Identifies a Repressor of NFAT.” Science, 309(5740): 1570-3, 2005.
359. Turner, J.M., Graziano, J., Spraggon, G., Schultz, P.G. “Structural Characterization of a p-Acetylphenylalanyl Aminoacyl-tRNA Synthetase.” J. Am. Chem. Soc., 127(43): 14976-14977,2005.
360. Xie, J., Schultz, P.G. “Adding Amino Acids to the Genetic Repertoire.” Curr. Opin Chem Biol., 9:548-554,2005.
361. Tsao, M., Tian, F., Schultz, P.G. “Selective Staudinger Modification of Proteins Containing p-Azidophenylalanine.” ChemBioChem. 6(12): 2147-2149, 2005.
362. Warashina, M., Min, K.H., Kuwabara, T., Huynh, A., Gage, F.H., Schultz, P.G., Ding, S. “A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells.” Angew. Chem., 45(4):591-593, 2005.
363. Bose, M., Groff, D., Xie, J., Brustad, E., Schultz, P.G. “The Incorporation of a Photoisomerizable Amino Acid into Proteins in E. coli.” J. Am. Chem. Soc., 128(2):388-9, 2005.
364. Sagan, S.M., Rouleau, Y., Leggiadro, C., Supekova, L., Schultz, P.G., Su, A.I., Pezacki, J.P. “The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.” Biochem. Cell Biol., 84:67-79, 2006.
365. Luesch, H., Chanda, S.K., Raya, R. M., Orth, A.P., Walker, J.R., Izpisúa Belmonte, J.C., Schultz, P.G. “A Functional Genomics Approach to the Mode of Action of the Antiproliferative Natural Product Apratoxin A.” Nature Chem Bio., 2(3):158-167, 2006.
366. Melnick, J.S., Janes, J., Kim, S., Chang, J.Y., Sipes, D.G., Gunderson, A., Jarnes, L., Matzen, J.T., Garcia, M.E., Hood, T.L., Beigi, R., Xia, G., Harig, R.A., Asatryan, H., Yan, S.F., Zhou, Y., Gu, X-J., Saadat, A., Zhou, V., King, F.J., Shaw, C.M., Su, A.I., Downs, R., Gray, N.S., Schultz, P.G., Warmuth, M., Caldwell, J.S. “An Efficient, Rapid System for Profiling the Cellular Activities of Molecular Libraries.” Proc. Natl. Acad. Sci., 103(9):3153–3158, 2006.
367. Ryu, Y., Schultz, P.G. “Efficient incorporation of unnatural amino acids into proteins in Escherichia coli.” Nature Methods, 3(4):263-5, 2006.
368. Deiters, A., Groff, D., Ryu, Y., Xie, J., Schultz, P.G. “A Genetically Encoded Photocaged Tyrosine.” Angew. Chemie, 45(17):2728-2731, 2006.
369. Turner, J.M., Graziano, J., Spraggon, G., Schultz, P.G. “Structural plasticity of an aminoacyl-tRNA synthetase active site.” Proc. Natl. Acad. Sci., 103(17):6483-8, 2006.
370. Berezhna, S.Y., Supekova, L., Supek, F., Schultz, P.G., Deniz, A.A. “siRNA in human cells selectively localizes to target RNA sites.” Proc. Natl. Acad. Sci., 103(20):7682–7687, 2006.
371. Tsao, M.L., Summerer, D., Ryu, Y., Schultz, P.G. “The genetic incorporation of a distance probe into proteins in Escherichia coli.” J Am Chem Soc., 128(14):4572-3, 2006.
372. Summerer, D., Chen, S., Wu, N., Deiters, A., Chin, J., Schultz, P.G. “A Genetically Encoded, Fluorescent Amino Acid.” Proc. Natl. Acad. Sci. (USA), 103(26):9785–9789, 2006.
373. Cho, C.Y., Koo, S-H., Wang, Y., Callaway, S., Hedrick, S., Mak, P.A., Orth, A.P., Peters, E.C., Saez, E., Montminy, M., Schultz, P.G., Chanda, S.K., “Identification of the Tyrosine Phosphatase PTP-MEG2 as an Antagonist of Hepatic Insulin Signaling.” Cell Metab., 3(5):367-78, 2006.
374. Wang, L., Xie, J., Schultz, P.G. “Expanding the Genetic Code.” Ann. Rev. Biophys. Biomol. Struct., 9(35):225-249, 2006.
375. Wang, J., Xie, J., Schultz, P.G. “A Genetically Encoded Fluorescent Amino Acid.” J. Am. Chem. Soc., 128(27):8738-9, 2006.
376. Hampton, G.M. “A genetic siRNA screen for modulators of tumor cell motility identifies MAP4K4 as a pro-migratory kinase.” Proc. Natl. Acad. Sci., 103(10):3775-80, 2006.
377. Zeng, H., Xie, J., Schultz, P.G. “Genetic introduction of a diketone-containing amino acid into proteins.” Bioorg Med Chem Lett., 16: 5356–5359, 2006.
378. Xie, J., Schultz, P.G. “A chemical toolkit for proteins – an expanded genetic code.” Nat. Rev. Mol. Cell Biol., 7(10):775-82, 2006.
379. Schultz, K.C., Supekova, L., Ryu, Y., Xie, J., Perera, R., Schultz, P.G. “A Genetically Encoded Infrared Probe of Protein Structure.” J. Am. Chem. Soc., 128(43):13984-5, 2006.
380. Mukherji, M., Cho, C., Supekova, L., Wang, Y., Batalov, S., Bell, R., Martin, C., Sahasrabuhde, S., Orth, A.P., Chanda, S.K., Schultz, P.G., “Functional Analysis of Human Genome for Cell Cycle Regulators.” Proc. Natl. Acad. Sci. (USA), 103 (40): 14819-14824, 2006.
381. Chen, S., Do, J., Zhang, Q., Yao, S., Yan, F., Peters, E., Scholer, H., Schultz, P.G., Ding, S. “Self-renewal of Embryonic Stem Cells by a Small Molecule.” Proc. Natl. Acad. Sci., 103(46):17266-17271, 2006.
382. Liu, C., Schultz, P.G. “Recombinant expression of selectively sulfated proteins in E. coli.” Nat. Biotechnol., 24(11):1436-40, 2006.
383. Tian, F., Debler, E.W., Millar, D.P., Deniz, A.A., Wilson, I.A., Schultz, P.G. “Multilcolor Fluorescent Antibodies.” Angew. Chem., 45(46):7763-7765, 2006.
384. Saraf-Levy, T., Santoro, S.W., Volpin, H., Kushnirsky, T., Eyal, Y., Schultz, P.G., Gidoni, D., Carmi, N. “Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex.” Bioorg. Med. Chem., 14(9):3081-9, 2006.
P1. Liu, D., Schultz, P.G. “Generating New Molecular Function: A Lesson from Nature.” Essays in Contemporary Chemistry: From Molecular Structure Towards Biology, (Quinkert, G., Kisakürek, M.V., eds.),Wiley-VCH, pp.341-380 2001.
P2. Mukherji, M., Brill, L.M., Ficarro, S.B., Hampton, G.M., Schultz, P.G. “A Phosphoproteomic Analysis of the ErbB2 Receptor Tyrosine Kinase Signaling Pathways.” Biochemistry, in press, 2006.
P3. Macpherson, L.J., Dubin, A.E., Evans, M.J., Marr, F., Schultz, P.G., Cravatt, B.F., Patapoutian, A. “Noxious compounds activate TRPA1 ion channel via covalent modification of cysteines.” Nature, In press, 2006.
P4. Galkin, A., Melnick, J., Kim, S., Hood, T., Li, N., Li, L., Xia, G., Steensma, R., Chopiuk, G., Jiang, J., Wan, Y., Ding, P. Zun, F., Schultz, P.G., Gray, N.S., Warmuth, M. “Identification of NVP-TAE684: A potent, selective and efficacious inhibitor of NPM-ALK.” Proc. Natl. Acad. Sci. (USA), in press, 2006.
P5. Hong, J., Lee, J., Min, K-H., Walker, J.R., Gray, N.S., Cho, C.Y., Schultz, P.G. “Identification and characterization of small molecule inducers of epidermal keratinocyte differentiation.” ACS Chemical Biology, in press, 2006.
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